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Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 5523 - 5523
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 570 - 575
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2006, Volume 281, Issue 7, pp. 4334 - 4338
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 3846 - 3846
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. E1288 - E1296
BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in... 
Targeted therapies | Small-cell lung cancer | BH3 mimetics | BIM | Apoptosis | DRUG-SENSITIVITY | small-cell lung cancer | targeted therapies | ANTAGONIST ABT-737 | MCL-1 | MULTIDISCIPLINARY SCIENCES | apoptosis | KINASE INHIBITORS | OBATOCLAX GX15-070 | CAP-DEPENDENT TRANSLATION | BCL-2 FAMILY INHIBITOR | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHASE-I | Lung Neoplasms - drug therapy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Lung Neoplasms - pathology | Mechanistic Target of Rapamycin Complex 2 | Small Cell Lung Carcinoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Bcl-2-Like Protein 11 | Inhibitory Concentration 50 | Membrane Proteins - metabolism | Morpholines - therapeutic use | Proto-Oncogene Proteins - metabolism | Aniline Compounds - pharmacology | Morpholines - pharmacology | Sulfonamides - pharmacology | Remission Induction | Apoptosis Regulatory Proteins - metabolism | Xenograft Model Antitumor Assays | Small Cell Lung Carcinoma - pathology | Animals | Genetic Engineering | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Mice | Aniline Compounds - therapeutic use | Antimitotic agents | Molecular targeted therapy | Care and treatment | Lung cancer, Small cell | Genetic aspects | Antineoplastic agents | Methods | Testing | Biological Sciences | PNAS Plus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. A77 - A77
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2015, Volume 21, Issue 4 Supplement, pp. A27 - A27
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4648 - 4648
Therapeutic options for triple negative breast cancers (TNBC) are limited to multiple lines of chemotherapy with no FDA-approved targeted therapies. In the... 
Journal Article
Cell Reports, ISSN 2211-1247, 12/2017, Volume 21, Issue 11, pp. 3298 - 3309
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2933 - 2933
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 5213 - 5213
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 1, pp. 312 - 324
Purpose: Effective targeted therapies are lacking for refractory and relapsed T-cell acute lymphoblastic leukemia (T-ALL). Suppression of the NOTCH pathway... 
TARGET | BCL-2 | LYMPHOMA-CELLS | INHIBITION | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | MTOR PATHWAY | SENSITIVITY | BH3 MIMETIC ABT-737 | ACTIVATING MUTATIONS | TRANSLATIONAL CONTROL | leukemia | targeted therapy | NOTCH1 | MCL-1 | mTOR | GSI | ABT-263
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 01/2014, Volume 4, Issue 1, pp. 42 - 52
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2015, Volume 112, Issue 11, p. E1288
  BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in... 
Side effects | Lung cancer | Gene expression | Cancer therapies | Apoptosis | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2006, Volume 281, Issue 7, pp. 4334 - 4338
ISG15 is an interferon (IFN)- alpha / beta -induced ubiquitin-like protein that is conjugated to cellular proteins during innate immune responses to viral and... 
Journal Article