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Investigational New Drugs, ISSN 0167-6997, 10/2018, Volume 36, Issue 5, pp. 828 - 835
Purpose This phase 1 study examined safety, pharmacokinetics (PK), and efficacy of the poly(ADP-ribose) polymerase (PARP) inhibitor ABT-767 in patients with... 
BRCA | Solid tumor | Medicine & Public Health | PARP inhibitor | Oncology | Pharmacology/Toxicology | Homologous recombination deficiency | Ovarian cancer | POLY(ADP-RIBOSE) POLYMERASE | ONCOLOGY | PHARMACOLOGY & PHARMACY | EPITHELIAL OVARIAN | Nausea - chemically induced | Benzamides - pharmacokinetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Fatigue - chemically induced | Ovarian Neoplasms - genetics | Peritoneal Neoplasms - drug therapy | Benzamides - therapeutic use | Fallopian Tube Neoplasms - genetics | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Ovarian Neoplasms - drug therapy | Fallopian Tube Neoplasms - drug therapy | Food-Drug Interactions | Poly(ADP-ribose) Polymerase Inhibitors - pharmacokinetics | Anemia - chemically induced | Treatment Outcome | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Sulfonamides - pharmacokinetics | BRCA1 Protein - genetics | Maximum Tolerated Dose | Sulfonamides - therapeutic use | Peritoneal Neoplasms - genetics | Aged | Mutation | BRCA2 Protein - genetics | Antimitotic agents | Genetic aspects | Research | Drug therapy | Antineoplastic agents | Slopes | Ovarian carcinoma | Toxicity | Homologous recombination | Poly(ADP-ribose) | Homology | Fallopian tube | Dosage | ADP | Platinum | Ribose | Bioindicators | Toxic diseases | Safety | BRCA2 protein | Appetite | BRCA1 protein | Anemia | Poly(ADP-ribose) polymerase | Fatigue | Radioactive half-life | Nausea | Breast cancer | Pharmacology | Bioavailability | Patients | Polymerase | Sensitivity | Inhibitors | Response rates | Biomarkers | Solid tumors | Pharmacokinetics | Tumors | Peritoneum | Cancer | Index Medicus | Phase I Studies
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Psycho-Oncology, ISSN 1057-9249, 01/2018, Volume 27, Issue 1, pp. i - i
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Journal of Clinical Oncology, ISSN 0732-183X, 06/2007, Volume 25, Issue 17, pp. 2340 - 2342
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Investigational New Drugs, ISSN 0167-6997, 8/2014, Volume 32, Issue 4, pp. 670 - 681
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European Journal of Cancer, ISSN 0959-8049, 2008, Volume 44, Issue 4, pp. 486 - 487
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Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 3013 - 3013
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PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0149405 - e0149405
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2017, Volume 76, pp. 144 - 151
Abstract Purpose In tumours with wild-type TP53 , the tumour-suppressive function of p53 is frequently inhibited by HDM2. This phase I, dose-escalating study... 
Hematology, Oncology and Palliative Medicine | HDM2 | De-differentiated liposarcoma | Pharmacodynamics | Solid tumours | MDM2 | Pharmacokinetics | SAR405838 | p53 | LIPOSARCOMA | P53 PATHWAY | TRIAL | AMPLIFICATION | DATABASE | ONCOLOGY | MDM2 ANTAGONIST | MUTATION | INHIBITOR | Lung Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Nausea - chemically induced | Gastrointestinal Neoplasms - drug therapy | Humans | Middle Aged | Spiro Compounds - administration & dosage | Lung Neoplasms - pathology | Male | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Spiro Compounds - adverse effects | Indoles - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Gastrointestinal Neoplasms - pathology | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Skin Neoplasms - pathology | Liposarcoma - drug therapy | Liposarcoma - pathology | Thrombocytopenia - chemically induced | Melanoma - pathology | Spiro Compounds - pharmacokinetics | Neoplasms - drug therapy | Vomiting - chemically induced | Maximum Tolerated Dose | Indoles - adverse effects | Melanoma - drug therapy | Anorexia - chemically induced | Indoles - pharmacokinetics | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasms - pathology | Tumor proteins | Care and treatment | Tumors | Cytokines | Toxicity | p53 Protein | Nausea | Pharmacology | Patients | Metastases | Minimum inhibitory concentration | Liposarcoma | Biomarkers | Bioindicators | Safety | Solid tumors | Mutation | Index Medicus
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