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Nature (London), ISSN 1476-4687, 2016, Volume 540, Issue 7633, pp. 458 - 461
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2007, Volume 46, Issue 22, pp. 4132 - 4135
Triple play: The crystallization of 1,4‐diazabicyclo[2.2.2]octane (A) with one, two, or three different 4‐substituted phenols (B, C, D) leads to cocrystals... 
phenols | solid solutions | crystal engineering | supramolecular chemistry | organic alloys | Phenols | Crystal engineering | Solid solutions | Organic alloys | Supramolecular chemistry | DESIGN | CRYSTAL-STRUCTURE | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2016, Volume 7, Issue 3, pp. 283 - 288
Clinical validation of S1P receptor modulation therapy was achieved with the approval of fingolimod (Gilenya, 1) as the first oral therapy for relapsing... 
GPCR | S1P1 | biased signaling | S1P3
Journal Article
MedChemComm, ISSN 2040-2503, 04/2017, Volume 8, Issue 4, pp. 725 - 729
Recently, our research group reported the identification of prodrug amino-alcohol 2 as a potent and efficacious S1P1 receptor modulator. This molecule is... 
Journal Article
Clinical Neurophysiology, ISSN 1388-2457, 07/2019, Volume 130, Issue 7, pp. e116 - e116
Hereditary spastic paraparesis (HSP) is a group of inherited disorders affecting predominantly the motor cortex and pyramidal tract, which results in slowly... 
Medicine, Experimental | Medical research | Seizures (Medicine)
Journal Article
07/2019
Η παρούσα εφεύρεση παρέχει κρυσταλλικές μορφές του (S,Ε)-4-(2-(3-(3-χλωρο-2-φθορο-6-(1Η-τετραζολ-1... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Journal of medicinal chemistry, ISSN 0022-2623, 11/2019, Volume 62, Issue 22, pp. 10456 - 10465
The APJ receptor and its endogenous peptidic ligand apelin have been implicated as important modulators of cardiovascular function, and APJ receptor agonists... 
SYSTEM | APELIN | CHEMISTRY, MEDICINAL | LIGAND | DISCOVERY
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2018, Volume 28, Issue 2, pp. 85 - 93
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2020, Volume 30, Issue 7, p. 126955
[Display omitted] This article describes the discovery of aryl hydroxy pyrimidinones and the medicinal chemistry efforts to optimize this chemotype for potent... 
Heart failure | GPCR | Agonist | APJ | Atropisomer | CHEMISTRY, MEDICINAL | ANALOGS | CHEMISTRY, ORGANIC | APELIN | RECEPTOR | LIGAND
Journal Article
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