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Journal of the National Cancer Institute, ISSN 0027-8874, 11/2004, Volume 96, Issue 21, pp. 1620 - 1630
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 11/2013, Volume 93, Issue 5, pp. 967 - 975
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0125898
Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene... 
THERAPY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | STIRIPENTOL | SEVERE MYOCLONIC EPILEPSY | CHANNELS | FEBRILE SEIZURES | EXPRESSION | INFANCY | INTERNEURONS | CHILDREN | Fenfluramine - therapeutic use | Zebrafish Proteins - metabolism | Humans | NAV1.1 Voltage-Gated Sodium Channel - genetics | Oligonucleotides, Antisense - metabolism | Serotonin Uptake Inhibitors - therapeutic use | Anticonvulsants - therapeutic use | Anticonvulsants - administration & dosage | Zebrafish | Epilepsies, Myoclonic - pathology | NAV1.1 Voltage-Gated Sodium Channel - metabolism | Gene Knockdown Techniques | Morpholinos - metabolism | Animals | Valproic Acid - administration & dosage | Serotonin Uptake Inhibitors - administration & dosage | Fenfluramine - administration & dosage | Valproic Acid - therapeutic use | Epilepsies, Myoclonic - drug therapy | Zebrafish Proteins - genetics | Disease Models, Animal | Epilepsies, Myoclonic - genetics | Genetic aspects | Research | Gene mutations | Drug therapy | Epilepsy in children | Neuroimaging | Drugs | Brain | Larvae | Neurosciences | Animal models | Laboratories | Hyperactivity | Epilepsy | Genes | Forebrain | Clinical trials | Antisense | Fenfluramine | Genomes | Posture | Oligomers | Electrophysiological recording | Genotype & phenotype | Convulsions & seizures | Sodium channels (voltage-gated) | Behavior | Inhibition | Children | Drug dosages | Seizures | Seizing | Medical research | Image resolution | Firing pattern | Serotonin | Pharmacology | Valproic acid | Patients | Discharge | Neurology | Side effects | Sodium | Sodium valproate | Mutation | Hyperthermia | Pharmaceuticals
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e14694
Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. The identification of lead compounds of... 
VASCULAR DEVELOPMENT | GENETIC APPROACH | TRANSGENIC ZEBRAFISH | CELLS | EMODIN | MULTIDISCIPLINARY SCIENCES | PROTEIN-KINASE CK2 | IN-VIVO | DRUG DISCOVERY | GROWTH | NEOVASCULARIZATION | Africa, Eastern | Neovascularization, Physiologic - drug effects | Plant Extracts - chemistry | Plant Extracts - pharmacology | Drug Discovery - methods | Biological Products - pharmacology | Green Fluorescent Proteins - genetics | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | Green Fluorescent Proteins - metabolism | Plants, Medicinal - chemistry | Emodin - pharmacology | Animals, Genetically Modified | Embryo, Nonmammalian - blood supply | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Biological Assay - methods | Chick Embryo | Biological Products - isolation & purification | Neovascularization, Physiologic - physiology | Diterpenes, Abietane - pharmacology | Animals | Models, Biological | Coleus - chemistry | Zebrafish - physiology | Angiogenesis Inhibitors - isolation & purification | Medicinal plants | Biological products | Medicine, Botanic | Genetic engineering | Medicine, Herbal | Drug discovery | Angiogenesis inhibitors | Product introduction | Mass spectrometry | Chromatography | Cell proliferation | Protein kinase C | Leukocyte migration | Laboratories | Identification methods | Genomics | Transgenic plants | Casein kinase II | Regulatory approval | FLI-1 protein | Angiogenesis | Inhibition | Pharmaceutical sciences | Plants (botany) | Medical research | Fractionation | Bioassay | Research & development--R&D | Bioassays | Cell division | Zebrafish | Mass spectroscopy | Lead compounds | Biological assays | Embryos | Biological activity | Endothelial cells | Plant extracts | Emodin | Herbal medicine | Screening | Thin layer chromatography | Flavonoids | Chorioallantoic membrane | Natural products | Thin-layer chromatography | Mutation | Cell migration | Cancer | Research & development | R&D
Journal Article
Current Biology, ISSN 0960-9822, 06/2018, Volume 28, Issue 12, pp. 1924 - 1937.e5
Mutations in are causal factors for a broad spectrum of focal epilepsies, but the underlying pathogenic mechanisms are still largely unknown. To address this... 
epilepsy | GABA | mTOR | zebrafish | neurodevelopment | DEPDC5 | MAMMALIAN TARGET | RAPAMYCIN | DOMINANT FOCAL EPILEPSIES | CORTICAL DYSPLASIA | LYMPHANGIOLEIOMYOMATOSIS | TUBEROUS SCLEROSIS COMPLEX | GENE | TRANSFER-RNA SYNTHETASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VARIABLE FOCI | MUTATIONS | CELL BIOLOGY | Seizures (Medicine) | Neurons | Analysis | Epilepsy | Life Sciences
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, pp. 37145 - 37145
Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is... 
DANIO-RERIO | PROTEIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ENDOTHELIAL-CELLS | LIVER | IDENTIFICATION | TITANIUM-DIOXIDE NANOPARTICLES | SILVER NANOPARTICLES | BRAIN | EMBRYOS | Nanoparticles | Neurotoxicity | Hatching | Toxicity | Attention | Nanomaterials | Zebrafish | Embryos | Hepatotoxicity | Silica | Nanotechnology | Index Medicus
Journal Article