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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1996, Volume 93, Issue 24, pp. 14002 - 14007
Journal Article
mAbs, ISSN 1942-0862, 07/2015, Volume 7, Issue 4, pp. 778 - 791
Herein, we describe the generation and characterization of BI 655066, a novel, highly potent neutralizing anti-interleukin-23 (IL23) monoclonal antibody in... 
BI 655066 | pharmacokinetic profile | immunogen design | biophysical assessment | humanization | IL23 | IL23R | MONOCLONAL-ANTIBODY | variable heavy | phosphate-buffered saline | IL-23 | AUC | V-H | analytical ultracentrifugation | Chemical Computing Group | SPR | HCLF | INTERLEUKIN-17 | surface plasmon resonance | glycine | Janus kinase 2 | JAK2 | Th17 | CDRs | electro-osmotic flow | PBS | UV | complementarity-determining regions | IL12 | DISTINCT | Interleukin 12 | SEC | INFLAMMATION | tyrosine | high concentration liquid formulation | PSORIASIS | C-H | MEDICINE, RESEARCH & EXPERIMENTAL | C | RU | goat anti-human IgG gamma antibody | Interleukin-23 | F | size-exclusion chromatography | G | RECEPTOR | electrospray ionization | IL12 receptor subunit beta 1 | constant kappa | V | Y | tyk2 | ESI | T helper 17 cells | IL12RB1 | pharmacokinetic | DMF | ADCC | EOF | T-CELLS | CHARGE | resonance units | constant region | phenylalanine | CCG | antibody-dependent cell-mediated cytotoxicity | dimethylformamide | GAHA | ultraviolet | variable kappa | variable | IL23 receptor | tyrosine kinase 2 | PK | Psoriasis - immunology | Interleukin-23 Subunit p19 - antagonists & inhibitors | Psoriasis - drug therapy | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - pharmacokinetics | Macaca fascicularis | Antibodies, Neutralizing - pharmacology | Crohn Disease - immunology | Drug Delivery Systems | Antibodies, Neutralizing - immunology | Animals | Crohn Disease - drug therapy | Th17 Cells - immunology | Interleukin-23 Subunit p19 - immunology | Antibodies, Monoclonal - immunology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2016, Volume 359, Issue 1, pp. 37 - 44
Journal Article