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2012, Progress in molecular biology and translational science, ISBN 9780123858832, Volume 107., xiv, 467
Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning.... 
Nervous system | Degeneration | Molecular biology | Molecular aspects | Diseases | Clinical & internal medicine
Book
12/2018, Progress in Molecular Biology and Translational Science, ISBN 0128162376, Volume 160., 173
'Progress in Molecular Biology and Translational Science' provides in-depth reviews on topics of exceptional scientific importance. Each volume is edited by an... 
Molecular biology | Nucleic acids
eBook
by Teplow and David B
2019, ISBN 0128165758, 354
eBook
by Teplow and David B
2018, Progress in Molecular Biology and Translational Science, ISBN 9780128162354, Volume 159, 220
'Progress in Molecular Biology and Translational Science' provides in-depth reviews on topics of exceptional scientific importance. Each volume is edited by an... 
Molecular biology | Nucleic acids
eBook
Journal of Neurochemistry, ISSN 0022-3042, 01/2017, Volume 140, Issue 2, p. 210
  The neuropathology of Alzheimer's disease (AD) includes amyloid plaque formation by the amyloid [beta]-protein (A[beta]) and intracellular paired helical... 
Oligomers | Development and progression | Alzheimer's disease | Amyloid beta-protein | Protein binding | Proteins | Neurochemistry | Tomography | Alzheimers disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/1998, Volume 95, Issue 21, pp. 12277 - 12282
Fibrillogenesis of the amyloid β -protein (Aβ ) is believed to play a central role in the pathogenesis of Alzheimer's disease. Previous studies of the kinetics... 
Temperature dependence | Nucleation | Light scattering | Entropy | Kinetics | Amyloids | Solar fibrils | Alzheimers disease | Activation energy | Monomers | TRANSITION | IN-VITRO | DOMAIN | MECHANISM | ALZHEIMERS-DISEASE | KINETICS | MULTIDISCIPLINARY SCIENCES | GROWTH | FIBRILLOGENESIS | AGGREGATION | PEPTIDE | Temperature | Scattering, Radiation | Amyloid beta-Peptides - chemistry | Light | Synthesis | Research | Peptides | Alzheimer's disease | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2016, Volume 113, Issue 21, p. 5835
  Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various neurodegenerative diseases. This process involves protein... 
Proteins | Microscopy | Peptides | Neurodegeneration | Kinetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2016, Volume 113, Issue 21, pp. 5835 - 5840
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12433 - 7
Intrinsically disordered protein (IDP) conformers occupy large regions of conformational space and display relatively flat energy surfaces. Amyloid-forming... 
D-AMINO ACIDS | ALPHA-HELIX | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | BETA-PROTEIN | CHEMICAL-SYNTHESIS | RESIDUE | INDUCED FIT | RACEMIZATION | PEPTIDE | TRYPTOPHAN SCANNING MUTAGENESIS | Amino acid sequence | Amyloid | Polarizability | Chirality
Journal Article
Alzheimer's Research and Therapy, ISSN 1758-9193, 11/2013, Volume 5, Issue 6, pp. 60 - 60
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic agents in Alzheimer's disease, has all but supplanted the amyloid... 
WILD-TYPE | ALPHA-HELIX | HUMAN BRAIN | MECHANISM | A-BETA | PLAQUE-FORMATION | PRECURSOR PROTEIN | ION CHANNELS | SYNAPTIC PLASTICITY | NEUROSCIENCES | PEPTIDE | CLINICAL NEUROLOGY
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2005, Volume 299, pp. 153 - 174
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2003, Volume 100, Issue 1, pp. 330 - 335
Amyloid β-protein (Aβ) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Aβ in AD is new... 
Oligomers | Biological Sciences | Size distribution | Filtration | Trimers | Dimers | Amyloids | Solar fibrils | Alzheimers disease | Monomers | Molecular weight
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12434 - 16
Amyloid beta-protein (A beta) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer's disease (AD). We used an unbiased D-amino acid... 
UNITED-STATES | FIBRIL | APP GENE | ALPHA-HELIX | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | PRECURSOR PROTEIN GENE | MUTATION | FAMILIAL ALZHEIMERS-DISEASE | HEREDITARY CEREBRAL-HEMORRHAGE | THIOFLAVIN T | Oligomerization | Neurodegenerative diseases | Protein folding | Amyloid | Secondary structure | Protein structure | Alzheimer's disease | Amino acid substitution
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2001, Volume 276, Issue 37, pp. 35176 - 35184
Assembly of the amyloid beta -protein (A beta) into neurotoxic oligomers and fibrils is a seminal event in Alzheimer's disease. Understanding the earliest... 
FIBRIL FORMATION | ENHANCED PRODUCTION | IN-VITRO | ATOMIC-FORCE MICROSCOPY | CONFORMATIONAL-CHANGES | TRANSTHYRETIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CULTURE | FIBRILLOGENESIS | PEPTIDE | Prealbumin - chemistry | Molecular Weight | Amyloid beta-Peptides - chemistry | Light | Hydrogen-Ion Concentration
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 06/2004, Volume 37, Issue 6, pp. 357 - 364
Amyloidoses comprise a class of diseases characterized pathologically by the presence of deposits of fibrillar, aberrantly folded proteins, known as amyloids.... 
ELUCIDATION | OXIDATIVE STRESS | BETA-FIBRILLOSES | ALZHEIMERS-DISEASE | COMPLEXES | HUMAN-BRAIN | PROTOFIBRILS | MUTATIONS | OLIGOMERIZATION | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | Cross-Linking Reagents | Amyloid - chemistry | Amyloidosis - metabolism | Protein Folding | Photochemistry | Cellular proteins | Amyloid beta-protein | Research
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 1/2017, Volume 140, Issue 2, pp. 210 - 215
The neuropathology of Alzheimer’s disease (AD) includes amyloid plaque formation by the amyloid β-protein (Aβ) and intracellular paired helical filament... 
Amyloid β-protein (Aβ) | protofibrils | positron emission tomography (PET) | oligomers | Pittsburgh Compound-B (PiB)
Journal Article
Science, ISSN 0036-8075, 10/1999, Volume 286, Issue 5440, pp. 735 - 741
Journal Article
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