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Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6029, pp. 600 - 603
Journal Article
Science, ISSN 0036-8075, 07/2015, Volume 349, Issue 6246, pp. 377 - 378
  To prevent immune responses to our own bodies, a series of immune checkpoints exist. Cytotoxic T lymphocyte antigen-4 (CTLA-4) operates the earliest... 
IMMUNE DYSREGULATION | ENTEROPATHY | MULTIDISCIPLINARY SCIENCES | POLYENDOCRINOPATHY | MUTATIONS | ENDOCYTOSIS | PROTEINS | T-CELLS | Lymphocyte receptors | Antigens | Protein expression | Immune system | Anchors | Proteins | Recycling | Lymphocytes | Tumors
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2015, Volume 112, Issue 2, pp. 524 - 529
Journal Article
Advances in Immunology, ISSN 0065-2776, 01/2014, Volume 124, p. 95
  T cell activation is a key event in the adaptive immune response and vital to the generation of both cellular and humoral immunity. Activation is required... 
Cellular biology | Lymphocytes | Immune system
Journal Article
Journal Article
Thorax, ISSN 0040-6376, 12/2013, Volume 68, Issue 12, pp. 1176 - 1178
While the innate immune system has long been implicated in the pathogenesis of COPD, a role for the acquired immune system is less well studied. The increasing... 
COPD Exacerbations | Copd u Mechanisms | RESPIRATORY SYSTEM | Tobacco and the Lung | Lymphocyte Count | T-Lymphocytes, Regulatory | Pulmonary Disease, Chronic Obstructive - immunology | Autoimmunity - immunology | Humans | Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 6, pp. 1660 - 1670.e16
Background Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS). Methods Twelve patients with cDGS... 
Allergy and Immunology | DiGeorge syndrome | athymia | thymus transplantation | ALLERGY | AUTOIMMUNE REGULATOR | IMMUNOLOGY | RECONSTITUTION | T-CELLS | Immunological deficiency syndromes | Hemolysis | Thyroiditis | Thrombocytopenia | Antigens | Complications | Septic shock | Antimicrobial agents | Transplantation | Lymphocytes T | T cell receptors | Infections | Patients | Inflammatory diseases | Defects | CD4 antigen | Thymus | T-cell receptor | Thymopoiesis | Biopsy | Lymphocytes | Stem cells | Thymic hypoplasia | Mutation | Neutropenia | Index Medicus | Abridged Index Medicus | HSCT, Hematopoietic stem cell transplantation | TCR, T-cell receptor | mTEC, Medullary thymic epithelial cell | CTLA4, Cytotoxic T lymphocyte–associated antigen 4 | ATG, Antithymocyte globulin | cTEC, Cortical thymic epithelial cell | EpCam, Epithelial cell adhesion molecule | FoxP3, Forkhead box P3 | TEC, Thymic epithelial cell | Treg, Regulatory T | AIRE, Autoimmune regulator | CHARGE, Coloboma, heart defects, atresia choanae, retardation of growth and development, genital abnormalities, ear abnormalities | DGS, DiGeorge syndrome | CMV, Cytomegalovirus | LCL, Lymphoblastoid cell line | TREC, T-cell receptor signal joint excision circle | cDGS, Complete DiGeorge syndrome | SCID, Severe combined immunodeficiency | deafness | CK, Cytokeratin
Journal Article