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NATURE COMMUNICATIONS, ISSN 2041-1723, 10/2019, Volume 10, Issue 1, pp. 1 - 11
Sialic acids are a family of related sugars that play essential roles in many biological events intimately linked to cellular recognition in both health and... 
3-DIMENSIONAL STRUCTURE | NEURAMINIDASE | ENZYME | MECHANISM | ROLES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DEGRADATION | POLYSIALIC ACID | TRANS-SIALIDASE | POLYSACCHARIDE | Acids | Therapeutic applications | Hot springs | Hydrophobicity | Sialic acids | Constellations | Sugars | Glycan
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 05/2018, Volume 24, Issue 29, pp. 7464 - 7473
endo‐α‐1,2‐Mannosidases and ‐mannanases, members of glycoside hydrolase family 99 (GH99), cleave α‐Glc/Man‐1,3‐α‐Man‐OR structures within mammalian N‐linked... 
X-ray crystallography | glycosidase | inhibitors | enzymes | imidazole rings | Tyrosine | Hydrolase | Exploration | Nitrogen | Mannan | Polysaccharides | Inhibitors | Acids | Mannanases | Imidazole | Catalysis | Basicity | Carboxylates | Glycoside hydrolase | Full Paper | Full Papers
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 8/2019, Volume 17, Issue 34, pp. 7863 - 7869
Enzyme transition-state mimics can act as powerful inhibitors and allow structural studies that report on the conformation of the transition-state. Here,... 
Bacteria | Mannosidase | Dogs | Conformation
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 12/2019, Volume 53, pp. 131 - 144
The post-translational modification of proteins by O-linked -acetylglucosamine (O-GlcNAc) dynamically programmes cellular physiology to maintain homoeostasis... 
Post-translational modification | Transcription | Glycosyltransferase | Spliceoforms | Glycoprotein | glycosylation | Glycans | O-GlcNAc | Subcellular localization | Glycosidase | O-GlcNAcylation | miRNA | Post-transcriptional regulation | Enzyme regulation | GlcNAc | Hexosamine | Retained intron
Journal Article
ChemBioChem, ISSN 1439-4227, 06/2019, Volume 20, Issue 11, pp. 1365 - 1368
The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α‐l‐fucosidases, are important targets for... 
glycosidases0 | fucosidases | carbamate | enzyme inhibitors | hydroximolactone | Inhibitors | Hybridization | Glycoconjugates | Crystallography | Sugar | Fucose | Communications | Communication
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2017, Volume 53, Issue 93, pp. 12528 - 12531
Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational... 
Biological properties | Profiling | Isomers | Glycosidases | Substrates | Deoxygenation
Journal Article
Organic & biomolecular chemistry, 08/2019
Enzyme transition-state mimics can act as powerful inhibitors and allow structural studies that report on the conformation of the transition-state. Here,... 
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 11, pp. 7772 - 7779
Modulation of enzyme activity is a powerful means of probing cellular function and can be exploited for diverse applications. Here, we explore a method of... 
SITE | CATALYSIS | MUTAGENESIS | HUMAN O-GLCNACASE | INHIBITION | MECHANISM | PROTEIN-KINASE | CHEMICAL-MODIFICATION | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | SMALL-MOLECULE ACTIVATORS | Enzymes | Covalence | Enzyme activity | Inhibitors | Fragments | Activation | Tethering | Catalytic activity | Catalysis | Fragmentation
Journal Article
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 1/2019, Volume 17, Issue 2, pp. 398 - 398
Correction for 'Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo -xyloglucanases' by Namrata... 
Synthesis | Inhibitors | Oligosaccharides
Journal Article
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 05/2018, Volume 24, Issue 29, pp. 7464 - 7473
Journal Article