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Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1239 - 1247
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, pp. 8399 - 8399
Journal Article
Journal Article
Powder Technology, ISSN 0032-5910, 07/2015, Volume 278, pp. 26 - 34
Designing more efficient excavating equipment in bulk handling is a complex task as accurate analytical models for the interaction between bulk material and... 
Excavating | Scale factor | Particle scaling | Equipment scaling | Scaling laws | ENGINEERING, CHEMICAL | DESIGN | SILO CENTRIFUGE | MODEL | FLOW | COHESIVE BULK SOLIDS | Excavating machinery | Analysis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2010, Volume 285, Issue 38, pp. 29111 - 29127
Journal Article
Molecular Cancer, ISSN 1476-4598, 09/2011, Volume 10, Issue 1, pp. 111 - 111
Background: In around 50% of all human cancers the tumor suppressor p53 is mutated. It is generally assumed that in the remaining tumors the wild-type p53... 
HMDMX | Nutlin-3 | Transformation model | Tumorigenesis | Retinoblastoma | HMDM2 | P53 pathway | WILD-TYPE P53 | ACTIVATION | PROTEIN | p53 pathway | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVEREXPRESSION | REGULATOR | ONCOLOGY | retinoblastoma | PATHWAY | hMDMX | MDM2 | hMDM2 | DEGRADATION | tumorigenesis | HUMAN TUMOR-CELLS | P53-MEDIATED TRANSACTIVATION | Neoplasm Transplantation | Retina - metabolism | Cell Proliferation | Humans | Piperazines - metabolism | Gene Expression Profiling | Retina - embryology | Chorioallantoic Membrane - pathology | Cell Shape | Oncogenes | Fibroblasts - metabolism | Imidazoles - metabolism | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Gene Expression | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Fibroblasts - pathology | Mice, SCID | Cell Adhesion | Cell Transformation, Neoplastic - metabolism | Chick Embryo | Retinoblastoma - metabolism | Animals | Mice, Nude | Mice | Mice, Inbred BALB C | Primary Cell Culture | Cell Transformation, Neoplastic - pathology | Retina - pathology | Gene mutations | Fibroblasts | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Cancer | Flow cytometry | Gene amplification | Cell cycle | Telomerase | Chromosomes | DNA repair | Tumors | Index Medicus
Journal Article
AMERICAN JOURNAL OF CANCER RESEARCH, ISSN 2156-6976, 2012, Volume 2, Issue 5, pp. 492 - 507
The p53 tumor suppressor pathway is inactivated in cancer either via direct mutation or via deregulation of upstream regulators or downstream effectors. P53... 
Nutlin-3 | XI-011 | p27 | ONCOLOGY | Hdmx | retinoblastoma | Uveal melanoma | SAH-p53-8 | p53
Journal Article
Journal of Organizational Behavior, ISSN 0894-3796, 2010, Volume 31, pp. 1111 - 1136
Research on the association between high commitment Human Resource (HR) practices and work-related outcomes at the individual level rarely focuses on age... 
Journal Article
Journal of Organizational Behavior, ISSN 0894-3796, 2010, Volume 31, Issue 8, pp. 1111 - 1136
Journal Article
Journal of Organizational Behavior, ISSN 0894-3796, 11/2010, Volume 31, Issue 8, pp. 1111 - 1136
Research on the association between high commitment Human Resource (HR) practices and work-related outcomes at the individual level rarely focuses on age... 
Journal Article
Psicothema, ISSN 0214-9915, 2012, Volume 24, Issue 1, pp. 87 - 93
Journal Article
Journal of Sleep Research, ISSN 0962-1105, 2009, Volume 18, Issue 3, p. 374
Summary This prospective four-wave study examined (i) the causal direction of the longitudinal relations among job demands, job control, sleep quality and... 
Journal Article
Australian Accounting Review, ISSN 1035-6908, 11/2006, Volume 16, Issue 40, pp. 52 - 59
The introduction of the goods and services tax in Australia saw a fundamental shift in the working conditions and type of work performed by public accounting... 
Studies | GST | Accountants | Job satisfaction | Burnout | Stress
Journal Article