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1. Full Text Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
by De Henau, Olivier and Rausch, Matthew and Winkler, David and Campesato, Luis Felipe and Liu, Cailian and Cymerman, Daniel Hirschhorn and Budhu, Sadna and Ghosh, Arnab and Pink, Melissa and Tchaicha, Jeremy and Douglas, Mark and Tibbitts, Thomas and Sharma, Sujata and Proctor, Jennifer and Kosmider, Nicole and White, Kerry and Stern, Howard and Soglia, John and Adams, Julian and Palombella, Vito J and McGovern, Karen and Kutok, Jeffery L and Wolchok, Jedd D and Merghoub, Taha
Nature (London), ISSN 0028-0836, 2016, Volume 539, Issue 7629, pp. 443 - 447
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Myeloid Cells - enzymology | Phosphoinositide-3 Kinase Inhibitors | Humans | Male | Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes, Cytotoxic - drug effects | Neoplasm Metastasis - drug therapy | Myeloid Cells - immunology | Female | Myeloid Cells - drug effects | Disease Models, Animal | Immune Tolerance - drug effects | T-Lymphocytes, Cytotoxic - immunology | Tumor Microenvironment - drug effects | Mice, Inbred C57BL | Drug Resistance, Neoplasm - immunology | Melanoma - pathology | Tumor Microenvironment - immunology | Phenotype | Animals | Cell Cycle Checkpoints - drug effects | Melanoma - immunology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Index Medicus
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2. Full Text Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis
by Dubois-Vedrenne, Ingrid and De Henau, Olivier and Robert, Virginie and Langa, Francina and Javary, Joaquim and Al Delbany, Diana and Vosters, Olivier and Angelats-Canals, Edgar and Vernimmen, Maxime and Luangsay, Souphalone and Wittamer, Valérie and Parmentier, Marc
Frontiers in oncology, ISSN 2234-943X, 11/2019, Volume 9, pp. 1253 - 1253
chemerin | ChemR23 | chemical carcinogenesis | CMKLR1 | squamous cell carcinoma | Life Sciences & Biomedicine | Oncology | Science & Technology | Squamous cell carcinoma | Care and treatment | Analysis | Genetic engineering | Models | Skin | Skin cancer | Cancer | Life Sciences
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3. Full Text Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2
by De Henau, Olivier and Degroot, Gaetan-Nagim and Imbault, Virginie and Robert, Virginie and De Poorter, Cédric and McHeik, Saria and Galés, Céline and Parmentier, Marc and Springael, Jean-Yves
PloS one, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0164179 - e0164179
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | MAP Kinase Signaling System - physiology | Cricetulus | Receptors, CCR - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Receptors, Chemokine - metabolism | beta-Arrestin 2 - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Chemotaxis - physiology | Chemotactic Factors - metabolism | HEK293 Cells | Ligands | Signal Transduction - physiology | Chemokines - metabolism | Mice | CHO Cells | G proteins | Comparative analysis | Membrane proteins | Protein binding | Binding | Phosphorylation | Dendritic cells | Extracellular signal-regulated kinase | Activation | C-Terminus | Kinases | Recruitment | Proteins | Signaling | Receptors | Properties (attributes) | Internalization | Isoforms | Affinity | Receptor mechanisms | Biosensors | Chemokines | Index Medicus
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4. Full Text Corrigendum: Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis
by Dubois-Vedrenne, Ingrid and De Henau, Olivier and Robert, Virginie and Langa, Francina and Javary, Joaquim and Al Delbany, Diana and Vosters, Olivier and Angelats-Canals, Edgar and Vernimmen, Maxime and Luangsay, Souphalone and Wittamer, Valérie and Parmentier, Marc
Frontiers in oncology, ISSN 2234-943X, 06/2020, Volume 10, pp. 977 - 977
chemerin | ChemR23 | chemical carcinogenesis | CMKLR1 | squamous cell carcinoma
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5. Full Text Mouse ChemR23 Is Expressed in Dendritic Cell Subsets and Macrophages, and Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model
by Luangsay, Souphalone and Wittamer, Valerie and Bondue, Benjamin and De Henau, Olivier and Rouger, Laurie and Brait, Maryse and Franssen, Jean-Denis and de Nadai, Patricia and Huaux, Francois and Parmentier, Marc
The Journal of immunology (1950), ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6489 - 6499
Life Sciences & Biomedicine | Immunology | Science & Technology | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Dendritic Cells - immunology | Bronchoalveolar Lavage Fluid - immunology | Calcium - immunology | Aequorin - immunology | Aequorin - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Chemotactic Factors - pharmacology | Peptides - metabolism | Chemotactic Factors - metabolism | Pneumonia - chemically induced | Killer Cells, Natural - immunology | Pneumonia - immunology | Dendritic Cells - drug effects | Bronchoalveolar Lavage Fluid - cytology | Chemotaxis - immunology | Neutrophils - metabolism | Apoproteins - metabolism | Dendritic Cells - metabolism | Macrophages - immunology | Disease Models, Animal | Recombinant Proteins - metabolism | Chemotactic Factors - immunology | Acute Disease | Lung - pathology | Mice, Inbred C57BL | Neutrophils - drug effects | Peptides - immunology | Neutrophils - immunology | Chemotaxis - drug effects | Mice, Knockout | Macrophages - metabolism | Animals | Recombinant Proteins - immunology | Intercellular Signaling Peptides and Proteins - pharmacology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Killer Cells, Natural - drug effects | Mice | Receptors, G-Protein-Coupled - genetics | Apoproteins - immunology | Killer Cells, Natural - metabolism | Pneumonia - metabolism | Chemokines | Intercellular Signaling Peptides and Proteins - immunology | Lung - immunology | Index Medicus | Abridged Index Medicus
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6. Full Text Overcoming resistance to checkpoint blockade therapy by targeting PI3K in myeloid cells
by De Henau, Olivier and Rausch, Matthew and Winkler, David and Campesato, Luis Felipe and Liu, Cailian and Cymerman, Daniel Hirschhorn and Budhu, Sadna and Ghosh, Arnab and Pink, Melissa and Tchaicha, Jeremy and Douglas, Mark and Tibbitts, Thomas and Sharma, Sujata and Proctor, Jennifer and Kosmider, Nicole and White, Kerry and Stern, Howard and Soglia, John and Adams, Julian and Palombella, Vito J and McGovern, Karen and Kutok, Jeffery L and Wolchok, Jedd D and Merghoub, Taha
Nature (London), ISSN 0028-0836, 11/2016, Volume 539, Issue 7629, p. 443
Immunotherapy | Methods | Genotype & phenotype | Immunoglobulins | Lymphocytes | Tumors | Cancer
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7. Full Text Phase 1b/2 study of nivolumab in combination with an anti–IL-8 monoclonal antibody, BMS-986253, in a biomarker-enriched population of patients with advanced cancer
by Melero Bermejo, Ignacio and Jaffee, Elizabeth M and Davar, Diwakar and Cardarelli, Josephine and Williams, Daphne and Phillips, Penny and Carleton, Michael and Zhou, Ming and De Henau, Olivier and Monga, Manish and Drake, Charles G
Journal of clinical oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. TPS3109 - TPS3109
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8. Full Text Serum interleukin 8 (IL-8) may serve as a biomarker of response to immuno-oncology (I-O) therapy
by Carleton, Michael and Zhou, Ming and De Henau, Olivier and Phillips, Penny and Chen, Tian and Feng, Ye and Huang, Shu-Pang and Walsh, Alice and Reilly, Timothy P and Melero Bermejo, Ignacio
Journal of clinical oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. 3025 - 3025
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9. Full Text The optimal utilization proportion of external beam radiotherapy in European countries: An ESTRO-HERO analysis
by Borras, Josep M and Lievens, Yolande and Dunscombe, Peter and Coffey, Mary and Malicki, Julian and Corral, Julieta and Gasparotto, Chiara and Defourny, Noemie and Barton, Michael and Verhoeven, Rob and van Eycken, Liesbeth and Primic-Zakelj, Maja and Trojanowski, Maciej and Strojan, Primoz and Grau, Cai and HERO consortium
Radiotherapy and oncology, ISSN 0167-8140, 2015, Volume 116, Issue 1, pp. 38 - 44
Hematology, Oncology and Palliative Medicine | Optimal utilization | European countries | Planning | Radiotherapy | Oncology | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Neoplasms - radiotherapy | Neoplasms - pathology | Europe | Humans | Neoplasms - epidemiology | Incidence | Analysis | Index Medicus | Health facilities | Radioteràpia | Radiologia | Gestió de personal | Surveys | Gestió hospitalària | Personnel management | Enquestes | Equipaments sanitaris | Hospital administration | Radiology | Europa
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10. Full Text Abstract 574: Phosphatidylserine targeting antibody in combination with tumor radiation and immune checkpoint blockade promotes anti-tumor activity in mouse B16 melanoma
by Budhu, Sadna and Henau, Olivier De and Zappasodi, Roberta and Giese, Rachel and Campesato, Luis F and Barker, Christopher and Freimark, Bruce and Hutchins, Jeff and Wolchok, Jedd D and Merghoub, Taha
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 574 - 574
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11. Full Text Abstract 554: Checkpoint blockade therapy is improved by altering the immune suppressive microenvironment with IPI-549, a potent and selective inhibitor of PI3K-gamma, in preclinical models
by De Henau, Olivier and Merghoub, Taha and Winkler, David and Sharma, Sujata and Pink, Melissa and Tchaicha, Jeremy and Rausch, Matthew and Proctor, Jennifer and Kosmider, Nicole and Soglia, John and Palombella, Vito and Kutok, Jeffery L and Wolchok, Jedd D and McGovern, Karen
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 554 - 554
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12. Full Text ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia
by Bondue, Benjamin and Vosters, Olivier and de Nadai, Patricia and Glineur, Stéphanie and de Henau, Olivier and Luangsay, Souphalone and van Gool, Frédéric and Communi, David and de Vuyst, Paul and Desmecht, Daniel and Parmentier, Marc
PLoS pathogens, ISSN 1553-7366, 11/2011, Volume 7, Issue 11, pp. e1002358 - e1002358
Murine pneumonia virus - pathogenicity | Murine pneumonia virus - metabolism | Receptors, G-Protein-Coupled - metabolism | Dendritic Cells - immunology | Intercellular Signaling Peptides and Proteins - biosynthesis | Viral Load | Murine pneumonia virus - immunology | Pneumovirus Infections - metabolism | Receptors, G-Protein-Coupled - immunology | Pneumonia, Viral - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Interferon Type I - biosynthesis | Chemotactic Factors - biosynthesis | Chemotactic Factors - metabolism | Dendritic Cells - metabolism | Inflammation Mediators | Mice, Inbred C57BL | Receptors, G-Protein-Coupled - biosynthesis | Pneumonia, Viral - immunology | Interferon Type I - deficiency | Mice, Knockout | Pneumovirus Infections - immunology | Animals | Mice | Receptors, G-Protein-Coupled - genetics | Chemokines | Lung - immunology | Antiviral agents | Viral pneumonia | Care and treatment | Dendritic cells | Physiological aspects | Research | G proteins | Health aspects | Immunology | Rodents | Influenza | Mortality | Viruses | Cytotoxicity | Infections | Chronic obstructive pulmonary disease | Experiments | Immune system | Recruitment | Index Medicus
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13. Full Text Abstract 3891: Tackling the obstacles facing the implementation of a molecular screening program in an early drug development unit: The Jules Bordet Institute Program for Molecular Profiling of Metastatic Lesions - feasibility (Precision-f)
by Aftimos, Philippe G and Maetens, Marion and Sibille, Catherine and Laes, Jean-François and Brohée, Sylvain and Berghmans, Thierry and Kerger, Joseph and Hendlisz, Alain and Irrthum, Alexandre and De Henau, Olivier and Deleporte, Amélie and Drisis, Stylianos and Larsimont, Denis and Vakili, Jalal and Sotiriou, Christos and Piccart, Martine and Awada, Ahmad
Cancer research (Chicago, Ill.), ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 3891 - 3891
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14. Full Text The Chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo
by Bondue, Benjamin and de Henau, Olivier and Luangsay, Souphalone and Devosse, Thalie and de Nadaï, Patricia and Springael, Jean-Yves and Parmentier, Marc and Vosters, Olivier
PloS one, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e40043 - e40043
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | Receptors, G-Protein-Coupled - metabolism | Humans | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Macrophages, Peritoneal - pathology | Male | Intercellular Signaling Peptides and Proteins - metabolism | Microspheres | Animals | Chemotactic Factors - metabolism | Thioglycolates | Inflammation Mediators - metabolism | Lipopolysaccharides - pharmacology | Acrylic Resins | Chemokines - metabolism | Mice | Macrophage Activation - drug effects | Macrophages, Peritoneal - metabolism | Macrophages, Peritoneal - drug effects | Cytokines - biosynthesis | Macrophages | Tumor necrosis factor | Enzyme-linked immunosorbent assay | Membrane proteins | Flow cytometry | Inflammatory response | Innate immunity | Adipocytes | Metabolic syndrome | Immunity | Experiments | Lipopolysaccharides | Interleukin 6 | Peripheral blood | Cytokines | Dendritic cells | Neutrophils | Inflammation | Tumor necrosis factor-α | Chemotaxis | Cytometry | Monocytes | γ-Interferon | Interleukin 10 | Interferon | Beads | Peritoneum | Index Medicus
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15. Full Text The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy
by Khalil, Danny N and Budhu, Sadna and Gasmi, Billel and Zappasodi, Roberta and Hirschhorn-Cymerman, Daniel and Plitt, Tamar and De Henau, Olivier and Zamarin, Dmitriy and Holmgaard, Rikke B and Murphy, Judith T and Wolchok, Jedd D and Merghoub, Taha
Advances in Cancer Research, ISSN 0065-230X, 2015, Volume 128, pp. 1 - 68
CAR T cells | Adoptive cell therapy | Costimulation | Checkpoint blockade | Immunotherapy | Neoplasms - therapy | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Neoplasms - immunology | T-Lymphocytes - drug effects | Humans | T-Lymphocytes - immunology | Antineoplastic Agents - therapeutic use | Index Medicus
Conference Proceeding
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16. Full Text Abstract B032: The PI3K-γ inhibitor, IPI-549, increases antitumor immunity by targeting tumor-associated myeloid cells and remodeling the immune-suppressive tumor microenvironment
by Rausch, Matthew and Tchaicha, Jeremy and Tibbitts, Thomas and Henau, Olivier De and Sharma, Sujata and Pink, Melissa and Gladstone, Joseph and Proctor, Jennifer and Douglas, Mark and Stern, Howard and Merghoub, Taha and Wolchok, Jedd and McGovern, Karen and Kutok, Jeff and Winkler, David
Cancer immunology research, ISSN 2326-6066, 11/2016, Volume 4, Issue 11 Supplement, pp. B032 - B032
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17. Full Text Trends in net survival from rectal cancer in six European Latin countries: Results from the SUDCAN population-based study
by Lepage, Côme and Bossard, Nadine and Dejardin, Olivier and Carmona-Garcia, Maria C and Manfredi, Sylvain and Faivre, Jean and Van Eycken, E and Henau, K and Velten, M and Bouvier, V and Launoy, G and Bouvier, A.M and Woronoff, A.S and Robaszkiewicz, M and Tretarre, B and Uhry, Z and Colonna, M and Molinié, F and Bara, S and Lapôtre-Ledoux, B and Grosclaude, P and Brenner, H and Katalinic, A and Mazzoleni, G and Bulatko, A and Buzzoni, C and Giacomin, A and Ferretti, S and Barchielli, A and Manneschi, G and Gatta, G and Sant, M and Amash, H and Amati, C and Baili, P and Berrino, F and Bonfarnuzzo, S and Botta, L and Capocaccia, R and Di Salvo, F and Foschi, R and Margutti, C and Meneghini, E and Minicozzi, P and Trama, A and Serraino, D and Zucchetto, A and De Angelis, R and Caldora, M and Carrani, E and Francisci, S and Mallone, S and Pierannunzio, D and Roazzi, P and Rossi, S and Santaquilani, M and Tavilla, A and Pannozzo, F and Natali, M and Filiberti, R.A and Vercelli, M and Ricci, P and Autelitano, M and Randi, G and Ponz De Leon, M and Spagnoli, G and Cirilli, C and Fusco, M and Vitale, M.F and Michiara, M and Tumino, R and Mangone, L and Di Felice, E and Falcini, F and Iannelli, A and Sechi, O and Cesaraccio, R and Piffer, S and Madeddu, A and Tisano, F and Maspero, S and Fanetti, A.C and Zanetti, R and Rosso, S and Stracci, F and Rocca, A and Tagliabue, G and Contiero, P and Rugge, M and Guzzinati, S and Bielska-Lasota, M and Bento, M.J and Castro, C and Miranda, A and Mayer-Da-silva, A and Primic-Zakelj, M and Almar, E and Mateos, A and Errezola, M and Larrañaga, N and ... and GRELL EUROCARE-5 Working Grp and GRELL EUROCARE-5 Working Group
European journal of cancer prevention, ISSN 0959-8278, 2017, Volume 26, pp. S48 - S55
Cancer registries | Net survival | Excess mortality rates | Rectal cancer | Trends analysis | Europe | Life Sciences & Biomedicine | Oncology | Science & Technology | Rectal Neoplasms - diagnosis | France - epidemiology | Survival Rate - trends | Belgium - epidemiology | Humans | Middle Aged | Europe - epidemiology | Male | Rectal Neoplasms - mortality | Young Adult | Spain - epidemiology | Switzerland - epidemiology | Adolescent | Portugal - epidemiology | Aged, 80 and over | Adult | Female | Italy - epidemiology | Registries | Aged | Databases, Factual - trends | Population Surveillance - methods | Index Medicus
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