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Journal of Endocrinology, ISSN 0022-0795, 2014, Volume 223, Issue 1, pp. T71 - T81
Journal Article
Science Translational Medicine, ISSN 1946-6234, 07/2014, Volume 6, Issue 247
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 02/2019
NGM282, an engineered FGF19 analogue, rapidly and significantly reduced liver fat content in a multi-center, randomized, double-blind, placebo-controlled study... 
Journal Article
The Journal of endocrinology, 10/2014, Volume 223, Issue 1, p. T71
The molecular mechanisms of body weight and body composition regulation have long been a research focus in the hopes of identifying tractable pathways for... 
Hypoglycemic Agents - therapeutic use | Animals | Obesity - drug therapy | Humans | Leptin - therapeutic use | Treatment Outcome | Islet Amyloid Polypeptide - therapeutic use | Lipodystrophy - drug therapy | Diabetes Mellitus, Type 2 - drug therapy | Non-alcoholic Fatty Liver Disease - drug therapy
Journal Article
American Journal of Clinical Nutrition, ISSN 0002-9165, 01/2010, Volume 91, Issue 1, pp. 267S - 272S
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a clinically validated target for treatment of insulin resistance. PPAR gamma activation by... 
METFORMIN | THIAZOLIDINEDIONE | NUTRITION & DIETETICS | LIGAND | CLINICAL-TRIAL | COMBINATION
Journal Article
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 07/2014, Volume 6, Issue 247, pp. 247ra100 - 247ra100
Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | HORMONE | INTRAHEPATIC CHOLESTASIS | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | MICE | EXPRESSION | CANCER | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Fibroblast Growth Factors - adverse effects | Liver - pathology | Humans | Middle Aged | Fibroblast Growth Factors - genetics | Male | Cholagogues and Choleretics - adverse effects | Cholestenones - blood | Fibroblast Growth Factors - biosynthesis | Cholestasis, Intrahepatic - drug therapy | Healthy Volunteers | RNA, Messenger - metabolism | Cholagogues and Choleretics - therapeutic use | Genetic Variation | Young Adult | Liver - drug effects | Adult | Liver Neoplasms - pathology | Cholestasis, Extrahepatic - pathology | Disease Models, Animal | Fibroblast Growth Factors - therapeutic use | Gene Transfer Techniques | Cholestasis, Intrahepatic - genetics | Double-Blind Method | Liver Neoplasms - genetics | Risk Assessment | Cholestasis, Intrahepatic - pathology | Down-Regulation | Liver - metabolism | Bile Acids and Salts - metabolism | Biomarkers - blood | Cholestasis, Extrahepatic - genetics | Gene Expression Regulation, Enzymologic | Cholagogues and Choleretics - pharmacokinetics | Cholesterol 7-alpha-Hydroxylase - genetics | Cholestasis, Intrahepatic - metabolism | Animals | Fibroblast Growth Factors - pharmacokinetics | Cholesterol 7-alpha-Hydroxylase - metabolism | Liver Neoplasms - metabolism | Mice | Cholestasis, Extrahepatic - metabolism | Australia | Cholestasis, Extrahepatic - drug therapy
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 06/2018, Volume 67, Issue 6, pp. 2150 - 2166
Journal Article
Journal of hepatology, 12/2018
NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with nonalcoholic steatohepatitis... 
Journal Article
The American Journal of Clinical Nutrition, ISSN 0002-9165, 01/2010, Volume 91, Issue 1, p. 267S
  Peroxisome proliferator-activated receptor ... (PPAR...) is a clinically validated target for treatment of insulin resistance. PPAR... activation by full... 
Toxicity | Genes | Glucose | Diabetes | Effects | Insulin | Cells
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2017, Volume 66, Issue 6, pp. 1182 - 1192
Journal Article