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Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 10, pp. 839 - 847
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2)... 
ISOZYME | INHIBITION | FRUCTOSE-1,6-BISPHOSPHATE | THYROID-HORMONE | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOFORM | BINDING PROTEIN | CANCER-CELL METABOLISM | TUMOR-GROWTH | NUCLEAR TRANSLOCATION | Genes | Cells | Cancer | Tumors | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
EMBO reports, ISSN 1469-221X, 09/2015, Volume 16, Issue 9, pp. 1203 - 1218
S treptococcus pneumoniae coinfection is a major cause of influenza‐associated mortality; however, the mechanisms underlying pathogenesis or protection remain... 
influenza | related apoptosis‐inducing ligand | treptococcus pneumoniae | 2 | CCR | S | TRAIL | C‐C‐chemokine receptor type | ) | neutrophil | TNF | TNF-related apoptosis-inducing ligand (TRAIL) | C-C-chemokine receptor type (CCR) 2 | Streptococcus pneumoniae | VIRUS-INFECTION | DENDRITIC CELLS | PANDEMIC INFLUENZA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LETHAL SYNERGISM | NECROSIS-FACTOR-ALPHA | CELL BIOLOGY | BACTERIAL PNEUMONIA | NEGATIVE REGULATION | MOUSE MODEL | PNEUMOCOCCAL PNEUMONIA | TNF-ALPHA | Receptors, CCR2 - genetics | Lung - microbiology | Streptococcus pneumoniae - growth & development | Influenza A Virus, H3N2 Subtype | Humans | Orthomyxoviridae Infections - complications | Monocytes - immunology | Coinfection - physiopathology | Streptococcus pneumoniae - immunology | Lung - virology | Pneumococcal Infections - immunology | Streptococcus pneumoniae - pathogenicity | Tumor Necrosis Factor-alpha - immunology | Cytokines - immunology | Disease Models, Animal | Pneumococcal Infections - complications | Disease Susceptibility | Coinfection - immunology | Mice, Inbred C57BL | Neutrophils - immunology | Lung - physiopathology | TNF-Related Apoptosis-Inducing Ligand - metabolism | Animals | Mice | Receptors, CCR2 - deficiency | Lung - immunology | Orthomyxoviridae Infections - immunology | Ligands | Lungs | Influenza | Streptococcus infections | Apoptosis | Index Medicus
Journal Article
Science, ISSN 0036-8075, 02/2018, Volume 359, Issue 6378, pp. 883 - 883
Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and... 
STRUCTURED ILLUMINATION | OUTER-MEMBRANE | BAX ACTIVATION | FUSION | PROTEIN DRP1 | DNA | MULTIDISCIPLINARY SCIENCES | FISSION | CYTOCHROME-C RELEASE | CELL-DEATH | PERMEABILITY TRANSITION | DNA, Mitochondrial - metabolism | Cytochromes c - metabolism | Humans | Mice, Inbred C57BL | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Gene Knockout Techniques | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Mitochondrial Membranes - metabolism | Animals | Mitochondrial Membranes - chemistry | Fibroblasts | Mice | HeLa Cells | bcl-2-Associated X Protein - genetics | Apoptosis | Cytochrome | Viral diseases | Immune clearance | Radiation | Mitochondrial DNA | Cytosol | Proteins | Signal transduction | Mitochondria | Escape systems | Human immunodeficiency virus--HIV | Deoxyribonucleic acid--DNA | Efflux | Mortality | Real time | Electron microscopy | Embryos | Cytochrome c | Rheumatoid arthritis | Irradiation | Pores | Dismantling | Pore-forming proteins | Pore formation | Membranes | Bax protein | Calcium | Genomes | Activation | Arthritis | Inflammatory diseases | Pathways | Moisture content | Vector-borne diseases | Inner membranes | Immune response | Oligomerization | Dengue | Caspase | Embryo fibroblasts | Light (illumination) | Damage patterns | Chronic conditions | Microscopy | Cell death | Interferon | Porosity | Autoimmune diseases | Cytoplasm | Index Medicus
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 05/2009, Volume 179, Issue 10, pp. 883 - 893
Rationale: One of the immunopathological features of allergic inflammation is the infiltrationof helper T type 2 (Th2) cells to the site of disease. Activation... 
Innate immunity | Neutrophil | Eosinophil | Asthma | ACTIVATED PROTEIN-KINASE | DENDRITIC CELLS | OX40 LIGAND | asthma | ALLERGIC AIRWAY INFLAMMATION | neutrophil | CUTTING EDGE | innate immunity | INHALED ANTIGEN | RESPIRATORY SYSTEM | IMMUNE-RESPONSES | TOLL-LIKE RECEPTORS | ANTIGEN-PRESENTING CELLS | eosinophil | ASTHMATIC-PATIENTS | CRITICAL CARE MEDICINE
Journal Article
Whitehorse Star, 01/2018
Newspaper Article
Cell Reports, ISSN 2211-1247, 07/2019, Volume 28, Issue 1, pp. 245 - 256.e4
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target... 
lung | microbiota | influenza | type I interferon (IFN) | gut | tonic IFN signaling | antibiotics | anti-viral protection | RESPONSES | COMMENSAL | THRESHOLD | INNATE | COMPONENTS | RECEPTOR | ALPHA | DEGRADATION | VIRAL RESISTANCE | BLOCKADE | CELL BIOLOGY
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 131, Issue 5, pp. 1331 - 1339.e10
Journal Article