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index medicus (13) 13
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humans (11) 11
liver cancer (9) 9
mice (9) 9
cell biology (8) 8
human necessities (8) 8
hygiene (8) 8
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liver neoplasms - metabolism (6) 6
analysis (4) 4
carcinoma, hepatocellular - genetics (4) 4
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expression (4) 4
hepatocellular-carcinoma (4) 4
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health aspects (3) 3
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hepatocytes - cytology (3) 3
liver (3) 3
liver - metabolism (3) 3
liver neoplasms - pathology (3) 3
medicine, research & experimental (3) 3
mice, inbred c57bl (3) 3
mouse (3) 3
protein kinase inhibitors - pharmacology (3) 3
proteins (3) 3
proteomics (3) 3
research (3) 3
signal transduction (3) 3
abridged index medicus (2) 2
activation (2) 2
apoptosis - genetics (2) 2
article (2) 2
biochemistry, genetics and molecular biology (2) 2
cell cycle checkpoints (2) 2
cell line, tumor (2) 2
cells (2) 2
colletotrichum coccodes (2) 2
cycle (2) 2
digestive system diseases (2) 2
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drug therapy (2) 2
enzymes (2) 2
gene expression (2) 2
gene expression regulation, neoplastic (2) 2
gene knockdown techniques (2) 2
genes (2) 2
genetic aspects (2) 2
hematopoietic stem cells (2) 2
hepatocytes - metabolism (2) 2
hepatocytes - pathology (2) 2
identification (2) 2
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in-vivo (2) 2
insulin (2) 2
kinases (2) 2
kinetics (2) 2
liver - cytology (2) 2
liver - pathology (2) 2
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liver neoplasms, experimental - drug therapy (2) 2
liver neoplasms, experimental - genetics (2) 2
liver neoplasms, experimental - metabolism (2) 2
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mitogen-activated protein kinase 14 - antagonists & inhibitors (2) 2
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niacinamide - analogs & derivatives (2) 2
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Nature, ISSN 0028-0836, 11/2011, Volume 479, Issue 7374, pp. 547 - 551
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2014, Volume 20, Issue 10, pp. 1138 - 1146
In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs or molecularly targeted therapies. Here, we describe a system... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | INTEGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | SENSITIVITY | KINASE INHIBITORS | MAP KINASES | JAK/STAT | STRATEGIES | CELL BIOLOGY | Niacinamide - analogs & derivatives | RNA, Small Interfering - genetics | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Male | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Carcinoma, Hepatocellular - genetics | Female | Antineoplastic Agents - pharmacology | Liver Neoplasms, Experimental - genetics | Liver Neoplasms - genetics | Signal Transduction | Mice, Inbred C57BL | Liver Neoplasms - drug therapy | Mitogen-Activated Protein Kinase 14 - genetics | Activating Transcription Factor 2 - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Liver Neoplasms, Experimental - drug therapy | Liver Neoplasms - metabolism | Mice | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Carcinoma, Hepatocellular - metabolism | Liver cancer | Research | Drug therapy | Drug resistance | Analysis | Biomarkers | Signal transduction | Protein expression | Pharmacology | Ribonucleic acid--RNA
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 744 - 753
MYC oncoproteins are involved in the genesis and maintenance of the majority of human tumors but are considered undruggable. By using a direct in vivo shRNA... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | NEUROENDOCRINE PROSTATE-CANCER | TUMOR SUPPRESSION | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | INHIBITION PROFILE | C-MYC | IDENTIFICATION | CELL BIOLOGY | N-MYC | HUMAN HEPATOCELLULAR-CARCINOMA | Humans | Hepatocytes - metabolism | Aurora Kinase A - antagonists & inhibitors | Molecular Targeted Therapy | Aurora Kinase A - metabolism | Oncogene Protein p21(ras) - metabolism | Tumor Suppressor Protein p53 - genetics | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | Gene Deletion | Liver Neoplasms, Experimental - genetics | Liver Neoplasms - genetics | Liver Neoplasms - drug therapy | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Monomeric GTP-Binding Proteins - genetics | Pyrimidines - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Azepines - pharmacology | Xenograft Model Antitumor Assays | Cell Cycle Checkpoints | Animals | Liver Neoplasms, Experimental - drug therapy | Liver Neoplasms - metabolism | Mice | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Mutation | Carcinoma, Hepatocellular - metabolism | Liver cancer | Care and treatment | Tumor suppressor genes | Development and progression | Genetic aspects | Properties | Gene expression | Phosphotransferases | Health aspects | Proteins | Kinases | Drug therapy
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 05/2019, Volume 10, Issue 1, pp. 2147 - 13
Journal Article
Angewandte Chemie, ISSN 1433-7851, 05/2017, Volume 56, Issue 19, p. 5363
  Skepinone-L was recently reported to be a p38[alpha] MAP kinase inhibitor with high potency and excellent selectivity invitro and invivo. However, this class... 
Enzymes
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2017, Volume 56, Issue 19, p. 5363
Skepinone-L was recently reported to be a p38[alpha] MAP kinase inhibitor with high potency and excellent selectivity in vitro and in vivo. However, this class... 
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2019, Volume 25, Issue 4, pp. 641 - 655
Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLYCOPROTEIN-VI | IN-VIVO DEPLETION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAUSES NONALCOHOLIC STEATOHEPATITIS | ANTIPLATELET THERAPY | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | FACTOR BINDING | SET ENRICHMENT ANALYSIS | INFLAMMATION | MOUSE MODEL | NF-KAPPA-B | Liver - pathology | Humans | Body Weight - drug effects | Hepatocytes - pathology | Liver Neoplasms - blood | Non-alcoholic Fatty Liver Disease - blood | Platelet Glycoprotein GPIb-IX Complex - metabolism | Liver - drug effects | Cytoplasmic Granules - metabolism | Hyaluronan Receptors - metabolism | Platelet Aggregation Inhibitors - pharmacology | Kupffer Cells - metabolism | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Hepatocytes - drug effects | Cytokines - metabolism | Cytoplasmic Granules - drug effects | Liver - metabolism | Liver Neoplasms - drug therapy | Mice, Transgenic | Kupffer Cells - drug effects | Non-alcoholic Fatty Liver Disease - drug therapy | Endothelium - drug effects | Animals | Platelet Count | Endothelium - metabolism | Blood Platelets - metabolism | Hyaluronic Acid - metabolism | Liver | Trafficking | Kupffer cells | Hepatocellular carcinoma | Activation | Agglomeration | Liver cancer | Hyaluronan | Fatty liver | Mac1 protein | CD44 antigen | Sulindac | Nonsteroidal anti-inflammatory drugs | Immune system | Aspirin | Liver diseases | Platelet aggregation | Inflammation | Insulin | Steatosis | Cirrhosis | Microscopy | Clopidogrel | Platelets | Colonization | P-selectin | Cancer
Journal Article
Gastroenterology, ISSN 0016-5085, 2016, Volume 151, Issue 6, pp. 1192 - 1205
Background & Aims Effective treatments are urgently needed for hepatocellular carcinoma (HCC), which is usually diagnosed at advanced stages. Signaling via the... 
Gastroenterology and Hepatology | Therapeutic Target | Hepatocarcinogenesis | Epi-Driver | IGF 1 Receptor | DNA METHYLATION | II GENE | CLASSIFICATION | LIVER-CANCER | INSULIN | GROWTH-FACTOR RECEPTOR | IN-VIVO | THERAPEUTIC TARGETS | PROMOTER | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Niacinamide - analogs & derivatives | Up-Regulation | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Male | Antineoplastic Agents - therapeutic use | RNA, Messenger - metabolism | Case-Control Studies | Proto-Oncogene Proteins c-akt - genetics | Gene Knockdown Techniques | DNA Methylation | Carcinoma, Hepatocellular - drug therapy | Insulin-Like Growth Factor II - genetics | Antibodies, Neutralizing - therapeutic use | Carcinoma, Hepatocellular - genetics | Female | Liver Neoplasms - pathology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Tumor Stem Cell Assay | Gene Expression | Liver Neoplasms - genetics | Mice, Inbred C57BL | Liver Neoplasms - drug therapy | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Antibodies, Neutralizing - pharmacology | Signal Transduction - genetics | Proto-Oncogene Proteins c-myc - metabolism | Insulin-Like Growth Factor II - metabolism | Animals | Neovascularization, Pathologic - drug therapy | Receptors, Somatomedin - metabolism | Sorafenib | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | RNA, Small Interfering | Apoptosis | Carcinoma, Hepatocellular - metabolism | Cell Movement | Liver cancer | Epigenetic inheritance | Medical colleges | Genetic aspects | Liver | Cancer
Journal Article