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by George, Julie and Lim, Jing Shan and Jang, Se Jin and Cun, Yupeng and Ozretia, Luka and Kong, Gu and Leenders, Frauke and Lu, Xin and Fernández-Cuesta, Lynnette and Bosco, Graziella and Müller, Christian and Dahmen, Ilona and Jahchan, Nadine S and Park, Kwon-Sik and Yang, Dian and Karnezis, Anthony N and Vaka, Dedeepya and Torres, Angela and Wang, Maia Segura and Korbel, Jan O and Menon, Roopika and Chun, Sung-Min and Kim, Deokhoon and Wilkerson, Matt and Hayes, Neil and Engelmann, David and Pützer, Brigitte and Bos, Marc and Michels, Sebastian and Vlasic, Ignacija and Seidel, Danila and Pinther, Berit and Schaub, Philipp and Becker, Christian and Altmüller, Janine and Yokota, Jun and Kohno, Takashi and Iwakawa, Reika and Tsuta, Koji and Noguchi, Masayuki and Muley, Thomas and Hoffmann, Hans and Schnabel, Philipp A and Petersen, Iver and Chen, Yuan and Soltermann, Alex and Tischler, Verena and Choi, Chang-Min and Kim, Yong-Hee and Massion, Pierre P and Zou, Yong and Jovanovic, Dragana and Kontic, Milica and Wright, Gavin M and Russell, Prudence A and Solomon, Benjamin and Koch, Ina and Lindner, Michael and Muscarella, Lucia A and La Torre, Annamaria and Field, John K and Jakopovic, Marko and Knezevic, Jelena and Castaños-Vélez, Esmeralda and Roz, Luca and Pastorino, Ugo and Brustugun, Odd-Terje and Lund-Iversen, Marius and Thunnissen, Erik and Köhler, Jens and Schuler, Martin and Botling, Johan and Sandelin, Martin and Sanchez-Cespedes, Montserrat and Salvesen, Helga B and Achter, Viktor and Lang, Ulrich and Bogus, Magdalena and Schneider, Peter M and Zander, Thomas and Ansén, Sascha and Hallek, Michael and Wolf, Jürgen and Vingron, Martin and Yatabe, Yasushi and Travis, William D and Nürnberg, Peter and Reinhardt, Christian and Perner, Sven and Heukamp, Lukas and Büttner, Reinhard and Haas, Stefan A and Brambilla, Elisabeth and Peifer, Martin and Sage, Julien and Thomas, Roman K and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 47 - 53
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic... 
NEUROENDOCRINE TUMORS | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | GENES | CYCLE ARREST | NOTCH | C-KIT | MUTATIONS | CARCINOMA | Neurosecretory Systems - pathology | Receptors, Notch - metabolism | Chromosome Breakpoints | Genomics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Receptors, Notch - genetics | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Tumor Suppressor Proteins - genetics | Neurosecretory Systems - metabolism | Female | Nuclear Proteins - genetics | Disease Models, Animal | Lung Neoplasms - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Genome, Human - genetics | Small Cell Lung Carcinoma - pathology | Tumor Protein p73 | Animals | Cyclin D1 - genetics | Retinoblastoma Protein - genetics | Alleles | Cell Line, Tumor | Mice | Gene mutations | Analysis | Exome sequencing | Lung cancer, Small cell | Genetic aspects | Drug therapy | Cancer | Pathogenesis | Lung cancer | Genomes | Mutation | Kinases | Gene expression | Cancer therapies | Tumors | Clinical Medicine | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
by Peifer, Martin and Fernández-Cuesta, Lynnette and Sos, Martin L and George, Julie and Seidel, Danila and Kasper, Lawryn H and Plenker, Dennis and Leenders, Frauke and Sun, Ruping and Zander, Thomas and Menon, Roopika and Koker, Mirjam and Dahmen, Ilona and Müller, Christian and Di Cerbo, Vincenzo and Schildhaus, Hans-Ulrich and Altmüller, Janine and Baessmann, Ingelore and Becker, Christian and De Wilde, Bram and Vandesompele, Jo and Böhm, Diana and Ansén, Sascha and Gabler, Franziska and Wilkening, Ines and Heynck, Stefanie and Heuckmann, Johannes M and Lu, Xin and Carter, Scott L and Cibulskis, Kristian and Banerji, Shantanu and Getz, Gad and Park, Kwon-Sik and Rauh, Daniel and Grütter, Christian and Fischer, Matthias and Pasqualucci, Laura and Wright, Gavin and Wainer, Zoe and Russell, Prudence and Petersen, Iver and Chen, Yuan and Stoelben, Erich and Ludwig, Corinna and Schnabel, Philipp and Hoffmann, Hans and Muley, Thomas and Brockmann, Michael and Engel-Riedel, Walburga and Muscarella, Lucia A and Fazio, Vito M and Groen, Harry and Timens, Wim and Sietsma, Hannie and Thunnissen, Erik and Smit, Egber and Heideman, Daniëlle A. M and Snijders, Peter J. F and Cappuzzo, Federico and Ligorio, Claudia and Damiani, Stefania and Field, John and Solberg, Steinar and Brustugun, Odd Terje and Lund-Iversen, Marius and Sänger, Jörg and Clement, Joachim H and Soltermann, Alex and Moch, Holger and Weder, Walter and Solomon, Benjamin and Soria, Jean-Charles and Validire, Pierre and Besse, Benjamin and Brambilla, Elisabeth and Brambilla, Christian and Lantuejoul, Sylvie and Lorimier, Philippe and Schneider, Peter M and Hallek, Michael and Pao, William and Meyerson, Matthew and Sage, Julien and Shendure, Jay and Schneider, Robert and Büttner, Reinhard and Wolf, Jürgen and Nürnberg, Peter and Perner, Sven and Heukamp, Lukas C and Brindle, Paul K and Haas, Stefan and Thomas, Roman K
Nature Genetics, ISSN 1061-4036, 10/2012, Volume 44, Issue 10, pp. 1104 - 1110
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 3518
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 18, pp. 5527 - 5536
Purpose: The 8p12-p11 locus is frequently amplified in squamous cell lung cancer (SQLC); the receptor tyrosine kinase fibroblast growth factor receptor 1... 
DOSE-ESCALATION | SELECTIVE INHIBITOR | GEFITINIB | POTENT | ADVANCED SOLID TUMORS | AMPLIFICATION | ONCOLOGY | ACQUIRED-RESISTANCE | CRIZOTINIB | PHASE-I | RECEPTOR TYROSINE KINASE | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Translocation, Genetic | Membrane Proteins - genetics | Humans | Proto-Oncogene Proteins c-met | Tomography, X-Ray Computed | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Biomarkers, Tumor | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Gene Amplification | GTP Phosphohydrolases - genetics | Cell Line, Tumor | Protein Binding | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Lung Neoplasms - diagnosis | Disease Models, Animal | Fibroblast growth factor | Biotechnology | Transcription | Lung cancer | Activation | Drug resistance | Drug development | c-Met protein | Clonal deletion | Deletion | Protein-tyrosine kinase receptors | Inhibition | Fibroblast growth factor receptor 1 | Protein-tyrosine kinase | Tyrosine | Subpopulations | Tumor cells | MAP kinase | Shrinkage | Tumor cell lines | Amplification | Inhibitors | Experimental design | Cell lines | Chromosome 8 | Viability | Tumors | Cancer | Fibroblast growth factor receptors
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1048 - 13
Journal Article
Genome Biology, ISSN 1474-7596, 01/2015, Volume 16, Issue 1, pp. 7 - 7
Journal Article
by Seidel, Danila and Zander, Thomas and Heukamp, Lukas C and Peifer, Martin and Bos, Marc and Fernandez-Cuesta, Lynnette and Leenders, Frauke and Lu, Xin and Ansen, Sascha and Gardizi, Masyar and Nguyen, Chau and Berg, Johannes and Russell, Prudence and Wainer, Zoe and Schildhaus, Hans-Ulrich and Rogers, Toni-Maree and Solomon, Benjamin and Pao, William and Carter, Scott L and Getz, Gad and Hayes, D. Neil and Wilkerson, Matthew D and Thunnissen, Erik and Travis, William D and Perner, Sven and Wright, Gavin and Brambilla, Elisabeth and Buettner, Reinhard and Wolf, Juergen and Thomas, Roman and Gabler, Franziska and Wilkening, Ines and Mueller, Christian and Dahmen, Ilona and Menon, Roopika and Koenig, Katharina and Albus, Kerstin and Merkelbach-Bruse, Sabine and Fassunke, Jana and Schmitz, Katja and Kuenstlinger, Helen and Kleine, Michaela and Binot, Elke and Querings, Silvia and Altmueller, Janine and Boessmann, Ingelore and Nuemberg, Peter and Schneider, Peter and Bogus, Magdalena and Soltermann, Alex and Moch, Holger and Brustugun, Odd Terje and Solberg, Steinar and Lund-Iversen, Marius and Helland, Aslaug and Muley, Thomas and Hoffmann, Hans and Schnabel, Philipp A and Chen, Yuan and Groen, Harry and Timens, Wim and Sietsma, Hannie and Clement, Joachim H and Weder, Walter and Saenger, Joerg and Stoelben, Erich and Ludwig, Corinna and Engel-Riedel, Walburga and Smit, Egbert and Heideman, Danille A. M and Snijders, Peter J. F and Nogova, Lucia and Sos, Martin L and Mattonet, Christian and Toepelt, Karin and Scheffler, Matthias and Goekkurt, Eray and Kappes, Rainer and Krueger, Stefan and Kambartel, Kato and Behringer, Dirk and Schulte, Wolfgang and Galetke, Wolfgang and Randerath, Winfried and Heldwein, Matthias and Schlesinger, Aneas and Serke, Monika and Hekmat, Khosro and Frank, Konrad F and Schnell, Roland and Reiser, Marcel and Huenerlituerkoglu, Ali-Nuri and Schmitz, Stephan and Meffert, Lisa and Ko, Yon-Dschun and Litt-Lampe, Markus and Gerigk, Ulrich and Fricke, Rainer and Besse, Benjamin and Brambilla, Christian and ... and CLCGP and NGM and Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM) and The Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM)
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra153 - 209ra153
We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically... 
MEDICINE, RESEARCH & EXPERIMENTAL | GEFITINIB | FUSION | GENE | NRF2 | ADENOCARCINOMA | OPEN-LABEL | SQUAMOUS-CELL CARCINOMAS | CANCER | ACTIVATING MUTATIONS | DRIVER MUTATIONS | CELL BIOLOGY | Lung Neoplasms - genetics | Lung Neoplasms - classification | Automation | Genomics | Humans | Lung Neoplasms - pathology | Lung Neoplasms - diagnosis | Genome, Human - genetics
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 4, pp. 415 - 422
Journal Article