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Surgery for Obesity and Related Diseases, ISSN 1550-7289, 08/2019, Volume 15, Issue 8, pp. 1299 - 1310
Several anatomic and physiologic changes occur after Roux-en-Y gastric bypass (RYGB) and its associated weight loss. At present, no single unified model can... 
Drug metabolism | Roux-en-Y gastric bypass | Pharmacokinetics | CYP450 | Phenotypic exploration | SURGERY | TRANSPORTERS | QUANTIFICATION | CYP3A4 | P-GLYCOPROTEIN | CYTOCHROME-P450 ENZYMES | DRUG DISPOSITION | BARIATRIC SURGERY | METABOLIZING-ENZYMES | EXPRESSION | Health aspects | Analysis | Liver | Gastric bypass | Cytochrome P-450
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2017, Volume 39, Issue 8, pp. e71 - e71
Currently phenotypes of carriers of two fully-functional alleles (genetic activity score 2, gAS2) and carriers of one fully-functional and one non-functional... 
Internal Medicine | Medical Education | Drug interactions | Cytochrome P-450 | Current carriers | Gas1 protein | Gems | Cytochrome P450 | CYP2D6 protein | Alleles
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2017, Volume 39, Issue 8, pp. e18 - e19
New insights into the contribution of defined subtypes of GABAA receptors (GABAA Rs) to the different clinical effects of benzodiazepine (BDZ)s, including... 
Internal Medicine | Medical Education | GABA | Care and treatment | Pain | Anesthesia | Neuropathy | γ-Aminobutyric acid A receptors | Modulation
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 919 - 930
Background and purpose:  The major drug-metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the... 
CYP3A | drug-drug interactions | CYP2D6 | pharmacodynamics | oxycodone | oxymorphone | experimental pain | genetic polymorphism | drug–drug interactions | Pharmacodynamics | Oxycodone | Genetic polymorphism | Experimental pain | Drug-drug interactions | Oxymorphone | MORPHINE | CONTROLLED-RELEASE OXYCODONE | P-GLYCOPROTEIN | PAIN | METABOLISM | PHARMACOKINETICS | IN-VIVO | ORAL OXYCODONE | PHARMACOLOGY & PHARMACY | CODEINE | RECEPTOR-BINDING | Cytochrome P-450 CYP2D6 Inhibitors | Humans | Middle Aged | Analgesics, Opioid - pharmacology | Male | Young Adult | Analgesics, Opioid - adverse effects | Drug Interactions | Pain Threshold - drug effects | Adult | Oxycodone - adverse effects | Metabolic Detoxication, Phase I - genetics | Oxymorphone - blood | Cytochrome P-450 CYP2D6 - genetics | Oxycodone - therapeutic use | Reflex, Pupillary - drug effects | Oxycodone - pharmacology | Double-Blind Method | Enzyme Inhibitors - pharmacology | Analgesics, Opioid - therapeutic use | Genotype | Psychomotor Performance - drug effects | Polymorphism, Genetic | Cross-Over Studies | Oxycodone - pharmacokinetics | Phenotype | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Drug therapy | Enzymes | Pain | Pain perception | Ketoconazole | Toxicity | Cytochrome P450 | Gene polymorphism | Electrical stimuli | Side effects | Analgesics | Metabolites | Quinidine | Drug interaction | Oxidation | Pharmacokinetics | CYP2D6 protein | Research Papers
Journal Article
Molecular Diagnosis & Therapy, ISSN 1177-1062, 6/2013, Volume 17, Issue 3, pp. 165 - 184
Interindividual variability in drug response is a major clinical problem. Polymedication and genetic polymorphisms modulating drug-metabolising enzyme... 
Human Genetics | Pharmacotherapy | Cancer Research | Molecular Medicine | Biomedicine | Laboratory Medicine | IMPLEMENTATION CONSORTIUM GUIDELINES | CYP2D6 GENE DUPLICATION | ALLELIC VARIANT | GENETICS & HEREDITY | RESPONSIVE BREAST-CANCER | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | COMBINED PHENOTYPIC ASSESSMENT | HUMAN CYTOCHROME-P450 ENZYMES | ADVERSE DRUG-REACTIONS | DOSE REQUIREMENTS | ACTIVE METABOLITE | Cytochrome P-450 CYP2C9 | Cytochrome P-450 CYP2D6 - genetics | Pharmacogenetics | Psychotropic Drugs - pharmacokinetics | Anti-Arrhythmia Agents - pharmacology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Estrogen Antagonists - pharmacology | Treatment Outcome | Anti-Arrhythmia Agents - metabolism | Anti-Arrhythmia Agents - pharmacokinetics | Antidepressive Agents - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Estrogen Antagonists - metabolism | Cytochrome P-450 CYP2C19 | Psychotropic Drugs - pharmacology | Estrogen Antagonists - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Antidepressive Agents - pharmacology | Inactivation, Metabolic - genetics | Psychotropic Drugs - metabolism | Antidepressive Agents - pharmacokinetics | Measurement | Physiological aspects | Genetic aspects | Drug therapy | Cytochrome P-450 | Psychotropic drugs | Enzymes | Genotype & phenotype | Metabolites | Antidepressants | Clinical medicine | Metabolism | Drug dosages | Patients | Polymorphism | Index Medicus | Review
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2017, Volume 39, Issue 8, pp. e65 - e65
[...]they may inhibit prasugrel and clopidogrel bioactivation pathways and reduce their efficacy. Area Under Concentration-time curve* Wilcoxon signed-rank... 
Internal Medicine | Medical Education | Highly active antiretroviral therapy | Antiviral agents | Antiretroviral drugs | Pharmacodynamics | Metabolites | Antiretroviral agents | Biocompatibility | Clopidogrel | Pharmacology | Pharmacokinetics
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2015, Volume 37, Issue 8, pp. e101 - e101
  Conclusion DBS technique combined with an innovative sampling device and a sensitive analytical method can be used as a self-test for CYP and P-gp... 
Internal Medicine | Medical Education | Blood | Medical examination | Cytochrome | Metabolites | Sampling techniques
Journal Article