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by Steffens, Michael and Leu, Costin and Ruppert, Ann-Kathrin and Zara, Federico and Striano, Pasquale and Robbiano, Angela and Capovilla, Giuseppe and Tinuper, Paolo and Gambardella, Antonio and Bianchi, Amedeo and La neve, Angela and Crichiutti, Giovanni and de kovel, Carolien G.F and Trenité, Dorothée Kasteleijn-Nolst and de haan, Gerrit-Jan and Lindhout, Dick and Gaus, Verena and Schmitz, Bettina and Janz, Dieter and Weber, Yvonne G and Becker, Felicitas and Lerche, Holger and Steinhoff, Bernhard J and Kleefuß-Lie, Ailing A and Kunz, Wolfram S and Surges, Rainer and Elger, Christian E and Muhle, Hiltrud and Von spiczak, Sarah and Ostertag, Philipp and Helbig, Ingo and Stephani, Ulrich and Møller, Rikke S and Hjalgrim, Helle and Dibbens, Leanne M and Bellows, Susannah and Oliver, Karen and Mullen, Saul and Scheffer, Ingrid E and Berkovic, Samuel F and Everett, Kate V and Gardiner, Mark R and Marini, Carla and Guerrini, Renzo and Lehesjoki, Anna-Elina and Siren, Auli and Guipponi, Michel and Malafosse, Alain and Thomas, Pierre and Nabbout, Rima and Baulac, Stephanie and Leguern, Eric and Guerrero, Rosa and Serratosa, Jose M and Reif, Philipp S and Rosenow, Felix and Mörzinger, Martina and Feucht, Martha and Zimprich, Fritz and Kapser, Claudia and Schankin, Christoph J and Suls, Arvid and Smets, Katrin and De jonghe, Peter and Jordanova, Albena and Caglayan, Hande and Yapici, Zuhal and Yalcin, Destina A and Baykan, Betul and Bebek, Nerses and Ozbek, Ugur and Gieger, Christian and Wichmann, Heinz-Erich and Balschun, Tobias and Ellinghaus, David and Franke, Andre and Meesters, Christian and Becker, Tim and Wienker, Thomas F and Hempelmann, Anne and Schulz, Herbert and Rüschendorf, Franz and Leber, Markus and Pauck, Steffen M and Trucks, Holger and Toliat, Mohammad R and Nürnberg, Peter and Avanzini, Giuliano and Koeleman, Bobby P.C and Sander, Thomas and Weckhuysen, Sarah and Claes, Lieve and Deprez, Liesbet and Van Dyck, Tine and Deconinck, Tine and Velizarova, Reana and Dimova, Petya and Radionova, Melania and Tournev, Ivaylo and Kancheva, Dahlia and ... and EMINET Consortium and EPICURE Consortium and EMINet Consortium
Human Molecular Genetics, ISSN 0964-6906, 12/2012, Volume 21, Issue 24, pp. 5359 - 5372
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/1997, Volume 94, Issue 2, pp. 690 - 694
Journal Article
Science, ISSN 0036-8075, 10/2004, Volume 306, Issue 5693, pp. 67 - 68
The drug discovery equivalent of reality-based television programs is the forward chemical genetic screen, in which cells or extracts are tested against a... 
Molecules | Enzymes | Molecular genetics | Mitosis | Ubiquitins | Blood cells | Medical treatment | Cell cycle | Perspectives | Cyclins | Genetic screening | SYSTEM | TARGET | SMALL MOLECULES | MULTIDISCIPLINARY SCIENCES | PROTEASOME | PROTEOLYSIS | DISCOVERY | Pharmaceutical research | Methods | Proteins | Genetics | Mutation | Cellular biology
Journal Article
by Allen, Andrew S and Bellows, Susannah T and Berkovic, Samuel F and Bridgers, Joshua and Burgess, Rosemary and Cavalleri, Gianpiero and Chung, Seo-Kyung and Cossette, Patrick and Delanty, Norman and Dlugos, Dennis and Epstein, Michael P and Freyer, Catharine and Goldstein, David B and Heinzen, Erin L and Hildebrand, Michael S and Johnson, Michael R and Kuzniecky, Ruben and Lowenstein, Daniel H and Marson, Anthony G and Mayeux, Richard and Mebane, Caroline and Mefford, Heather C and O'Brien, Terence J and Ottman, Ruth and Petrou, Steven and Petrovski, Slavgé and Pickrell, William O and Poduri, Annapurna and Radtke, Rodney A and Rees, Mark I and Regan, Brigid M and Ren, Zhong and Scheffer, Ingrid E and Sills, Graeme J and Thomas, Rhys H and Wang, Quanli and Abou-Khalil, Bassel and Alldredge, Brian K and Amrom, Dina and Andermann, Eva and Andermann, Frederick and Bautista, Jocelyn F and Bluvstein, Judith and Boro, Alex and Cascino, Gregory D and Consalvo, Damian and Crumrine, Patricia and Devinsky, Orrin and Fiol, Miguel and Fountain, Nathan B and French, Jacqueline and Friedman, Daniel and Geller, Eric B and Glauser, Tracy and Glynn, Simon and Haas, Kevin and Haut, Sheryl R and Hayward, Jean and Helmers, Sandra L and Joshi, Sucheta and Kanner, Andres and Kirsch, Heidi E and Knowlton, Robert C and Kossoff, Eric H and Kuperman, Rachel and Motika, Paul V and Novotny, Edward J and Paolicchi, Juliann M and Parent, Jack M and Park, Kristen and Sadleir, Lynette G and Shellhaas, Renée A and Sherr, Elliott H and Shih, Jerry J and Shinnar, Shlomo and Singh, Rani K and Sirven, Joseph and Smith, Michael C and Sullivan, Joseph and Thio, Liu Lin and Venkat, Anu and Vining, Eileen P.G and Von Allmen, Gretchen K and Weisenberg, Judith L and Widdess-Walsh, Peter and Winawer, Melodie R and Epilepsy Phenome-Genome Proj and Epi4k Consortium and Epilepsy Phenome/Genome Project and Epi4K consortium
Lancet Neurology, The, ISSN 1474-4422, 2017, Volume 16, Issue 2, pp. 135 - 143
Summary Background Despite progress in understanding the genetics of rare epilepsies, the more common epilepsies have proven less amenable to traditional... 
Neurology | RISK | SEIZURES | CLINICAL NEUROLOGY | MUTATION | DISEASE | Epilepsy, Generalized - genetics | Exome | Genetic Variation | Genetic Predisposition to Disease | Humans | Epilepsies, Partial - genetics | Sequence Analysis, DNA | Case-Control Studies | Genetic research | Genetic aspects | Analysis | Epilepsy | Proteins | Studies | Disease | Genomes | Mutation | Family medical history | Patients
Journal Article
2006, AD-a460 468.
I am developing a novel cell-based small-molecule screening approach that can identify inhibitors of any non-essential protein function through a surrogate... 
inhibitors | saccharomycetes | high-throughput screening | yeasts | antigens | targets | suppressors | genome | mutations | genetics | genome-wide genetic analysis | sl(synthetic lethailty) | chemical genetics | proteins | oncogenesis | throughput
Government Document
ISSN 1742-206X, 10/2015, Volume 11, Issue 11, pp. 3129 - 3136
Identifying Saccharomyces cerevisiae genome-wide gene deletion mutants that confer hypersensitivity to a xenobiotic aids the elucidation of its mechanism of... 
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 2004, Volume 8, Issue 1, pp. 81 - 90
Large-scale analysis of genetic and physical interaction networks has begun to reveal the global organization of the cell. Cellular phenotypes observed at the... 
ORGANIZATION | BIOPHYSICS | LETHALITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | COMPLEXES | GENE-EXPRESSION | PROTEIN-PROTEIN INTERACTIONS | GLOBAL ANALYSIS | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | SYSTEMS BIOLOGY | Animals | Signal Transduction | Humans | Cells - chemistry | Cells - metabolism | Protein Binding | Genetics | Drug Evaluation, Preclinical
Journal Article
Molecular BioSystems, ISSN 1742-206X, 01/2014, Volume 10, Issue 1, pp. 128 - 137
The pleiotropic drug response (PDR) or multidrug resistance (MDR) are cellular defence mechanisms present in all species to deal with potential toxicity from... 
YEAST | RECRUITMENT | TRANSCRIPTIONAL ACTIVATION | TRANSPORTER | CHROMATIN | PDR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MULTIDRUG-RESISTANCE | COACTIVATORS | DELETION | Index Medicus
Journal Article