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The Journal of Cell Biology, ISSN 0021-9525, 12/2007, Volume 179, Issue 6, pp. 1311 - 1323
The conjunctive presence of mechanical stress and active transforming growth factor β1 (TGF-β1) is essential to convert fibroblasts into contractile... 
Lungs | Fibrosis | Fibroblasts | Antibodies | Stress fibers | Actins | Cultured cells | Cytoskeleton | Myofibroblasts | Integrins
Journal Article
Journal Article
Science, ISSN 0036-8075, 6/2013, Volume 340, Issue 6139, pp. 1456 - 1459
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 01/2015, Volume 230, Issue 1, p. 226
  Mice deficient in Latent TGF[beta] Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by... 
Journal Article
Journal of Cell Science, ISSN 0021-9533, 01/2003, Volume 116, Issue 2, pp. 217 - 224
TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, 'TGFbeta activators,' release TGFbeta... 
Transforming growth factor-β | Activation | Sensor | DOMAIN-SPECIFIC MUTATIONS | EMBRYO FIBROBLASTS | CELL BIOLOGY | transforming growth factor-beta | BINDING-PROTEIN LTBP-1 | GROWTH-FACTOR-BETA | MESSENGER-RNA | 8-CYSTEINE REPEAT | CAMURATI-ENGELMANN-DISEASE | TRANSFORMING GROWTH-FACTOR-BETA-1 | sensor | EXTRACELLULAR-MATRIX | activation | SMOOTH-MUSCLE CELLS
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2004, Volume 165, Issue 5, pp. 723 - 734
Transforming growth factor-βs (TGF-β) are secreted as inactive complexes containing the TGF-β, the TGF-β propeptide, also called the latency-associated protein... 
Polymerase chain reaction | Cell growth | Complementary DNA | Carrier proteins | Cell lines | Amino acids | Mathematical functions | CHO cells | Cells | Integrins | Latent TGF-β | TGF-β | Integrin | LTBP | LTBP; TGF-β; integrin; αvβ6; latent TGF-β
Journal Article
Science, ISSN 0036-8075, 4/2006, Volume 312, Issue 5770, pp. 117 - 121
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected... 
Airspace | Receptors | Architecture | Dilatation | Root growth | Placebos | Reports | Mice | Aortic aneurysm | Elastic tissue | Marfan syndrome | PATHOGENESIS | GROWTH-FACTOR-BETA | ACTIVATION | FIBRILLIN | MULTIDISCIPLINARY SCIENCES | RATS | RECEPTOR | SMOOTH-MUSCLE-CELLS | BLOCKADE | CONTRIBUTES | DILATATION | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Propranolol - therapeutic use | Neutralization Tests | Aortic Aneurysm - etiology | Lung Diseases - drug therapy | Marfan Syndrome - drug therapy | Propranolol - administration & dosage | Antibodies - immunology | Transforming Growth Factor beta - antagonists & inhibitors | Female | Marfan Syndrome - complications | Microfilament Proteins - genetics | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - therapeutic use | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Fibrillin-1 | Lung - pathology | Pulmonary Alveoli - pathology | Signal Transduction | Fibrillins | Pregnancy Complications - drug therapy | Aorta - pathology | Pregnancy | Elastic Tissue - pathology | Animals | Receptor, Angiotensin, Type 1 - metabolism | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Losartan - administration & dosage | Lung Diseases - pathology | Mutation | Transforming Growth Factor beta - metabolism | Complications and side effects | Aortic aneurysms | Genetic aspects | Research | Risk factors
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29862
Background: Breast to bone metastases frequently induce a "vicious cycle'' in which osteoclast mediated bone resorption and proteolysis results in the release... 
BREAST-CANCER | GROWTH-FACTOR-BETA | METASTASIS | GELATINASE-A | METALLOPROTEINASE | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | LATENT | BINDING-PROTEIN | MATRIX-METALLOPROTEINASE-9 | EXTRACELLULAR-MATRIX | Neoplasms - metabolism | Bone and Bones - pathology | Bone Neoplasms - secondary | Cell Survival - genetics | Cercopithecus aethiops | Matrix Metalloproteinase 2 - physiology | X-Ray Microtomography | Bone Neoplasms - metabolism | Neoplasms - genetics | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Female | Bone Neoplasms - genetics | Osteoblasts - enzymology | Bone Neoplasms - diagnostic imaging | Matrix Metalloproteinase 2 - metabolism | Cells, Cultured | Transforming Growth Factor beta - physiology | Neoplasms - diagnostic imaging | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Animals | Models, Biological | Mice | Cellular Microenvironment - genetics | Neoplasms - pathology | Osteoblasts - metabolism | COS Cells | Transforming Growth Factor beta - metabolism | Proteases | Proteolysis | Analysis | Bone morphogenetic proteins | Metastasis | Transforming growth factors | Enzyme-linked immunosorbent assay | Cancer | Dentin | Immunohistochemistry | Animal models | Intercellular signalling | Matrix metalloproteinases | Proteinase | Transforming growth factor-b | Biology | Arthritis | Cell interactions | Assaying | Caspase-3 | Osteoblasts | Metastases | Bone resorption | Bone histomorphometry | Cell activation | Biomedical materials | Biocompatibility | Extracellular matrix | Longitudinal studies | Localization | Bone matrix | Growth factors | CD11b antigen | Cell survival | Agar | Caspase | Cultures | Breast cancer | Bioavailability | Survival | Gelatinase A | Osteoclastogenesis | Bone cancer | Osteoblastogenesis | Correlation analysis | Bone | Mutation | Apoptosis
Journal Article