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1. Full Text Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength
by Cha, Hye-Na and Park, Soyoung and Dan, Yongwook and Kim, Jae-Ryong and Park, So-Young
The Journals of Gerontology: Series A, ISSN 1079-5006, 01/2019, Volume 74, Issue 2, pp. 147 - 154
Abstract This study examined the role of peroxiredoxin2 (Prx2) in aging-induced insulin resistance and reduction in skeletal muscle function in young... 
Oxidative stress | Hyperinsulinemic-euglycemic clamp | Skeletal muscle | p53 | METHIONINE SULFOXIDE REDUCTASE | II PRX-II | TISSUE | MOUSE | GERIATRICS & GERONTOLOGY | PATHOGENESIS | SKELETAL-MUSCLE | GERONTOLOGY | TUMOR-SUPPRESSOR | NF-KAPPA-B
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2. Clusterin deficiency induces lipid accumulation and tissue damage in kidney
by Heo, Jung-Yoon and Kim, Ji-Eun and Dan, Yongwook and Kim, Yong-Woon and Kim, Jong-Yeon and Cho, Kyu Hyang and Bae, Young Kyung and Im, Seung-Soon and Liu, Kwang-Hyeon and Song, In-Hwan and Kim, Jae-Ryong and Lee, In-Kyu and Park, So-Young
Journal of Endocrinology, ISSN 0022-0795, 05/2018, Volume 237, Issue 2, pp. 175 - 191
Clusterin is a secretory glycoprotein that is involved in multiple physiopathological processes, including lipid metabolism. Previous studies have shown that... 
Chronic kidney disease | SREBP | TGFB1 | Lipid metabolism | Clusterin | clusterin | chronic kidney disease | ELEMENT-BINDING PROTEIN-1 | HIGH-FAT DIET | lipid metabolism | ACID OXIDATION | DIABETES-MELLITUS | OBESITY | MESSENGER-RNA | METABOLISM | MALONYL-COA | ENDOCRINOLOGY & METABOLISM | UP-REGULATION | EXPRESSION | Creatinine | Kidneys | Transforming growth factor-b1 | Epithelial cells | Therapeutic applications | Malonyl-CoA decarboxylase | Lipids | Gene expression | Metabolism | Proteins | Rodents | Fibrosis | Sterol regulatory element-binding protein | Oxidation | Kidney diseases
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3. Full Text Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations
by Rockah-Shmuel, Liat and Tóth-Petróczy, Ágnes and Tawfik, Dan S
PLoS Computational Biology, ISSN 1553-734X, 08/2015, Volume 11, Issue 8, pp. e1004421 - e1004421
Systematic mappings of the effects of protein mutations are becoming increasingly popular. Unexpectedly, these experiments often find that proteins are... 
SINGLE AMINO-ACID | IN-VITRO | HIGH-THROUGHPUT | FUNCTIONAL IMPACT | BETA-LACTAMASE | SEQUENCE SPACE | MOLECULAR EVOLUTION | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | FITNESS LANDSCAPE | MISSENSE MUTATIONS | Proteins - genetics | Mutation - physiology | Computational Biology - methods | DNA Modification Methylases - genetics | Genetic Drift | Haemophilus - genetics | Bacterial Proteins - genetics | Models, Genetic | Mutation - genetics | Evolution, Molecular | Index Medicus | Proteins | Accuracy | Algorithms | Mutagenesis | Laboratories | Evolution | Mutation | Experiments
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4. Full Text Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations
: e1004421
by Liat Rockah-Shmuel and Ágnes Tóth-Petróczy and Dan S Tawfik
PLoS Computational Biology, ISSN 1553-734X, 08/2015, Volume 11, Issue 8
  Systematic mappings of the effects of protein mutations are becoming increasingly popular. Unexpectedly, these experiments often find that proteins are... 
Proteins | Accuracy | Algorithms | Mutagenesis | Laboratories | Evolution | Mutation | Experiments
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5. Full Text Systematic mapping of protein mutational space by prolonged drift reveals the deleterious effects of seemingly neutral mutations.(RESEARCH ARTICLE)
by Rockah-Shmuel, Liat and Toth-Petroczy, Agnes and Tawfik, Dan S
PLoS Computational Biology, ISSN 1553-734X, 08/2015, Volume 11, Issue 8
Physiological aspects | Chromosome mapping | Gene mutations | Methyltransferases | Observations | Methods
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