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Nature Medicine, ISSN 1078-8956, 02/2013, Volume 19, Issue 2, pp. 202 - 208
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8512 - 8517
Antiapoptotic B-cell lymphoma 2 (Bcl-2) family members such as Bcl-2, myeloid cell leukemia 1 (Mcl-1), and B-cell lymphoma-X large (Bcl-xL) are proposed to... 
Myeloid cells | Starvation | Cell death | Cell lines | Fibroblasts | Cultured cells | Gene expression regulation | Viability | Family members | Apoptosis | ABT-737 | LC3B | LC3 | BH3 mimetic | Bim | SURVIVAL | APOPTOSIS | MCL-1 | MULTIDISCIPLINARY SCIENCES | KINASE | CELL-DEATH | CONNECTION | BECLIN-1 | ROLES | BH3-ONLY PROTEINS | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Cell Survival - genetics | Apoptosis - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Autophagy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Phagosomes - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Animals | Autophagy-Related Protein 5 | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Autophagy (Cytology) | Cell research | Oncology, Experimental | Physiological aspects | Lymphomas | Research | B cells | Health aspects | Cancer | Proteins | Experiments | Cells | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 103 - 107
MCL1 is essential for the survival of stem and progenitor cells of multiple lineages, and is unique among pro-survival BCL2 family members in that it is... 
MULTIPLE-MYELOMA | BREAST-CANCER | APOPTOSIS | IN-VITRO | ACTIVATION | UBIQUITIN LIGASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | PROTEINS | BCL-2 FAMILY | EXPRESSION | Neoplasms - metabolism | Prognosis | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Half-Life | Neoplasms - diagnosis | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Ubiquitination | Ultraviolet Rays | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Ubiquitin Thiolesterase - deficiency | Protein Binding - radiation effects | Ubiquitin Thiolesterase - metabolism | Female | Lysine - metabolism | Protein Stability | Polyubiquitin - metabolism | Cell Line | Cell Survival | Docetaxel | Etoposide - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Ubiquitin Thiolesterase - genetics | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Phosphorylation - radiation effects | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Mice | DNA Damage | Neoplasms - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Care and treatment | Multiple myeloma | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Health aspects | Oncogenes | Cancer | Proteins | Lymphomas | Mass spectrometry | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7626, pp. 477 - 482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is... 
MULTIPLE-MYELOMA | SURVIVAL | ANTI-APOPTOTIC MCL-1 | PROTEIN | DEPENDENCY | BCL-XL | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | TUMOR-CELLS | COMBINATION | NAVITOCLAX | Neoplasms - metabolism | Thiophenes - therapeutic use | Leukemia - pathology | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Male | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Thiophenes - administration & dosage | Antineoplastic Agents - administration & dosage | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Lymphoma - metabolism | Lymphoma - drug therapy | Multiple Myeloma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Female | Lymphoma - pathology | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Pyrimidines - administration & dosage | bcl-2-Associated X Protein - metabolism | Leukemia - drug therapy | Models, Molecular | Thiophenes - pharmacology | Pyrimidines - pharmacology | Multiple Myeloma - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Models, Biological | Pyrimidines - therapeutic use | Cell Line, Tumor | Mice | Neoplasms - pathology | Myelocytic leukemia | Physiological aspects | Nonlymphoid leukemia | Metastasis | Observations | Health aspects | Apoptosis | Proteins | Studies | Multiple myeloma | Cytotoxicity | Kinases | Drug dosages | Tumors | Cancer | Crystal structure | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7258, pp. 1035 - 1039
Journal Article
Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis | Biochemistry | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
PLoS Medicine, ISSN 1549-1277, 10/2007, Volume 4, Issue 10, pp. 1681 - 1690
Background The epidermal growth factor receptor (EGFR) plays a critical role in the control of cellular proliferation, differentiation, and survival.... 
BCL-2 RELATIVE BIM | PATHWAYS | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | MEDICINE, GENERAL & INTERNAL | APOPTOTIC RESPONSES | TYROSINE KINASE INHIBITOR | DEATH | MUTATIONS | BH3-ONLY PROTEINS | CHRONIC MYELOID-LEUKEMIA | Receptor, Epidermal Growth Factor - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Biphenyl Compounds - therapeutic use | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Nitrophenols - therapeutic use | Apoptosis Regulatory Proteins - genetics | Cell Death - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - biosynthesis | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Proto-Oncogene Proteins - genetics | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Drug Synergism | Cell Death - physiology | Sulfonamides - therapeutic use | Quinazolines - therapeutic use | Proto-Oncogene Proteins - physiology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Apoptosis Regulatory Proteins - physiology | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Quinazolines - pharmacology | Care and treatment | Research | Mutation (Biology) | Risk factors | Cancer | Index Medicus | Lung | Genetics and Genomics | Oncology | Biochemistry | Pharmacology and Toxicology | Cell Biology
Journal Article