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Xenobiotica, ISSN 0049-8254, 09/2017, Volume 47, Issue 9, pp. 825 - 832
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2019, Volume 108, Issue 9, pp. 3118 - 3123
Cobicistat has been reported to increase serum creatinine clinically without affecting glomerular filtration. This was ascribed to transient inhibition of... 
renal transport | membrane transporter(s) | multidrug and toxic compound extrusion transporter (MATE) | active transport | organic cation transporter(s) (OCT)
Journal Article
Xenobiotica; the fate of foreign compounds in biological systems, 09/2017, Volume 47, Issue 9, p. 825
1. Accurate predictions of clinical transporter-mediated drug-drug interactions (DDI) from in vitro data can be challenging when compounds have poor solubility... 
Drug Interactions | Humans | Inhibitory Concentration 50 | Membrane Transport Proteins - metabolism | Organic Anion Transporters - metabolism
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2013, Volume 41, Issue 12, pp. 2012 - 2017
P-glycoprotein (P-gp) is expressed at the blood-brain barrier (BBB) and restricts the penetration of its substrates into the central nervous system (CNS). In... 
SILICO PREDICTION | TRANSPORT | IMPACT | BARRIER PERMEATION | PLASMA | CNS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | BINDING | Brain - metabolism | Animals | Biopharmaceutics - methods | Humans | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Central Nervous System Agents - metabolism | Permeability | Blood-Brain Barrier - metabolism
Journal Article
Experimental Biology and Medicine, ISSN 1535-3702, 10/2017, Volume 242, Issue 16, pp. 1579 - 1585
Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human physiology, these chips have the potential to increase the predictive... 
innovation | toxicology | pharmacokinetics | partnership | microphysiological systems | Tissue chips | MEDICINE, RESEARCH & EXPERIMENTAL | Drug Evaluation, Preclinical - methods | Lab-On-A-Chip Devices | Microchip Analytical Procedures - methods | Microfluidics - methods | Drug Industry | Humans
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Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2017, Volume 32, Issue 1, pp. S51 - S51
Journal Article
Journal Article
Xenobiotica, ISSN 0049-8254, 09/2017, Volume 47, Issue 9, pp. 825 - 832
1. Accurate predictions of clinical transporter-mediated drug-drug interactions (DDI) from in vitro data can be challenging when compounds have poor solubility... 
total IC | Albumin | DDI | drug-drug interactions | transporters | values | drug–drug interactions | HIV INTEGRASE INHIBITOR | HUMAN PLASMA | PROTEIN-BINDING | DOLUTEGRAVIR | RENAL TRANSPORTERS | SLCO1B3 GENE | HYPERBILIRUBINEMIA | PHARMACOKINETICS | total IC50 values | PHARMACOLOGY & PHARMACY | TOXICOLOGY
Journal Article
Combinatorial Chemistry & High Throughput Screening, ISSN 1386-2073, 06/2015, Volume 18, Issue 5, pp. 442 - 452
A high throughput, semi-automated clearance screening assay in hepatocytes was developed allowing a scientist to generate data for 96 compounds in one week.... 
Journal Article