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1. Full Text The recursive trek of epigenetics from the bench to the bedside predictive methylation marks by the Dozen
by DeMeo, Dawn L
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2018, Volume 198, Issue 2, pp. 145 - 146
In a study presented in this issue of the Journal, Leng and colleagues (pp. 187-196) used a nested methylation-specific PCR approach to investigate whether a... 
RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE | Studies | Smoking cessation | Lung cancer | Mortality | Genes | DNA methylation | Biomarkers | Epigenetics | Genomes | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA
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2. Full Text DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
by Joubert, Bonnie R and Felix, Janine F and Yousefi, Paul and Bakulski, Kelly M and Just, Allan C and Breton, Carrie and Reese, Sarah E and Markunas, Christina A and Richmond, Rebecca C and Xu, Cheng-Jian and Xu, Zongli and Küpers, Leanne K and Oh, Sam S and Hoyo, Cathrine and Gruzieva, Olena and Söderhäll, Cilla and Salas, Lucas A and Baïz, Nour and Zhang, Hongmei and Lepeule, Johanna and Ruiz, Carlos and Ligthart, Symen and Wang, Tianyuan and Taylor, Jack A and Duijts, Liesbeth and Sharp, Gemma C and Jankipersadsing, Soesma A and Nilsen, Roy M and Vaez, Ahmad and Fallin, M. Daniele and Hu, Donglei and Litonjua, Augusto A and Fuemmeler, Bernard F and Huen, Karen and Kere, Juha and Kull, Inger and Munthe-Kaas, Monica Cheng and Gehring, Ulrike and Bustamante, Mariona and Saurel-Coubizolles, Marie José and Quraishi, Bilal M and Ren, Jie and Tost, Jörg and Gonzalez, Juan R and Peters, Marjolein J and Håberg, Siri E and van Meurs, Joyce B and Gaunt, Tom R and Kerkhof, Marjan and Corpeleijn, Eva and Feinberg, Andrew P and Eng, Celeste and Baccarelli, Andrea A and Benjamin Neelon, Sara E and Bradman, Asa and Merid, Simon Kebede and Bergström, Anna and Herceg, Zdenko and Hernandez-Vargas, Hector and Brunekreef, Bert and Pinart, Mariona and Heude, Barbara and Ewart, Susan and Yao, Jin and Lemonnier, Nathanaël and Franco, Oscar H and Wu, Michael C and Hofman, Albert and McArdle, Wendy and Van der Vlies, Pieter and Falahi, Fahimeh and Gillman, Matthew W and Barcellos, Lisa F and Kumar, Ashish and Wickman, Magnus and Guerra, Stefano and Charles, Marie-Aline and Holloway, John and Auffray, Charles and Tiemeier, Henning W and Smith, George Davey and Postma, Dirkje and Hivert, Marie-France and Eskenazi, Brenda and Vrijheid, Martine and Arshad, Hasan and Antó, Josep M and Dehghan, Abbas and Karmaus, Wilfried and Annesi-Maesano, Isabella and Sunyer, Jordi and Ghantous, Akram and Pershagen, Göran and Holland, Nina and Murphy, Susan K and DeMeo, Dawn L and Burchard, Esteban G and Ladd-Acosta, Christine and Snieder, Harold and Nystad, Wenche and ...
The American Journal of Human Genetics, ISSN 0002-9297, 04/2016, Volume 98, Issue 4, pp. 680 - 696
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy... 
BREAST-CANCER | IN-UTERO | CIGARETTE-SMOKING | LYMPH-NODE METASTASIS | PRENATAL EXPOSURE | TOBACCO-SMOKING | GENETICS & HEREDITY | LUNG-FUNCTION DECLINE | NEUROPILIN-2 EXPRESSION | AUTISM SPECTRUM DISORDERS | POSTSYNAPTIC DENSITY | Smoking - adverse effects | European Continental Ancestry Group - genetics | Genetic Association Studies | Epigenesis, Genetic | Humans | Child, Preschool | Infant | Chromosome Mapping | Cleft Palate - genetics | Asthma - genetics | Pregnancy | Cleft Lip - genetics | DNA Methylation | Cleft Palate - etiology | Female | Asthma - etiology | Child | Infant, Newborn | Cleft Lip - etiology | Genome-wide association studies | Genetic aspects | Nucleotide sequencing | Methylation | Health aspects | Methods | DNA sequencing | Smoking
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3. Full Text Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency
by Kim, Woo Jin and Wood, Alice M and Barker, Alan F and Brantly, Mark L and Campbell, Edward J and Eden, Edward and McElvaney, Gerard and Rennard, Stephen I and Sandhaus, Robert A and Stocks, James M and Stoller, James K and Strange, Charlie and Turino, Gerard and Silverman, Edwin K and Stockley, Robert A and DeMeo, Dawn L
Respiratory Research, ISSN 1465-9921, 02/2012, Volume 13, Issue 1, pp. 16 - 16
Background: The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association... 
Genetic modifiers | CHRNA3 | Chronic obstructive pulmonary disease | Genetic association analysis | IREB2 | ALPHA-ANTITRYPSIN DEFICIENCY | LUNG-FUNCTION | RECEPTOR | CANCER | NICOTINE DEPENDENCE | IRON-METABOLISM | GENE | RESPIRATORY SYSTEM | SUSCEPTIBILITY LOCUS | PULMONARY-DISEASE | GENOME-WIDE ASSOCIATION | Severity of Illness Index | alpha 1-Antitrypsin Deficiency - genetics | Pulmonary Emphysema - physiopathology | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Chromosomes, Human, Pair 15 - genetics | Iron Regulatory Protein 2 - genetics | Pulmonary Emphysema - genetics | Sex Factors | alpha 1-Antitrypsin Deficiency - physiopathology | Adult | Female | Polymorphism, Single Nucleotide | Respiratory Function Tests | Receptors, Nicotinic - genetics | Lung diseases, Obstructive | Genetic aspects | Pulmonary function tests | Research | Analysis | Genetic polymorphisms | Genes | Single nucleotide polymorphisms | Cigarettes | Protein binding | Smoking | Studies | Fees & charges | Hospitals | Meetings | Genetics | Genomes | Gene expression | Charitable foundations
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4. Full Text Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva
by Tian, Fu-Ying and Rifas-Shiman, Sheryl L and Cardenas, Andres and Baccarelli, Andrea A and DeMeo, Dawn L and Litonjua, Augusto A and Rich-Edwards, Janet W and Gillman, Matthew W and Oken, Emily and Hivert, Marie-France
International Journal of Obesity, ISSN 0307-0565, 2018, Volume 43, Issue 6, pp. 1244 - 1255
Corticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses... 
Corticotropin releasing hormone | Analysis | Risk assessment | Children | Research | Gene expression | Methylation | Health aspects | LEP gene | Neonates | Hormones | Hydrocortisone | Blood | Gestational age | Body mass index | Cord blood | DNA methylation | Prenatal experience | Deoxyribonucleic acid--DNA | Age | CpG islands | Secretion | Fetuses | Blood cells | Regional analysis | Health risks | Minority & ethnic groups | Corticotropin-releasing hormone | Biological activity | Blood levels | Pregnancy | Body mass | Body size | Umbilical cord | Smoking | corticotropin-releasing hormone | cord blood | childhood | LEP
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5. Full Text New Statistical Methods for Constructing Robust Differential Correlation Networks to characterize the interactions among microRNAs
by Yu, Danyang and Zhang, Zeyu and Glass, Kimberly and Su, Jessica and DeMeo, Dawn L and Tantisira, Kelan and Weiss, Scott T and Qiu, Weiliang
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 3499 - 12
The interplay among microRNAs (miRNAs) plays an important role in the developments of complex human diseases. Co-expression networks can characterize the... 
CELLS | MULTIDISCIPLINARY SCIENCES | DISCOVERY | Data processing | Transformation | MicroRNAs | MiRNA
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6. Full Text Transmission of Lymphocytic Choriomeningitis Virus by Organ Transplantation
by Fischer, Staci A and Graham, Mary Beth and Kuehnert, Matthew J and Kotton, Camille N and Srinivasan, Arjun and Marty, Francisco M and Comer, James A and Guarner, Jeannette and Paddock, Christopher D and DeMeo, Dawn L and Shieh, Wun-Ju and Erickson, Bobbie R and Bandy, Utpala and DeMaria, Alfred and Davis, Jeffrey P and Delmonico, Francis L and Pavlin, Boris and Likos, Anna and Vincent, Martin J and Sealy, Tara K and Goldsmith, Cynthia S and Jernigan, Daniel B and Rollin, Pierre E and Packard, Michelle M and Patel, Mitesh and Rowland, Courtney and Helfand, Rita F and Nichol, Stuart T and Fishman, Jay A and Ksiazek, Thomas and Zaki, Sherif R and the LCMV in Transplant Recipients Investigation Team and LCMV Transplant Recipient and LCMV in Transplant Recipients Investigation Team
The New England Journal of Medicine, ISSN 0028-4793, 05/2006, Volume 354, Issue 21, pp. 2235 - 2249
This report documents two clusters of lymphocytic choriomeningitis virus (LCMV) infection transmitted through solid-organ transplantation. Seven of the eight... 
ANIMALS | MENINGITIS | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | PERSONNEL | DISEASE | INFECTION | MENINGOENCEPHALITIS | PET HAMSTER | OUTBREAK | RECIPIENTS | Liver - virology | Cricetinae | Liver - pathology | Lung - pathology | Kidney - pathology | Humans | Middle Aged | Male | Lymphocytic choriomeningitis virus - ultrastructure | Microscopy, Electron | Lymphocytic choriomeningitis virus - classification | Lymphocytic Choriomeningitis - transmission | Zoonoses - transmission | Lymphocytic choriomeningitis virus - isolation & purification | Lung - virology | Animals | Arenaviridae Infections - veterinary | Organ Transplantation - adverse effects | Fatal Outcome | Adult | Female | Disease Transmission, Infectious | Kidney - virology | Viral meningitis | Disease transmission | Causes of | Transplantation of organs, tissues, etc | Diagnosis | Health aspects | Risk factors | Cytomegalovirus | Nuclear magnetic resonance--NMR | Transplants & implants | Diarrhea | Infections | Medical diagnosis | Viral infections | Fever
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7. Full Text The value of blood cytokines and chemokines in assessing COPD
by Bradford, Eric and Jacobson, Sean and Varasteh, Jason and Comellas, Alejandro P and Woodruff, Prescott and O'Neal, Wanda and DeMeo, Dawn L and Li, Xingnan and Kim, Victor and Cho, Michael and Castaldi, Peter J and Hersh, Craig and Silverman, Edwin K and Crapo, James D and Kechris, Katerina and Bowler, Russell P
Respiratory research, ISSN 1465-993X, 10/2017, Volume 18, Issue 1, pp. 180 - 11
Background: Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer... 
C-REACTIVE PROTEIN | SYSTEMIC INFLAMMATION | OBSTRUCTIVE PULMONARY-DISEASE | SURFACTANT PROTEIN-D | PLASMA-FIBRINOGEN | BIOMARKER | RESPIRATORY SYSTEM | AIRWAY INFLAMMATION | EXACERBATIONS | SERUM | SOLUBLE RECEPTOR | Pulmonary Disease, Chronic Obstructive - diagnosis | Chemokines - blood | Prospective Studies | Smoking - blood | Humans | Middle Aged | Male | Biomarkers - blood | Pulmonary Disease, Chronic Obstructive - epidemiology | Smoking - epidemiology | Pulmonary Disease, Chronic Obstructive - blood | Aged, 80 and over | Female | Aged | Cohort Studies | Cytokines - blood | Lung diseases, Obstructive | Care and treatment | Cytokines | Physiological aspects | Development and progression | Genetic aspects | Diagnosis | Research | Chemokines | Plasma | Systemic diseases | Interleukin | Genomes | Single-nucleotide polymorphism | Blood | Eotaxin | Proteins | Interleukin 6 | Airway management | Regression models | Interleukin 2 | Chronic obstructive pulmonary disease | Bronchitis | CCL17 protein | Interleukin 8 | Subpopulations | Phenotypes | Lung diseases | Health risks | Inflammation | Regression analysis | Tumor necrosis factor-α | Tobacco | Air flow | Biopsy | γ-Interferon | Obstructive lung disease | Interleukin 10 | Biomarkers | Interferon | Emphysema | Smoking
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8. Full Text A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data
by Li, Xuan and Qiu, Weiliang and Morrow, Jarrett and DeMeo, Dawn L and Weiss, Scott T and Fu, Yuejiao and Wang, Xiaogang
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145295
Variable DNA methylation has been associated with cancers and complex diseases. Researchers have identified many DNA methylation markers that have different... 
CELLS | RISK | DIFFERENTIAL VARIABILITY | EPIGENETIC VARIATION | CANCER | MULTIDISCIPLINARY SCIENCES | DNA Methylation | Analysis of Variance | Computer Simulation | Humans | CpG Islands | Models, Genetic | Genetic Markers | Case-Control Studies | Genetic markers | Usage | Physiological aspects | Genetic aspects | Research | Methylation | Genetic screening | Disease | Mathematics | Genomes | Statistical methods | Variance | Medical schools | Biological effects | DNA methylation | Equality | Bioinformatics | Deoxyribonucleic acid--DNA | Medical research | Data analysis | Statistical analysis | Markers | Data processing | Gene expression | Medicine | Studies | Hospitals | Researchers | Simulation | Womens health | Epigenetics | Homogeneity | Cancer | Deoxyribonucleic acid | DNA
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9. Full Text Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function
by Qiu, Weiliang and Baccarelli, Andrea and Carey, Vincent J and Boutaoui, Nadia and Bacherman, Helene and Klanderman, Barbara and Rennard, Stephen and Agusti, Alvar and Anderson, Wayne and Lomas, David A and DeMeo, Dawn L
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2012, Volume 185, Issue 4, pp. 373 - 381
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with local (lung) and systemic (blood) inflammation and manifestations. DNA methylation... 
DNA methylation | Epigenetics | Chronic obstructive pulmonary disease | Smoking | HYPERMETHYLATION | BIOMARKER | ADHESION MOLECULES | CANCER | epigenetics | ABERRANT PROMOTER METHYLATION | MULTIPLE GENES | K-RAS | EPITHELIUM | RESPIRATORY SYSTEM | smoking | EXPRESSION | chronic obstructive pulmonary disease | CRITICAL CARE MEDICINE | Smoking - adverse effects | Genetic Predisposition to Disease | alpha 1-Antitrypsin - genetics | Oligonucleotide Array Sequence Analysis | Epigenesis, Genetic | Humans | Middle Aged | Linear Models | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Genetic Markers | Forced Expiratory Volume | Vital Capacity | DNA Methylation | Phenotype | CpG Islands - genetics | Female | Cohort Studies | Pulmonary Disease, Chronic Obstructive - genetics
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10. Full Text Regulatory network changes between cell lines and their tissues of origin
by Lopes-Ramos, Camila M and Paulson, Joseph N and Chen, Cho-Yi and Kuijjer, Marieke L and Fagny, Maud and Platig, John and Sonawane, Abhijeet R and DeMeo, Dawn L and Quackenbush, John and Glass, Kimberly
BMC Genomics, ISSN 1471-2164, 09/2017, Volume 18, Issue 1, pp. 1 - 13
Background: Cell lines are an indispensable tool in biomedical research and often used as surrogates for tissues. Although there are recognized important... 
GTEx | Regulatory networks | Fibroblast cell lines | Lymphoblastoid cell lines | Transcriptome | TRANSFORMATION | USF | PROLIFERATION | IDENTIFICATION | SUPPRESSION | FAMILY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | DYNAMICS | REPRESSOR | E2F8 | Transcription factors | Research | Gene expression | Cell lines | Smad5 protein | Cell culture | Biotechnology | Gene regulation | Viruses | Principal components analysis | Genomes | Tissues | Ribonucleic acid--RNA | Biopsy | Network analysis | Cell cycle | Regulatory mechanisms (biology) | Fibroblasts | Skin
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11. Full Text The nasal methylome as a biomarker of asthma and airway inflammation in children
by Cardenas, A and Sordillo, JE and Rifas-Shiman, SL and Chung, W and Liang, LM and Coull, BA and Hivert, MF and Lai, PS and Forno, E and Celedon, JC and Litonjua, AA and Brennan, KJ and DeMeo, DL and Baccarelli, AA and Oken, E and Gold, DR
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3095 - 10
The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547... 
SERUM IMMUNOGLOBULIN-E | LUNG | DNA METHYLATION | EPITHELIAL-CELLS | EOSINOPHILS | MULTIDISCIPLINARY SCIENCES | CELL-TYPE HETEROGENEITY | RISK | EXHALED NITRIC-OXIDE | EPIGENOME-WIDE ASSOCIATION | CHILDHOOD ASTHMA | Allergens | Respiratory function | Rhinitis | Genes | Immunoglobulin E | Allergic diseases | Lymphocytes T | Interleukin 4 | Cell activation | Allergic rhinitis | Nose | Interleukin 1 | DNA methylation | Respiratory tract diseases | Children | Deoxyribonucleic acid--DNA | Hypersensitivity | Interleukin 13 | Eosinophilia | Asthma | Lungs | Nitric oxide | Biomarkers | Methylation | Acceleration | Index Medicus
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12. Full Text Gender differences in COPD: are women more susceptible to smoking effects than men?
by Sørheim, Inga-Cecilie and Johannessen, Ane and Gulsvik, Amund and Bakke, Per S and Silverman, Edwin K and DeMeo, Dawn L
Thorax, ISSN 0040-6376, 06/2010, Volume 65, Issue 6, pp. 480 - 485
BackgroundThe number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a... 
OBSTRUCTIVE PULMONARY-DISEASE | METAANALYSIS | COMMUNITY | RESPIRATORY SYSTEM | EMPHYSEMA | RISK | SEX-DIFFERENCES | PREVALENCE | FEMALE SMOKERS | EXPOSURE | HABITS | Smoking - adverse effects | Disease Susceptibility | Age Factors | Humans | Middle Aged | Risk Factors | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - epidemiology | Forced Expiratory Volume | Asthma - complications | Smoking - epidemiology | Norway - epidemiology | Smoking - physiopathology | Sex Factors | Adult | Female | Aged | Asthma - epidemiology | Lung diseases, Obstructive | Demographic aspects | Sex factors in disease | Research | Health aspects | Risk factors | Smoking
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