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Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2020, Volume 68, Issue 1, pp. 58 - 63
Polycomb repressive complex 2 (PRC2) is an attractive drug target for anti-cancer treatment. Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2... 
CANCER-CELLS | EZH2-EED INTERACTION | METHYLATION | CHEMISTRY, MEDICINAL | virtual screening | molecular dynamics simulation | METHYLTRANSFERASE ACTIVITY | polycomb repressive complex 2 | GLIDE | H3K27 | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | SELECTIVE INHIBITOR | ACCURATE DOCKING | EZH2-EED interaction inhibitor | LYMPHOMA | PHARMACOLOGY & PHARMACY | Binding, Competitive | Polycomb Repressive Complex 2 - antagonists & inhibitors | Small Molecule Libraries - pharmacology | Catalytic Domain | Polycomb Repressive Complex 2 - genetics | Protein Interaction Domains and Motifs - drug effects | Humans | Recombinant Proteins - chemistry | Small Molecule Libraries - metabolism | Recombinant Proteins - biosynthesis | Protein Subunits - metabolism | Recombinant Proteins - isolation & purification | Small Molecule Libraries - chemistry | Drug Design | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Subunits - antagonists & inhibitors | Polycomb Repressive Complex 2 - metabolism | Binding Sites | Protein Subunits - genetics | Binding | Evaluation | Inhibitor drugs | Computer simulation | Molecular dynamics | Lymphoma | Molecular docking | Proteins | Polycomb group proteins | Inhibitors | Lymphocytes B | Lysine | Computer applications | Biological computing | Surface area | Histone H3 | B-cell lymphoma
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, p. 317
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a... 
Epigenetic inheritance | Arginine | Methyltransferases | Leukemia | Resveratrol | Lymphomas | Drug discovery
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 6, pp. 1090 - 1100
OBJECTIVE—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an initial event responsible for monocyte recruitment in atherogenesis.... 
atherosclerosis | hyperlipidemia | endothelial cell | mitochondria | reactive oxygen species | PROGENITOR CELLS | VARESPLADIB | PHOSPHOLIPASE A INHIBITOR | CARDIOVASCULAR EVENTS | RANDOMIZED CLINICAL-TRIAL | ACUTE CORONARY SYNDROME | HEART-DISEASE | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | MICE | ATHEROSCLEROTIC PLAQUE | HEMATOLOGY | Hyperlipidemias - genetics | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Transcription Factor AP-1 - genetics | Atherosclerosis - genetics | Humans | Aorta - metabolism | Transcription Factor AP-1 - metabolism | Aortic Diseases - metabolism | Time Factors | Membrane Potential, Mitochondrial | Calcium Signaling | Aortic Diseases - pathology | Disease Models, Animal | Atherosclerosis - pathology | Genetic Predisposition to Disease | Lysophosphatidylcholines - pharmacology | Hyperlipidemias - metabolism | Oxidation-Reduction | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Lysophosphatidylcholines - metabolism | Gene Expression Profiling - methods | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Metabolomics - methods | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Intercellular Adhesion Molecule-1 - metabolism | Phenotype | Animals | Apolipoproteins E - genetics | Intercellular Adhesion Molecule-1 - genetics | Oxidative Stress - drug effects | Endothelial Cells - drug effects | vascular inflammation
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 317 - 333
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a... 
PRMT5 inhibitors | N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives | Anti-tumor | SM PROTEINS | PRMT5 | METHYLATION | COMPLEX | CHEMISTRY, MEDICINAL | PICLN | GROWTH | IDENTIFICATION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2018, Volume 157, pp. 867 - 876
The histone acetyltransferases (HATs) in mammals include GCN5 N-acetyltransferases, the MOZ, YBF2, SAS2, and TIP60 proteins, and the orphan HATs. The males... 
High throughput screening | Epigenetics | Inhibitor | MOF | Histone acetyltransferase | GCN5 | DESIGN | CHEMISTRY, MEDICINAL | PROTEIN | ACETYLATION | GLOBAL GENE-EXPRESSION | LUNG-CANCER | REPRESSES | BIOLOGICAL EVALUATION | CHROMATIN TRANSCRIPTION | Histones | Epigenetic inheritance | International trade | Gene expression | Lysine
Journal Article
Journal Article
European journal of medicinal chemistry, 12/2018, Volume 164, p. 317
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a... 
Journal Article
Neural Computing and Applications, ISSN 0941-0643, 1/2014, Volume 24, Issue 1, pp. 13 - 20
Journal Article
中国科学通报:英文版, ISSN 1001-6538, 2012, Volume 57, Issue 25, pp. 3342 - 3352
cDNA library of Myrmecia incisa H4301 was constructed using 2 phage vectors. The library consisted of 1.5x106 clones with a recombination rate of 90%, and 1942... 
密码子使用 | 微藻 | 表达序列标签 | 脂肪酸合成 | 分类地位 | 生物合成途径 | 栗属 | cDNA文库
Journal Article
06/2016
The utility model discloses a test equipment of servo driver digital interface circuit. Wherein, this equipment includes: the communication circuit, the data... 
TESTING | MEASURING ELECTRIC VARIABLES | MEASURING MAGNETIC VARIABLES | MEASURING | PHYSICS
Patent
04/2016
The invention discloses a testing method and testing equipment of a digital interface circuit of a servo drive. The method comprises the steps that a level of... 
TESTING | MEASURING ELECTRIC VARIABLES | MEASURING MAGNETIC VARIABLES | MEASURING | PHYSICS
Patent
2008 2nd International Conference on Bioinformatics and Biomedical Engineering, ISSN 2151-7614, 05/2008, pp. 3401 - 3403
MT Transgenic Synechococcus sp . PCC7002 was used to adsorb the Zn 2+ in industry waste water, according to the high affinity of metallothionein (MT) to heavy... 
Fungi | Protein engineering | Costs | Microorganisms | Absorption | Density measurement | Amino acids | Water pollution | Pollution measurement | Wastewater treatment | Electroplate wastewater | Treatment of wastewater | Zn | absorption | Metallothionein | Synechococcus sp
Conference Proceeding
2008 2nd International Conference on Bioinformatics and Biomedical Engineering, ISSN 2151-7614, 05/2008, pp. 3398 - 3400
Transgenic cyanobacterium, Synechococcus sp., was used to absorb the heavy mental ions from industry waste water, according by the high affinity of... 
Fungi | Microorganisms | Absorption | Algae | Inorganic materials | Cells (biology) | Water pollution | Wastewater treatment | Sun | Biological materials
Conference Proceeding
IEEE International Conference on Bioinformatics and Biomedical Engineering. Proceedings, 01/2008, Volume 2, pp. 3398 - 3400
Transgenic cyanobacterium, Synechococcus sp., was used to absorb the heavy mental ions from industry waste water, according by the high affinity of... 
Journal Article
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