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Science, ISSN 0036-8075, 8/2004, Volume 305, Issue 5687, pp. 1163 - 1167
Gefitinib (Iressa, AstraZeneca Pharmaceuticals) is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR) and induces dramatic... 
Phosphorylation | Receptors | Cell lines | Small interfering RNA | Antibodies | Immunoblotting | Reports | Viability | Lung neoplasms | Tumors | Apoptosis | TRIAL | GROWTH-FACTOR RECEPTOR | THERAPY | RAS/RAF/MEK/ERK PATHWAY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | CELL-CYCLE PROGRESSION | INHIBITOR | ZD1839 | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Sequence Deletion | Humans | Lung Neoplasms - pathology | Mutation, Missense | DNA-Binding Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Transfection | Milk Proteins | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Cell Survival | Proto-Oncogene Proteins c-akt | Tyrosine - metabolism | Animals | STAT5 Transcription Factor | Cell Line, Tumor | Trans-Activators - metabolism | Mice | RNA, Small Interfering | Carcinoma, Non-Small-Cell Lung - drug therapy | Enzyme Activation | Mutation | Trans-Activators - antagonists & inhibitors | Quinazolines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Protein tyrosine kinase | Physiological aspects | Genetic aspects | Research | Drug therapy | Lung cancer | Enzymes | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2007, Volume 446, Issue 7132, pp. 145 - 146
Cancer results from an accumulation of mutations and other heritable changes in susceptible cells. Studies that have provided the first unbiased, large-scale... 
LUNG-CANCER | GEFITINIB | HUMAN BREAST | MUTATIONS | GENE | MULTIDISCIPLINARY SCIENCES | Protein Kinases - genetics | Neoplasms - genetics | Genomics | Humans | DNA Mutational Analysis - trends | Mutation - genetics | Genes, Neoplasm - genetics | Genome, Human - genetics | Mutation | Cellular biology | Deoxyribonucleic acid | DNA | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18392 - 18397
Journal Article
Cell, ISSN 0092-8674, 07/2016, Volume 166, Issue 3, pp. 740 - 754
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6219, pp. 273 - 277
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination... 
GLIOBLASTOMA | REPEAT-CONTAINING RNA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | POLYMERASE | CHROMOSOME ENDS | SINGLE-STRANDED-DNA | HOMOLOGOUS RECOMBINATION | MUTATIONS | TUMORS | DISCOVERY | Osteosarcoma - drug therapy | Ataxia Telangiectasia Mutated Proteins - metabolism | RNA, Untranslated - metabolism | Humans | Homologous Recombination | X-linked Nuclear Protein | Telomere - drug effects | Sulfones - pharmacology | RNA, Untranslated - genetics | Gene Knockdown Techniques | Glioma - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Telomere - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Telomere Homeostasis | Transcription Factors - metabolism | DNA Helicases - metabolism | Cell Cycle | Cell Line, Tumor | Telomeric Repeat Binding Protein 2 - metabolism | HeLa Cells | Osteosarcoma - genetics | Pyrazines - pharmacology | Glioma - drug therapy | Promyelocytic Leukemia Protein | Apoptosis | Telomeres | Protein research | Cell research | Cancer cells | Cell cycle | Genetic aspects | Research | Health aspects | Enzymes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Proteins | Inhibitors | Deoxyribonucleic acid | Kinases | Chromosomes | Telomerase | Tumors
Journal Article
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6119, pp. 580 - 584
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7579, pp. 452 - 453
Using mouse models of mammary tumours, Fischer and co-workers (page 472) surveyed the fate of epithelial tumour cells transitioning to a mesenchymal state,... 
Studies | Proteins | Transcription factors | Metastasis | Rodents | Tumors
Journal Article