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Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2016, Volume 77, Issue 3, pp. 527 - 538
PF-00337210 is an oral, highly selective vascular endothelial growth factor receptor (VEGFR) inhibitor. We evaluated a composite of biomarkers in real time to... 
DCEMRI imaging | Medicine & Public Health | Tyrosine kinase inhibitor | Oncology | Cancer Research | Pharmacodynamic analysis | VEGF receptor | Pharmacology/Toxicology | 1ST-LINE TREATMENT | ADVANCED BREAST-CANCER | ANTITUMOR-ACTIVITY | RENAL-CELL CARCINOMA | FACTOR RECEPTOR INHIBITOR | LUNG-CANCER | ONCOLOGY | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | ANGIOGENESIS INHIBITOR | ENDOTHELIAL GROWTH-FACTOR | Humans | Middle Aged | Biomarkers, Pharmacological | Magnetic Resonance Imaging - methods | Benzofurans - administration & dosage | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Quinolines - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Antineoplastic Agents - adverse effects | Aged, 80 and over | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Adult | Female | Benzofurans - therapeutic use | Drug Administration Schedule | Treatment Outcome | Benzofurans - adverse effects | Neoplasms - drug therapy | Maximum Tolerated Dose | Aged | Quinolines - therapeutic use | Neoplasms - pathology | Quinolines - adverse effects | Hypertension | Medical research | Care and treatment | Medicine, Experimental | Hemoglobin | Vascular endothelial growth factor | Tumors | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2006, Volume 116, Issue 10, pp. 2610 - 2621
Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVE REGENERATION | BASAL LAMINA | ANGIOGENESIS INHIBITORS | BLOOD-VESSELS | EXTRACELLULAR-MATRIX | MUSCLE ACTIN EXPRESSION | ENDOTHELIAL SPROUTS | BASEMENT-MEMBRANES | GROWTH IN-VIVO | ESTABLISHED TUMORS | Basement Membrane - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Actins - metabolism | Endothelium, Vascular - drug effects | Vascular Endothelial Growth Factor A - metabolism | Basement Membrane - pathology | Carcinoma, Lewis Lung - blood supply | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Insulinoma - blood supply | Pericytes - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Organic Chemicals - pharmacology | Angiogenesis Inhibitors - therapeutic use | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Imidazoles - therapeutic use | Collagen Type IV - immunology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Collagen Type IV - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Pericytes - metabolism | Insulinoma - drug therapy | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Neoplasms - blood supply | Treatment Outcome | Imidazoles - pharmacology | Basement Membrane - metabolism | Carcinoma, Lewis Lung - drug therapy | Neoplasms - drug therapy | Indazoles - pharmacology | Animals | Endothelium, Vascular - metabolism | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Carcinoma, Lewis Lung - pathology | Matrix Metalloproteinase Inhibitors | Endothelium, Vascular - pathology | Insulinoma - pathology | Mice | Neovascularization, Pathologic - metabolism | Neoplasms - pathology | Indazoles - therapeutic use | Care and treatment | Research | Vascular endothelial growth factor | Cancer
Journal Article
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 2004, Volume 165, Issue 1, pp. 35 - 52
Journal Article
Clinical Pharmacology in Drug Development, ISSN 2160-763X, 03/2015, Volume 4, Issue 2, pp. 89 - 98
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1362 - 1373
Journal Article
Journal Article
Magnetic Resonance Imaging, ISSN 0730-725X, 2007, Volume 25, Issue 3, pp. 319 - 327
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 12/2001, Volume 25, Issue 6, pp. 717 - 724
Mechanical ventilation has become an indispensable therapeutic modality for patients with respiratory failure. However, a serious potential complication of MV... 
COLLAGENASE-STIMULATORY FACTOR | IV COLLAGENASE | CELLS | RNA | RESPIRATORY SYSTEM | MECHANICAL-STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-SITU HYBRIDIZATION | EXTRACELLULAR-MATRIX | EXPRESSION | CELL BIOLOGY | ADAM17 Protein | Barotrauma - etiology | Fibroblasts - enzymology | Capillary Permeability | Organic Chemicals | Membrane Glycoproteins - biosynthesis | Stress, Mechanical | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Respiratory Distress Syndrome, Adult - etiology | Lung - enzymology | Basigin | Enzyme Inhibitors - administration & dosage | Ventilators, Mechanical | Matrix Metalloproteinase 9 - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Models, Animal | Antineoplastic Agents - pharmacology | Lung Injury | Barotrauma - drug therapy | Drug Evaluation, Preclinical | Metalloendopeptidases - antagonists & inhibitors | Acute Disease | Antigens, Neoplasm | Respiratory Distress Syndrome, Adult - prevention & control | Matrix Metalloproteinase 2 - metabolism | Enzyme Inhibitors - pharmacology | Injections, Intraperitoneal | Enzyme Induction | Positive-Pressure Respiration - adverse effects | Rats | ADAM Proteins | Enzyme Inhibitors - therapeutic use | Pressure | Rats, Sprague-Dawley | Culture Media, Conditioned | Animals | Fibroblasts - drug effects | Matrix Metalloproteinase Inhibitors | Barotrauma - enzymology | Tumor Necrosis Factor-alpha - biosynthesis | Antigens, CD | Premedication
Journal Article