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1. Full Text Closed-loop artificial pancreas systems: Engineering the algorithms
by Doyle III, Francis J and Huyett, Lauren M and Lee, Joon Bok and Zisser, Howard C and Dassau, Eyal
Diabetes Care, ISSN 0149-5992, 2014, Volume 37, Issue 5, pp. 1191 - 1197
In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical aspects of artificial pancreas (AP) development are described.... 
YOUNG-ADULTS | CONTROLLED-TRIAL | GLUCOSE CONTROL | FEASIBILITY | ADOLESCENTS | ENDOCRINOLOGY & METABOLISM | HYPOGLYCEMIA | GLUCAGON DELIVERY | INSULIN DELIVERY-SYSTEM | CLINICAL-EXPERIENCE | Humans | Middle Aged | Pancreas, Artificial - trends | Child, Preschool | Insulin - administration & dosage | Biomedical Engineering - instrumentation | Diabetes Mellitus, Type 1 - therapy | Biomedical Engineering - trends | Insulin Infusion Systems - trends | Young Adult | Algorithms | Outpatients | Diabetes Mellitus, Type 1 - blood | Adolescent | Adult | Biomedical Engineering - methods | Blood Glucose - metabolism | Child | Insulin - therapeutic use | Physiological aspects | Care and treatment | Research | Type 1 diabetes | Series & special reports | Comparative studies | Physiology | Diabetes | Pancreas | Insulin | Index Medicus | Advances in Artificial Pancreas Development
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2. Full Text Event-Triggered Model Predictive Control for Embedded Artificial Pancreas Systems
by Chakrabarty, Ankush and Zavitsanou, Stamatina and Doyle, Francis J and Dassau, Eyal
IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, 03/2018, Volume 65, Issue 3, pp. 575 - 586
Objective: The development of artificial pancreas (AP) technology for deployment in low-energy, embedded devices is contingent upon selecting an efficient... 
Algorithm design and analysis | Artificial pancreas | model predictive control | type 1 diabetes | embedded systems | Predictive models | Prediction algorithms | event-triggering | Safety | Pancreas | Insulin | Sugar | MPC | SAFETY | ENGINEERING, BIOMEDICAL | BLOOD-GLUCOSE | HOME-USE | INSULIN DELIVERY | AUTOMATED GLUCOSE CONTROL | CLOSED-LOOP CONTROL | HYPOGLYCEMIA | TYPE-1 | RANDOMIZED CROSSOVER TRIAL | Hypoglycemia - prevention & control | Hypoglycemic Agents - therapeutic use | Algorithms | Hypoglycemic Agents - administration & dosage | Humans | Blood Glucose Self-Monitoring | Models, Statistical | Hypoglycemia - drug therapy | Diabetes Mellitus, Type 1 - drug therapy | Pancreas, Artificial | Energy consumption | Electronic devices | Computer simulation | Decision making | Diabetes mellitus | Control systems | Diabetes mellitus (insulin dependent) | Glucose | Hypoglycemia | Closed loops | Embedded systems | Control | Microprocessors | Energy | Safety engineering | Control algorithms | Design specifications | Mathematical models | Control theory | Meals | Predictive control | Index Medicus | Event-triggering | artificial pancreas
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3. Full Text Adaptive Zone Model Predictive Control of Artificial Pancreas Based on Glucose- and Velocity-Dependent Control Penalties
by Shi, Dawei and Dassau, Eyal and Doyle, Francis J
IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, 04/2019, Volume 66, Issue 4, pp. 1045 - 1054
Objective: Zone model predictive control (MPC) has been proven to be an efficient approach to closed-loop insulin delivery in clinical studies. In this paper,... 
Artificial pancreas | model predictive control | Adaptation models | safety-critical control | Predictive models | Cost function | adaptive controller tuning | Insulin | Sugar | Blood | Predictive control | MPC | INSULIN DELIVERY | SAFETY | ENGINEERING, BIOMEDICAL | STRATEGY | CLINICAL-TRIALS | SYSTEMS | SETTINGS | Statistical analysis | Computer simulation | Fines & penalties | Feasibility studies | Glucose | Hypoglycemia | Adaptive control | Velocity | Mathematical models | Pancreas | Meals | Adaptation
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4. Full Text Multiple order model migration and optimal model selection for online glucose prediction in Type 1 diabetes
by Zhao, Hong and Zhao, Chunhui and Yu, Chengxia and Dassau, Eyal
AIChE Journal, ISSN 0001-1541, 03/2018, Volume 64, Issue 3, pp. 822 - 834
To address the problem of insufficient available modeling data for glucose prediction, as well as modeling burden, a model migration method was developed in a... 
glucose prediction | particle swarm optimization (PSO) | hyper/hypoglycaemia alert | multiple order model migration (MOMM) | optimal model selection | ARTIFICIAL PANCREAS | ALGORITHM | MEAL | hyper hypoglycaemia alert | TIME | IDENTIFICATION | ENGINEERING, CHEMICAL | NEURAL-NETWORKS | THERAPY | MONITORING SENSORS | TECHNOLOGY | Algorithms | Type 1 diabetes | Analysis | Models | Glucose | Mathematical optimization | Dextrose | Migration | Diabetes mellitus | Swarm intelligence | Order parameters | Diabetes mellitus (insulin dependent) | Modelling | Mathematical models | Diabetes | Insulin | Optimization
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5. Full Text Fully integrated artificial pancreas in type 1 diabetes: Modular closed-loop glucose control maintains near normoglycemia
by Breton, Marc and Farret, Anne and Bruttomesso, Daniela and Anderson, Stacey and Magni, Lalo and Patek, Stephen and Man, Chiara Dalla and Place, Jerome and Demartini, Susan and Del Favero, Simone and Toffanin, Chiara and Hughes-Karvetski, Colleen and Dassau, Eyal and Zisser, Howard and Doyle III, Francis J and De Nicolao, Giuseppe and Avogaro, Angelo and Cobelli, Claudio and Renard, Eric and Kovatchev, Boris and Int Artificial Pancreas iAP Study and International Artificial Pancreas Study Group and on behalf of The International Artificial Pancreas (iAP) Study Group
Diabetes, ISSN 0012-1797, 09/2012, Volume 61, Issue 9, pp. 2230 - 2237
Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with insulin pump (continuous subcutaneous insulin infusion [CSII]), known... 
SYSTEM | ADULTS | INFUSION | INSULIN DELIVERY | MODEL | ENDOCRINOLOGY & METABOLISM | Hypoglycemic Agents - therapeutic use | Automation | Humans | Middle Aged | Diabetes Mellitus, Type 1 - drug therapy | Cross-Over Studies | Algorithms | Computer Simulation | Diabetes Mellitus, Type 1 - blood | Adolescent | Adult | Insulin Infusion Systems | Blood Glucose - metabolism | Pancreas, Artificial | Artificial organs | Care and treatment | Usage | Research | Type 1 diabetes | Methods | Index Medicus | Abridged Index Medicus | Methodology Review
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6. Full Text Predictive Low-Glucose Suspend to Prevent Hypoglycemia
by Pinsker, Jordan E and Dassau, Eyal
Diabetes Technology & Therapeutics, ISSN 1520-9156, 05/2017, Volume 19, Issue 5, pp. 271 - 276
Commentaries | Low glucose suspend | AUTOMATED INSULIN SUSPENSION | NOCTURNAL HYPOGLYCEMIA | MANAGEMENT-SYSTEM | ALGORITHM | Automated insulin delivery | Hypoglycemia | EXERCISE | CHILDREN | Artificial pancreas | Predictive low glucose suspend | REDUCTION | Type 1 diabetes | ADOLESCENTS | ENDOCRINOLOGY & METABOLISM | PUMP THERAPY | TYPE-1 | Insulin Infusion Systems | Glucose | Humans | Diabetes
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7. Full Text Closed-Loop Control of Artificial Pancreatic \beta -Cell in Type 1 Diabetes Mellitus Using Model Predictive Iterative Learning Control
by Youqing Wang and Dassau, E and Doyle, F.J
IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, 02/2010, Volume 57, Issue 2, pp. 211 - 219
A novel combination of iterative learning control (ILC) and model predictive control (MPC), referred to here as model predictive iterative learning control... 
Glycemic control | model predictive control | type 1 diabetes mellitus | Predictive models | Blood | Robust control | iterative learning control | run-to-run control | Automatic control | Iterative algorithms | Diabetes | Pancreas | Sugar | Monitoring | Predictive control | TO-RUN CONTROL | ENGINEERING, BIOMEDICAL | GLUCOSE | Systems Biology - methods | Algorithms | Models, Biological | Artificial Intelligence | Computer Simulation | Diabetes Mellitus, Type 1 - blood | Humans | Insulin - administration & dosage | Insulin Infusion Systems | Blood Glucose - metabolism | Insulin - blood | Diabetes Mellitus, Type 1 - drug therapy | Care and treatment | Usage | Feedback control systems | Iterative methods (Mathematics) | Index Medicus
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8. Full Text Randomized crossover comparison of personalized MPC and PID control algorithms for the artificial pancreas
by Pinsker, Jordan E and Lee, Joon Bok and Dassau, Eyal and Seborg, Dale E and Bradley, Paige K and Gondhalekar, Ravi and Bevier, Wendy C and Huyett, Lauren and Zisser, Howard C and Doyle, Francis J
Diabetes Care, ISSN 0149-5992, 07/2016, Volume 39, Issue 7, pp. 1135 - 1142
OBJECTIVE To evaluate two widely used control algorithms for an artificial pancreas (AP) under nonideal but comparable clinical conditions. RESEARCH DESIGN AND... 
TRIAL | SYSTEM | GLYCEMIC CONTROL | GLUCOSE CONTROL | CLOSED-LOOP CONTROL | SAFETY | CLINICAL-EVALUATION | MEAL | ENDOCRINOLOGY & METABOLISM | TYPE-1 | Pancreas, Artificial - adverse effects | Humans | Middle Aged | Insulin - administration & dosage | Male | Diabetes Mellitus, Type 1 - therapy | Feasibility Studies | Blood Glucose - drug effects | Cross-Over Studies | Hypoglycemia - prevention & control | Young Adult | Pilot Projects | Algorithms | Hypoglycemic Agents - administration & dosage | Diabetes Mellitus, Type 1 - blood | Adult | Female | Insulin Infusion Systems | Aged | Blood Glucose - metabolism | Meals | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Precision Medicine - methods | Clinical trials | Usage | Care and treatment | Type 1 diabetes | Control algorithms | Diabetes | Glucose | Pancreas | Clinical outcomes | Predictive control | Index Medicus | The Artificial Pancreas in 2016 | A Digital Treatment Ecosystem for Diabetes
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9. Full Text Extremum Seeking Control for Personalized Zone Adaptation in Model Predictive Control for Type 1 Diabetes
by Cao, Zhixing and Gondhalekar, Ravi and Dassau, Eyal and Doyle, Francis J
IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, 08/2018, Volume 65, Issue 8, pp. 1859 - 1870
Zone model predictive control has proven to be an effective closed-loop method to regulate blood glucose for people with type 1 diabetes (T1D). In this paper,... 
personalization | type 1 diabetes | zone model predictive control | Biomedical measurement | zone adaptation | Robustness | Indexes | Insulin | Sugar | Blood | Extremum seeking control | ARTIFICIAL PANCREAS | TO-RUN CONTROL | ENGINEERING, BIOMEDICAL | STABILITY | SETTINGS | VARIABILITY | TRIAL | SYSTEMS | OPTIMIZATION | FEEDBACK | Blood Glucose Self-Monitoring - methods | Blood Glucose - analysis | Computer Simulation | Diabetes Mellitus, Type 1 - blood | Humans | Diabetes Mellitus, Type 1 - metabolism | Signal Processing, Computer-Assisted | Insulin - administration & dosage | Insulin Infusion Systems | Blood Glucose - metabolism | Insulin - therapeutic use | Diabetes Mellitus, Type 1 - drug therapy | Medical research | Uncertainty | Diabetes mellitus | Clinical trials | Diabetes mellitus (insulin dependent) | Glucose | Optimization | Lower bounds | Upper bounds | Mathematical models | Diabetes | Meals | Adaptation | Predictive control
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10. Full Text Safety of outpatient closed-loop control: First randomized crossover trials of a wearable artificial pancreas
by Kovatchev, Boris P and Kovatchev, Boris P and Renard, Eric and Cobelli, Claudio and Zisser, Howard C and Keith-Hynes, Patrick and Anderson, Stacey M and Brown, Sue A and Chernavvsky, Daniel R and Breton, Marc D and Mize, Lloyd B and Farret, Anne and Place, Jérôme and Bruttomesso, Daniela and Del Favero, Simone and Boscari, Federico and Galasso, Silvia and Avogaro, Angelo and Magni, Lalo and Di Palma, Federico and Toffanin, Chiara and Messori, Mirko and Dassau, Eyal and Doyle III, Francis J
Diabetes Care, ISSN 0149-5992, 07/2014, Volume 37, Issue 7, pp. 1789 - 1796
OBJECTIVE We estimate the effect size of hypoglycemia risk reduction on closed-loop control (CLC) versus open-loop (OL) sensor-augmented insulin pump therapy... 
SYSTEM | ADULTS | MPC | INSULIN DELIVERY | GLUCOSE CONTROL | ENDOCRINOLOGY & METABOLISM | Hypoglycemic Agents - therapeutic use | Pancreas, Artificial - adverse effects | Humans | Middle Aged | Insulin - administration & dosage | Male | Treatment Outcome | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Cross-Over Studies | Outpatients | Hypoglycemic Agents - administration & dosage | Diabetes Mellitus, Type 1 - blood | Blood Glucose Self-Monitoring | Adult | Female | Insulin Infusion Systems | Cell Phone | Hypoglycemia - chemically induced | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Insulin - therapeutic use | Usage | Care and treatment | Safety and security measures | Insulin pumps | Clinical trials | Research | Hypoglycemia | Carbohydrates | Diabetes | Insulin | Risk assessment | Medical treatment | Index Medicus | Diabetes Care Symposium
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11. Full Text Clinical evaluation of a personalized artificial pancreas
by Dassau, Eyal and Zisser, Howard and Harvey, Rebecca A and Percival, Matthew W and Grosman, Benyamin and Bevier, Wendy and Atlas, Eran and Miller, Shahar and Nimri, Revital and Jovanovič, Lois and Doyle III, Francis J
Diabetes Care, ISSN 0149-5992, 04/2013, Volume 36, Issue 4, pp. 801 - 809
OBJECTIVE-An artificial pancreas (AP) that automatically regulates blood glucose would greatly improve the lives of individuals with diabetes. Such a device... 
SYSTEM | MPC | ALGORITHM | ENDOCRINOLOGY & METABOLISM | ADULTS | HYPOGLYCEMIA | LOOP INSULIN DELIVERY | BLOOD-GLUCOSE CONTROL | Blood Glucose | Insulin Infusion Systems | Algorithms | Humans | Diabetes Mellitus, Type 1 - drug therapy | Pancreas, Artificial | Complications and side effects | Care and treatment | Type 1 diabetes | Patient outcomes | Artificial organs | Dosage and administration | Research | Health aspects | Insulin | Automation | Diabetes | Glucose | Meals | Index Medicus | Original Research
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12. Full Text Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension
by Buckingham, Bruce and Chase, H. Peter and Dassau, Eyal and Cobry, Erin and Clinton, Paula and Gage, Victoria and Caswell, Kimberly and Wilkinson, John and Cameron, Fraser and Lee, Hyunjin and Bequette, B. Wayne and Doyle III, Francis J
Diabetes Care, ISSN 0149-5992, 05/2010, Volume 33, Issue 5, pp. 1013 - 1017
OBJECTIVE - The aim of this study was to develop a partial closed-loop system to safely prevent nocturnal hypoglycemia by suspending insulin delivery when... 
SYSTEM | RESPONSES | METABOLIC DETERIORATION | ADOLESCENTS | PEDIATRIC-PATIENTS | ENDOCRINOLOGY & METABOLISM | INFUSION | TYPE-1 | INTERRUPTION | CHILDREN | Hypoglycemia - diagnosis | Predictive Value of Tests | Humans | Insulin - administration & dosage | Circadian Rhythm - physiology | Clinical Alarms | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Hypoglycemia - prevention & control | Young Adult | Algorithms | Hypoglycemic Agents - administration & dosage | Ketones - blood | Adolescent | Adult | Insulin Infusion Systems | Blood Glucose - metabolism | Hypoglycemia - chemically induced | Child | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Research | Type 1 diabetes | Insulin | Diabetes therapy | Studies | Diabetes | Hypoglycemia | Monitoring systems | Index Medicus | Original Research
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13. Full Text Enzymatic/Immunoassay Dual‐Biomarker Sensing Chip: Towards Decentralized Insulin/Glucose Detection
by Vargas, Eva and Teymourian, Hazhir and Tehrani, Farshad and Eksin, Ece and Sánchez‐Tirado, Esther and Warren, Paul and Erdem, Arzum and Dassau, Eyal and Wang, Joseph
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2019, Volume 58, Issue 19, pp. 6376 - 6379
Performing bioassay formats based on enzyme and antibody recognition reactions with a single detection chip remains an unmet challenge owing to the different... 
immunoassays | biosensors | electrochemistry | diabetes monitoring | dual-marker detection | INSULIN | GOLD | SELF-ASSEMBLED MONOLAYERS | ENZYME | REMOVAL | GLUCOSE | CHEMISTRY, MULTIDISCIPLINARY | Oxidases | Antigen-antibody reactions | Viral antibodies | Electrochemical reactions | Detectors | Electrochemistry | Antibodies | Glucose | Dextrose | Electric properties | Glucose oxidase | Immunoassay | Enzymes | Bioassays | Diabetes mellitus | Surface chemistry | Immunosensors | Biological assays | Insulin | Fabrication | Organic chemistry | Biomarkers | Peroxidase | Bioindicators | Biosensors | Saliva
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14. Full Text Switched LPV Glucose Control in Type 1 Diabetes
by Colmegna, Patricio H and Sanchez-Pena, Ricardo S and Gondhalekar, Ravi and Dassau, Eyal and Doyle, Frank J
IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, 06/2016, Volume 63, Issue 6, pp. 1192 - 1200
Objective: The purpose of this paper is to regulate the blood glucose level in Type 1 Diabetes Mellitus patients with a practical and flexible procedure that... 
Artificial pancreas | type 1 diabetes mellitus | Protocols | Switches | switching control | Mathematical model | Insulin | LPV control | Sugar | Blood | Type 1 diabetes mellitus | Artificial pancreas (AP) | TRIAL | INSULIN DELIVERY | ENGINEERING, BIOMEDICAL | type 1 diabetes mellitus (T1DM) | LOOP ARTIFICIAL PANCREAS | MEAL | SYSTEMS | MODEL | Hypoglycemic Agents - therapeutic use | Insulin - pharmacology | Blood Glucose - analysis | Humans | Insulin - administration & dosage | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Algorithms | Hypoglycemic Agents - administration & dosage | Models, Biological | Computer Simulation | Signal Processing, Computer-Assisted | Insulin Infusion Systems | Insulin - therapeutic use | Pancreas, Artificial | Medical equipment | Medical protocols | Usage | Mathematical models | Research | Physiological apparatus | Geriatrics | Glucose | Index Medicus
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15. Full Text Periodic zone-MPC with asymmetric costs for outpatient-ready safety of an artificial pancreas to treat type 1 diabetes
by Gondhalekar, Ravi and Dassau, Eyal and Doyle, Francis J
Automatica, ISSN 0005-1098, 09/2016, Volume 71, pp. 237 - 246
A novel Model Predictive Control (MPC) law for an Artificial Pancreas (AP) to automatically deliver insulin to people with type 1 diabetes is proposed. The MPC... 
Artificial pancreas | Model predictive control | Safety-critical control | Periodic control | Type 1 diabetes mellitus | MODEL-PREDICTIVE CONTROL | ENGINEERING, ELECTRICAL & ELECTRONIC | TRIAL | INSULIN DELIVERY | CLOSED-LOOP CONTROL | SYSTEMS | BLOOD-GLUCOSE CONTROL | AUTOMATION & CONTROL SYSTEMS | Safety and security measures | Glucose | Type 1 diabetes | Drug approval | Analysis | Dextrose | Hyperglycemia
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16. Full Text Multinational home use of closed-loop control is safe and effective
by Anderson, Stacey M and Raghinaru, Dan and Pinsker, Jordan E and Boscari, Federico and Renard, Eric and Buckingham, Bruce A and Nimri, Revital and Doyle, Francis J and Brown, Sue A and Keith-Hynes, Patrick and Breton, Marc D and Chernavvsky, Daniel and Bevier, Wendy C and Bradley, Paige K and Bruttomesso, Daniela and Del Favero, Simone and Calore, Roberta and Cobelli, Claudio and Avogaro, Angelo and Farret, Anne and Place, Jerome and Ly, Trang T and Shanmugham, Satya and Phillip, Moshe and Dassau, Eyal and Dasanayake, Isuru S and Kollman, Craig and Lum, John W and Beck, Roy W and Kovatchev, Boris and Control Range Study Grp and Control to Range Study Group
Diabetes Care, ISSN 0149-5992, 07/2016, Volume 39, Issue 7, pp. 1143 - 1150
OBJECTIVE To evaluate the efficacy of a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs] running the Unified Safety... 
CONTROL 1ST | MANAGEMENT | INSULIN PUMP THERAPY | ADOLESCENTS | ENDOCRINOLOGY & METABOLISM | OPEN-LABEL | OVERNIGHT GLUCOSE CONTROL | WEARABLE ARTIFICIAL PANCREAS | RANDOMIZED CROSSOVER TRIAL | DELIVERY | CHILDREN | Blood Glucose - analysis | Pancreas, Artificial - adverse effects | Humans | Middle Aged | Insulin - administration & dosage | Male | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Hypoglycemia - prevention & control | Young Adult | Blood Glucose Self-Monitoring - methods | Hypoglycemic Agents - administration & dosage | Mobile Applications | Internationality | Diabetes Mellitus, Type 1 - blood | Adolescent | Adult | Female | Insulin Infusion Systems | Aged | Blood Glucose Self-Monitoring - instrumentation | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Smartphone | Care and treatment | Glycemic index | Hypoglycemia | Type 1 diabetes | Analysis | Risk factors | Wearable computers | Clinical trials | Glucose | Diabetes | Closed loop systems | Pancreas | Biosensors | Index Medicus | Life Sciences | Human health and pathology | Endocrinology and metabolism | The Artificial Pancreas in 2016 | A Digital Treatment Ecosystem for Diabetes
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