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Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 305 - 331
The identification of heterozygous mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) in subsets of cancers, including secondary glioblastoma,... 
cancer therapeutics | allosteric inhibition | metabolism | oncometabolite | Allosteric inhibition | Cancer therapeutics | Metabolism | Oncometabolite | GLIOMA-CELLS | SELECTIVE-INHIBITION | RAT-LIVER | MUTANT IDH1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | REDUCTIVE CARBOXYLATION | POTENT INHIBITOR | ISOTOPOMER ANALYSIS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | CARBON-DIOXIDE | Glutarates - analysis | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Enzyme Inhibitors - chemical synthesis | Isocitrate Dehydrogenase - antagonists & inhibitors | Benzeneacetamides - chemical synthesis | Acetamides - chemical synthesis | Leukemia, Myeloid, Acute - enzymology | Benzeneacetamides - therapeutic use | Acetamides - therapeutic use | Isoenzymes - metabolism | Biomarkers, Tumor - metabolism | Leukemia, Myeloid, Acute - drug therapy | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Benzimidazoles - therapeutic use | Gene Expression | Biomarkers, Tumor - analysis | Isoenzymes - genetics | Leukemia, Myeloid, Acute - pathology | Benzimidazoles - chemical synthesis | Translational Medical Research | Small Molecule Libraries - therapeutic use | Models, Molecular | Small Molecule Libraries - chemical synthesis | Isocitrate Dehydrogenase - genetics | Drug Discovery | Enzyme Inhibitors - therapeutic use | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mutation | Isoenzymes - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Gene mutations | Physiological aspects | Genetic aspects | Oxidoreductases | Research | Antineoplastic agents
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 11, pp. 874 - 875
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 622 - 626
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter... 
Molecules | Enzymes | Dehydrogenases | Blasts | Myeloid leukemia | REPORTS | Stem cells | Bone marrow cells | Cellular differentiation | Hematopoietic stem cells | Mesenchymal stem cells | ISOCITRATE DEHYDROGENASE | ONCOMETABOLITE 2-HYDROXYGLUTARATE | SUFFICIENT | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC PROGENITORS | MUTATION | Cell Proliferation | Humans | Protein Multimerization | Crystallography, X-Ray | Erythropoiesis - drug effects | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Hematopoiesis - drug effects | Antineoplastic Agents - metabolism | Leukemia, Myeloid, Acute - enzymology | Phenylurea Compounds - chemistry | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Mutant Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Sulfonamides - chemistry | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Point Mutation | Isocitrate Dehydrogenase - chemistry | Small Molecule Libraries | Mutant Proteins - chemistry | Allosteric Site | Sulfonamides - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Phenylurea Compounds - pharmacology | Leukemia, Erythroblastic, Acute | Leukemia, Myeloid, Acute - genetics | Leukemia | Cancer cells | Physiological aspects | Research | Oxidoreductases | Cell differentiation | Health aspects | Mutation | Cellular biology | Drug therapy | Cells
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7274, pp. 739 - 744
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 10, pp. 839 - 847
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2005, Volume 11, Issue 1, pp. 28 - 40
Constitutive activation of the NF-κB pathway is required for survival of the activated B cell–like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL).... 
NF-κB | PS-1145 | microarrays | TRANSCRIPTION FACTORS | ACTIVATION | ONCOLOGY | INDUCED APOPTOSIS | DISEASE | DRUG DEVELOPMENT | ALPHA | INDUCTION | HODGKIN/REED-STERNBERG CELLS | CANCER | HUMAN MULTIPLE-MYELOMA
Journal Article