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Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3215 - 3215
Abstract Despite recent advances, disease progression and treatment resistance in multiple myeloma (MM) remains a significant challenge. Current therapies... 
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A15051 - A15051
IntroductionPrimary aldosteronism (PA) is a major public health concern given its prevalence and associated cardiovascular and renal pathology. Compared to... 
Journal Article
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 01/2014, Volume 306, Issue 2, pp. E150 - E156
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0134927
Nicotinamide adenine dinucleotide (NAD(+)) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular... 
SKELETAL-MUSCLE | HIGH-FAT | LIPOLYSIS | ACETYLATION | MULTIDISCIPLINARY SCIENCES | FLEXIBILITY | DISEASE | NAD(+) | MICE | SIRT1 | INDUCED OBESITY | ADP-ribosyl Cyclase 1 - genetics | Oxidation-Reduction | Mice, Inbred C57BL | ADP-ribosyl Cyclase - metabolism | Male | Muscle, Skeletal - metabolism | Physical Conditioning, Animal - physiology | Diet, Western - adverse effects | Mice, Knockout | Animals | Metabolic Diseases - metabolism | Metabolic Diseases - genetics | ADP-ribosyl Cyclase 1 - metabolism | Mice | Cyclic ADP-Ribose - metabolism | NAD - metabolism | Niacinamide | Purines | Enzymes | Ablation (Surgery) | Biological products | Genetic research | Muscles | Gene expression | NADPH | Oxidative stress | Sucrose | Calcium | Body fat | Disease | Homeostasis | Environmental changes | Intracellular signalling | Biology | Metabolic syndrome | ADP | DNA repair | Flexibility | High fat diet | Chemical reduction | Redox reactions | Ribose | Rodents | CD38 antigen | Animal tissues | Aging | Physiology | Oxidation | Sugars | Calcium homeostasis | Deoxyribonucleic acid--DNA | Obesity | Calcium (intracellular) | Oxidation-reduction potential | Adenine | Ablation | Skeletal muscle | NAD | Energy balance | Nutrition research | Musculoskeletal system | Intolerance | Diet | Nicotinamide adenine dinucleotide | Insulin resistance | Nicotinamide | Diabetes | Cyclic ADP-ribose | Laboratory animals | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Combinatorial Chemistry and High Throughput Screening, ISSN 1386-2073, 03/2005, Volume 8, Issue 2, pp. 161 - 171
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2000, Volume 347, Issue 1, pp. 131 - 138
Tumour necrosis factor alpha convertase (TACE) is a metallo-protease/disintegrin involved in the ectodomain shedding of several proteins, a process thought to... 
Protein ectodomain shedding | ADAM | Metalloproteinases | MDC | CYSTEINE SWITCH | protein ectodomain shedding | PROTEIN | PRECURSOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | metalloproteinases | CLEAVAGE | METALLOPROTEASE-DISINTEGRIN MDC9 | ENZYME | SEQUENCE | CELL-CELL INTERACTIONS | TNF-ALPHA | INHIBITOR
Journal Article
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 07/2019, Volume 10, Issue 7, pp. 1056 - 1060
Excess aldosterone production and signaling are primary contributors to numerous cardiovascular disorders including primary aldosteronism and resistant... 
MONKEY | IN-VIVO ACTIVITY | POTENT | CHEMISTRY, MEDICINAL | CYP11B2 | DISEASE | cytochrome P450 | Aldosterone | CYP11B2 inhibitor | HYPERTENSION | DISCOVERY | CORTISOL
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/1997, Volume 385, Issue 6618, pp. 733 - 736
Journal Article