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1. Full Text The role of CXC chemokines and their receptors in cancer
by Vandercappellen, Jo and Van Damme, Jo and Struyf, Sofie
Cancer Letters, ISSN 0304-3835, 2008, Volume 267, Issue 2, pp. 226 - 244
Abstract Chemokines, or chemotactic cytokines, and their receptors have been discovered as essential and selective mediators in leukocyte migration to... 
Hematology, Oncology and Palliative Medicine | Angiogenesis | GPCR | Tumorigenesis | Metastasis | Chemokines | Cancer | ACTIVATING PEPTIDE-III | angiogenesis | SARCOMA-ASSOCIATED HERPESVIRUS | MICROVASCULAR ENDOTHELIAL-CELLS | DUFFY ANTIGEN RECEPTOR | chemokines | GRANULOCYTE CHEMOTACTIC PROTEIN-2 | AMINO-ACID-SEQUENCE | ONCOLOGY | metastasis | GROWTH STIMULATORY ACTIVITY | METASTATIC BREAST-CANCER | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer | tumorigenesis | PLATELET FACTOR-IV | Receptors, CXCR - genetics | Humans | Chemokines, CXC - genetics | Amino Acid Motifs | Neoplasms - therapy | Animals | Neoplasms - immunology | Receptors, CXCR - metabolism | Chemokines, CXC - metabolism | Chemokines, CXC - physiology | Mice | Protein Processing, Post-Translational | Receptors, CXCR - physiology | Squamous cell carcinoma | Registered nurses | Glycosaminoglycans | Sarcoma | Development and progression | Glutamate | T cells | Biological response modifiers | Lung cancer, Non-small cell | Membrane proteins | Lymphomas | Fibroblast growth factors | G proteins | Vascular endothelial growth factor | Health aspects | Proteins | Leucocytes | Migration | Cancer therapies | Molecular weight | Immune system | Tumors
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2. Full Text Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas
by Van Damme, Nancy and Deron, Philippe and Van Roy, Nadine and Demetter, Pieter and Bols, Alain and Dorpe, Jo Van and Baert, Filip and Van Laethem, Jean-Luc and Speleman, Franki and Pauwels, Patrick and Peeters, Marc
BMC Cancer, ISSN 1471-2407, 05/2010, Volume 10, Issue 1, pp. 189 - 189
Background: With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and... 
GENE-MUTATIONS | LUNG-CANCER | HEAD | CETUXIMAB | ONCOLOGY | COLORECTAL-CANCER | COPY NUMBER | HUMAN-PAPILLOMAVIRUS | EXPRESSION | ACTIVATING MUTATIONS | EGFR KINASE DOMAIN | Immunohistochemistry | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Exons | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Molecular Sequence Data | Male | Anal Canal - chemistry | Tonsillar Neoplasms - metabolism | DNA Mutational Analysis | Base Sequence | Polymerase Chain Reaction | Aged, 80 and over | Adult | Female | Anal Canal - pathology | Tonsillar Neoplasms - pathology | Anus Neoplasms - metabolism | Biomarkers, Tumor - analysis | Tonsillar Neoplasms - genetics | In Situ Hybridization, Fluorescence | Proto-Oncogene Proteins - genetics | Anus Neoplasms - pathology | Receptor, Epidermal Growth Factor - analysis | Gene Amplification | Belgium | Anus Neoplasms - genetics | Aged | Biomarkers, Tumor - genetics | Mutation | Cohort Studies | Squamous cell carcinoma | Care and treatment | Ras genes | Gene mutations | Physiological aspects | Genetic aspects | Research | Growth factor receptors | Health aspects | Risk factors
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3. Full Text Immunomodulation as Rescue for Chronic Atonic Skin Wounds
by Opdenakker, Ghislain and Van Damme, Jo and Vranckx, Jan Jeroen
Trends in Immunology, ISSN 1471-4906, 04/2018, Volume 39, Issue 4, pp. 341 - 354
Chronic skin wounds, caused by arterial or venous insufficiency or by physical pressure, constitute an increasing medical problem as populations age. Whereas... 
DIABETES-MELLITUS | MATRIX METALLOPROTEINASES | CHRONIC VENOUS DISEASE | CYTOKINES | NEUTROPHIL | INFLAMMATION | TISSUE REGENERATION | GELATINASE B | POSTTRANSLATIONAL MODIFICATIONS | INHIBITORS | IMMUNOLOGY | Animals | Cytokines - metabolism | Immunomodulation | Humans | Matrix Metalloproteinases | Skin Diseases - immunology | Wound Healing | Chronic Disease | Skin - pathology | Complement System Proteins - metabolism | Health care | Enzymes | Wound healing | Matrix metalloproteinases | Cytokines | Inflammation | Research | Substrates | Defects | Pathology | Angiogenesis | Immunology | Ulcers | Surgery | Stem cells | Healing | Skin | Infiltration | Diabetes | Chemokines
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4. Structure and expression of different serum amyloid a (saa) variants and their concentration-dependent functions during host insults
by De Buck, Mieke and Gouwy, Mieke and Wang, Ji Ming and Van Snick, Jacques and Opdenakker, Ghislain and Struyf, Sofie and Van Damme, Jo
Current Medicinal Chemistry, ISSN 0929-8673, 05/2016, Volume 23, Issue 17, pp. 1725 - 1755
Serum amyloid A (SAA) is, like C-reactive protein (CRP), an acute phase protein and can be used as a diagnostic, prognostic or therapy follow-up marker for... 
Cytokines | Amyloidosis | FPR2 | Leukocytes | Saa variants | Chemotaxis | Inflammatory diseases | TLR2 | C-REACTIVE PROTEIN | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CHEMISTRY, MEDICINAL | amyloidosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | inflammatory diseases | NECROSIS-FACTOR-ALPHA | HIGH-DENSITY-LIPOPROTEIN | PREMATURE CORONARY ATHEROSCLEROSIS | OBSTRUCTIVE PULMONARY-DISEASE | ACUTE-PHASE PROTEINS | FORMYL PEPTIDE RECEPTOR | SAA variants | leukocytes | PHARMACOLOGY & PHARMACY | cytokines | NF-KAPPA-B | SIGNAL-TRANSDUCTION PATHWAY | chemotaxis | Genomic Structural Variation - genetics | Serum Amyloid A Protein - genetics | Serum Amyloid A Protein - chemistry | Serum Amyloid A Protein - metabolism | Humans
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5. Full Text The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer
by Vandercappellen, Jo and Van Damme, Jo and Struyf, Sofie
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2010, Volume 22, Issue 1, pp. 1 - 18
Abstract Chemokines are chemotactic cytokines which recruit leukocytes to inflammatory sites. They also affect tumor development and metastasis by acting as... 
Advanced Basic Science | Chemokine | Angiogenesis | Platelet factor-4 variants | CXCR3 | Cancer | ENDOTHELIAL-CELL PROLIFERATION | ACTIVATED PROTEIN-C | MURINE CEREBRAL MALARIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | HEPARIN-INDUCED THROMBOCYTOPENIA | FIBROBLAST-GROWTH-FACTOR | HUMAN MONOCYTES | CELL BIOLOGY | AMINO-ACID-SEQUENCE | IN-VIVO | PLATELET FACTOR-IV
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6. Full Text Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines
by Gouwy, Mieke and Buck, Mieke and Pörtner, Noëmie and Opdenakker, Ghislain and Proost, Paul and Struyf, Sofie and Damme, Jo
European Journal of Immunology, ISSN 0014-2980, 01/2015, Volume 45, Issue 1, pp. 101 - 112
Serum amyloid A (SAA) is an acute phase protein that is upregulated in inflammatory diseases and chemoattracts monocytes, lymphocytes, and granulocytes via its... 
Serum amyloid A | Monocytes | DCs | Chemotaxis | Chemokines | MIGRATION | A-PROTEIN | ACTIVATION | RELEASE | IMMUNOLOGY | IDENTIFICATION | ACUTE-PHASE RESPONSE | PROTEIN-COUPLED RECEPTOR | PATHWAY | DISEASE | EXPRESSION | Interleukin-8 - genetics | Dose-Response Relationship, Immunologic | Chemokine CCL3 - immunology | Monocytes - cytology | Serum Amyloid A Protein - pharmacology | Dendritic Cells - immunology | Humans | Receptors, CCR5 - genetics | Monocytes - immunology | Chemokine CCL3 - antagonists & inhibitors | Interleukin-8 - agonists | Receptors, CCR5 - immunology | Chemokine CCL3 - genetics | Dendritic Cells - drug effects | Receptors, CCR1 - immunology | Chemotaxis - immunology | Cell Line | Signal Transduction | Gene Expression Regulation | Antibodies, Neutralizing - pharmacology | Chemotaxis - drug effects | Interleukin-8 - antagonists & inhibitors | Recombinant Proteins - pharmacology | Monocytes - drug effects | Receptors, CCR1 - genetics | Diffusion Chambers, Culture | Chemokine CXCL12 - pharmacology | Dendritic Cells - cytology | Primary Cell Culture | Interleukin-8 - immunology | Receptors, CCR1 - antagonists & inhibitors | G proteins | Peptides | Dendritic cells | Membrane proteins | Proteins | Leucocytes | Ligands
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7. Full Text The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer
by Hannelien, Verbeke and Karel, Geboes and Jo, Van Damme and Sofie, Struyf
BBA - Reviews on Cancer, ISSN 0304-419X, 2012, Volume 1825, Issue 1, pp. 117 - 129
Chronic inflammation may increase the risk to develop cancer, for instance esophagitis or gastritis may lead to development of esophageal or gastric cancer,... 
Chemokine | Esophagitis | Angiogenesis | Inflammation | Cancer | Gastritis | INDUCED INTERLEUKIN-8 PRODUCTION | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | BARRETTS-ESOPHAGUS | NEUTROPHIL-ACTIVATING PROPERTIES | BIOPHYSICS | LYMPH-NODE METASTASIS | EPITHELIAL-CELLS | ONCOLOGY | HELICOBACTER-PYLORI INFECTION | EPIDERMAL-GROWTH-FACTOR | Care and treatment | Oncology, Experimental | Gastrointestinal system | Development and progression | Research | Neovascularization | Stomach cancer | Esophageal cancer | Tumors
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8. Full Text Regulation of chemokine activity - A focus on the role of dipeptidyl peptidase IV/CD26
by Metzemaekers, Mieke and Van Damme, Jo and Mortier, Anneleen and Proost, Paul
Frontiers in Immunology, ISSN 1664-3224, 11/2016, Volume 7, p. 483
Chemokines are small, chemotactic proteins that play a crucial role in leukocyte migration and are, therefore, essential for proper functioning of the immune... 
Chemokine | Posttranslational modification | Leukocyte migration | Proteolysis | Glycosaminoglycan | GPCR | CD26 | Dipeptidyl peptidase IV | chemokine | MACROPHAGE-DERIVED CHEMOKINE | COLONY-STIMULATING FACTOR | posttranslational modification | leukocyte migration | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | NEUROPEPTIDE-Y NPY | MYELIN BASIC-PROTEIN | MATRIX METALLOPROTEINASES | CHEMOTACTIC ACTIVITY | IN-VIVO | dipeptidyl peptidase IV | glycosaminoglycan | AMINO-TERMINAL TRUNCATION | proteolysis | ENDOTHELIAL GROWTH-FACTOR | Research | Proteases | Analysis | Chemokines
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