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Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 03/2019, Volume 47, Issue 3, pp. 257 - 268
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts | Index Medicus
Journal Article
Science, ISSN 0036-8075, 06/2010, Volume 328, Issue 5983, pp. 1251 - 1255
Journal Article
by Loch, Jennifer A and Li, Heng and Walter, Klaudia and Liao, Arnold K and Chris Pinkard, D and Ivanov, Denis V and O'Neill, Michael J and Aniebo, Ify C and Haudenschild, Christian D and Ewan, Mark R and Earnshaw, David J and Ernest Sohna Sohna, Jean and Spence, Eric J and Worsley, Graham J and Goddard, Colin P and Bailey, David M. D and Ling Ng, Bee and Moon, Keith W and Carter, Richard J and Khrebtukova, Irina and Mullikin, James C and Parkinson, Michael L and Banerjee, Saibal and Harnish, Kevin and Sizto, Ning L and Etchin, Sergey S and Smith, Mark E and Shaw, Richard J and Novo, Sonia M and Ning, Zemin and Diakoumakos, Konstantinos D and Alam, Mohammed D and Bridgham, John A and Sluis, Johannes P and Mammen, Radhika M and Lok, Mitch and Egbujor, Ugonna C and Pickering, Lea and Scott Furey, W and Kumar, Anil and Mehta, Parul and Barbour, Selena G and Brown, Clive G and Rae, Vicki H and Luo, Shujun and Zuerlein, Mike and Torrance, Peta E and Hoschler, Katya and Rogers, Jane and Smith, Vincent P and Elmore, David W and Ostadan, Omead and Sabot, Andrea and Neil Cooley, R and Evers, Dirk J and Fedurco, Milan and Heyer, Narinder I and Karbelashvili, Mirian S and Black, Phillip J and Brown, Andrew A and Romieu, Anthony and Rawlings, Stephen R and Cox, Anthony J and Bignell, Helen R and Castillo, Nestor and Virk, Selene M and McCooke, Nick J and Durbin, Richard and Ellis, Darren J and Pliskin, Daniel P and Ruediger, Silke T and Boutell, Jonathan M and vandeVondele, Stephanie and Schenker, Martin R and Rasolonjatovo, Isabelle M. J and Hims, Matthew M and Benson, Kevin F and Yan, Juying and Seoane, Josefina M and Walcott, Gregory C and Irving, Leslie J and Rogers, John and Granieri, Philip A and Hurwitz, Steve and Milton, John and Smith, Geoffrey P and Rogert Bacigalupo, Maria C and McCauley, Patrick G and Sutton, Neil and Obradovic, Bojan and Tzonev, Svilen S and Stevens, Kim and Buermann, Dale H and Quijano, Victor J and Anastasi, Carole and Rigatti, Roberto and Benoit, Vincent A and Crake, Natasha R and Bundu, Abass A and Scally, Aylwyn and ...
Nature, ISSN 0028-0836, 11/2008, Volume 456, Issue 7218, pp. 53 - 59
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 3, pp. 1070 - 1075
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2011, Volume 67, Issue 2, pp. 349 - 360
Journal Article