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Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 10433 - 11
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2016, Volume 55, Issue 2, pp. 201 - 212
Human immunodeficiency virus (HIV)-related pulmonary arterial hypertension has been found to be more prevalent in intravenous drug users. Our earlier... 
Pulmonary hypertension; drug abuse; smooth muscle; bone morphogenetic protein receptor; human immunodeficiency virus-1 | bone morphogenetic protein receptor | OXIDATIVE STRESS | RISK-FACTORS | pulmonary hypertension | BIOCHEMISTRY & MOLECULAR BIOLOGY | smooth muscle | DOWN-REGULATION | CELL BIOLOGY | human immunodeficiency virus-1 | drug abuse | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | HIV-1 TAT | SMOOTH-MUSCLE-CELLS | TYPE-1 TAT PROTEIN | MORPHOGENETIC PROTEIN-RECEPTOR | INFECTED MACAQUES | HIV - physiology | Apoptosis - drug effects | Humans | Rats, Inbred F344 | Myocytes, Smooth Muscle - pathology | Systole - drug effects | Male | Viral Proteins - metabolism | HIV - drug effects | Lung - virology | Blood Pressure - drug effects | Lung - metabolism | Vascular Remodeling - drug effects | Cocaine - adverse effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Rats, Transgenic | Cell Separation | Bone Morphogenetic Protein Receptors - metabolism | Lung - physiopathology | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Down-Regulation - drug effects | Rats, Sprague-Dawley | Muscle, Smooth, Vascular - pathology | Animals | Signal Transduction - drug effects | Lung - drug effects | Cell Proliferation - drug effects | Hemodynamics - drug effects | Hypertension | Heart | Pulmonary arteries | Laboratories | Diagnostic tests | Mortality | Smooth muscle | Infections | Proteins | Hepatitis | Rodents | Human immunodeficiency virus--HIV | Protein expression | Cocaine | Intubation | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85246
Intravenous drug use (IVDU) is the major risk factor in the development of HIV-related pulmonary arterial hypertension (HRPAH); however, the pathogenesis of... 
KINASE-ACTIVITY | NADPH OXIDASE | H2O2-MEDIATED PERMEABILITY | TYROSINE PHOSPHORYLATION | IMMUNODEFICIENCY-VIRUS | MULTIDISCIPLINARY SCIENCES | HIV-1 TAT PROTEIN | ARTERIAL-HYPERTENSION | HYDROGEN-PEROXIDE | GROWTH-FACTOR | BLOOD-BRAIN-BARRIER | Reactive Oxygen Species - metabolism | Humans | NADPH Oxidases - metabolism | Capillary Permeability - drug effects | Capillary Permeability - genetics | Gene Knockdown Techniques | MAP Kinase Signaling System | Lung - virology | NADPH Oxidases - genetics | Lung - metabolism | Zonula Occludens-1 Protein - metabolism | Endothelial Cells - virology | Receptors, sigma - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | HIV-1 - metabolism | Endothelial Cells - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Antioxidants - pharmacology | Cocaine - pharmacology | tat Gene Products, Human Immunodeficiency Virus - pharmacology | Lung - drug effects | Protein Binding | Oxidative Stress - drug effects | Lung - blood supply | Endothelial Cells - drug effects | tat Gene Products, Human Immunodeficiency Virus - metabolism | Oxidases | Proteins | Development and progression | Cocaine | Superoxide | Permeability | Comparative analysis | HIV (Viruses) | Pulmonary hypertension | Endothelium | Oxidative stress | Drug abuse | Reactive oxygen species | Animal models | Hydrogen peroxide | Intravenous administration | Transcription | Pathogenesis | Oxidase | Membrane permeability | Critical care | Raf protein | Smooth muscle | Biosynthesis | Infections | Kinases | Remodeling | Radicals | NAD(P)H oxidase | Risk factors | Antioxidants | Signal transduction | Scholarships & fellowships | Rodents | Human immunodeficiency virus--HIV | Pretreatment | Growth factors | Drug use | Hypertension | Narcotics | Health risks | Extracellular signal-regulated kinase | Ras protein | siRNA | Exposure | Pulmonary artery | Endothelial cells | Medicine | Tat protein | Signaling | Microvasculature | Dismantling | Viral infections | HIV | Human immunodeficiency virus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2013, Volume 33, Issue 11, pp. 2585 - 2595
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 11/2013, Volume 33, Issue 11
gp-120 | SMAD | BMP | IVDU | Tat | Nef
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2012, Volume 185, Issue 11, pp. 1235 - 1243
Journal Article
Journal Article
AIDS (London, England), ISSN 1473-5571, 2018, Volume 32, Issue 18, pp. 2651 - 2667
: Improved survival among HIV-1-infected individuals with the advent of antiretroviral therapy has clearly led to a greater prevalence of noninfectious... 
INFECTIOUS DISEASES | LUNG ENDOTHELIAL-CELLS | TGF-BETA | PROGNOSTIC-FACTORS | cocaine | ECHOCARDIOGRAPHIC ABNORMALITIES | IMMUNOLOGY | vascular remodeling | HUMAN-IMMUNODEFICIENCY-VIRUS | NONHUMAN PRIMATE MODEL | VIROLOGY | HIV | ACTIVE ANTIRETROVIRAL THERAPY | ARTERIAL-HYPERTENSION | SMOOTH-MUSCLE-CELLS | opioids | TENASCIN-C
Journal Article
Autophagy, ISSN 1554-8627, 12/2016, Volume 12, Issue 12, pp. 2420 - 2438
Intravenous drug use is one of the major risk factors for HIV-infection in HIV-related pulmonary arterial hypertension patients. We previously demonstrated... 
apoptosis | endothelial cells | autophagy | HIV-Tat | proliferation | morphine | CANCER-CELLS | OXIDATIVE STRESS | ANGIOGENESIS | PERMEABILITY | RECEPTOR | CELL BIOLOGY | PROTEIN-LEVELS | INHIBITION | INFECTION | GROWTH-FACTOR | Substance Abuse, Intravenous - pathology | Apoptosis - drug effects | Recombinant Fusion Proteins - adverse effects | Humans | Microvessels - pathology | Apoptosis - genetics | RNA, Messenger - metabolism | Autophagy - drug effects | Autophagosomes - drug effects | Endothelial Cells - ultrastructure | Simian Acquired Immunodeficiency Syndrome - virology | tat Gene Products, Human Immunodeficiency Virus - adverse effects | Lysosomes - metabolism | HIV Infections - pathology | Macaca | Autophagy - genetics | Substance Abuse, Intravenous - complications | Simian Acquired Immunodeficiency Syndrome - pathology | Biomarkers - metabolism | Lysosomes - drug effects | Lung - pathology | Endothelial Cells - metabolism | RNA, Messenger - genetics | Autophagosomes - metabolism | Autophagosomes - ultrastructure | Simian Immunodeficiency Virus - physiology | Lysosomes - ultrastructure | Animals | Models, Biological | HIV Infections - complications | Substance Abuse, Intravenous - virology | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Hypertension, Pulmonary - virology | Oxidative Stress - drug effects | Endothelial Cells - pathology | Hypertension, Pulmonary - pathology | Morphine - adverse effects | Apoptosis Regulatory Proteins - adverse effects | Hypertension, Pulmonary - complications
Journal Article
Journal of Extracellular Vesicles, 01/2018, Volume 7, pp. 31 - 32
Background: Our previous studies consistently demonstrate enhanced pulmonary vascular remodelling in HIV-1-infected individuals, simian immunodeficiency... 
Cell proliferation | Drug abuse | Hydrogen | MiRNA | Smooth muscle | AKT protein | Ultracentrifugation | Inflammation | Gene expression | Macrophages | 1-Phosphatidylinositol 3-kinase | Monocytes | Vesicles | Human immunodeficiency virus--HIV | Cocaine | PTEN protein
Journal Article
Journal of Extracellular Vesicles, 01/2018, Volume 7, pp. 174 - 174
Background: Our previous studies consistently demonstrate enhanced pulmonary vascular remodelling in HIV-1 infected individuals, simian immunodeficiency... 
Cell proliferation | Drug abuse | MiRNA | Smooth muscle | AKT protein | Ultracentrifugation | Inflammation | Gene expression | Macrophages | 1-Phosphatidylinositol 3-kinase | Monocytes | Vesicles | Human immunodeficiency virus--HIV | Cocaine | PTEN protein
Journal Article