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1. Full Text The recursive trek of epigenetics from the bench to the bedside predictive methylation marks by the Dozen
by DeMeo, Dawn L
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2018, Volume 198, Issue 2, pp. 145 - 146
In a study presented in this issue of the Journal, Leng and colleagues (pp. 187-196) used a nested methylation-specific PCR approach to investigate whether a... 
RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE | DNA Methylation | Smokers | Epigenesis, Genetic | Humans | Sputum | Studies | Smoking cessation | Lung cancer | Mortality | Genes | DNA methylation | Biomarkers | Epigenetics | Genomes | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA
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2. Full Text Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome
by Wan, Emily S and Qiu, Weiliang and Baccarelli, Andrea and Carey, Vincent J and Bacherman, Helene and Rennard, Stephen I and Agusti, Alvar and Anderson, Wayne and Lomas, David A and Demeo, Dawn L
Human Molecular Genetics, ISSN 0964-6906, 07/2012, Volume 21, Issue 13, pp. 3073 - 3082
The impact of cigarette smoking can persist for extended periods following smoking cessation and may involve epigenetic reprogramming. Changes in DNA... 
BREAST-CANCER | GENE-EXPRESSION SIGNATURE | WHOLE-BLOOD | OBSTRUCTIVE PULMONARY-DISEASE | LINEAR MIXED MODELS | PROMOTER METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | ACUTE LUNG INJURY | RISK | LIGHT-CHAIN-KINASE | SELF-REPORTED SMOKING | Smoking - adverse effects | Cross-Sectional Studies | Humans | Middle Aged | Male | Smoking - genetics | Receptors, Peptide - genetics | DNA Methylation | Receptors, Thrombin - genetics | Female | Receptors, G-Protein-Coupled - genetics | Genome, Human | Cohort Studies | Smoking Cessation | Association Studies
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3. Full Text Correction: Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism
by Lopes-Ramos, Camila M and Kuijjer, Marieke L and Ogino, Shuji and Fuchs, Charles S and DeMeo, Dawn L and Glass, Kimberly and Quackenbush, John
Cancer research, ISSN 0008-5472, 04/2019, Volume 79, Issue 8, pp. 2084 - 2084
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4. Full Text Correction: Gene regulatory network analysis identifies sex-linked differences in colon cancer drug metabolism (Cancer Res (2019) 78 (5538–5547) DOI: 10.1158/0008-5472.CAN-18-0454)
by Lopes-Ramos, Camila M and Kuijjer, Marieke L and Ogino, Shuji and Fuchs, Charles S and DeMeo, Dawn L and Glass, Kimberly and Quackenbush, John
Cancer Research, ISSN 0008-5472, 04/2019, Volume 79, Issue 8, p. 2084
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5. Full Text DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
by Joubert, Bonnie R and Felix, Janine F and Yousefi, Paul and Bakulski, Kelly M and Just, Allan C and Breton, Carrie and Reese, Sarah E and Markunas, Christina A and Richmond, Rebecca C and Xu, Cheng-Jian and Xu, Zongli and Küpers, Leanne K and Oh, Sam S and Hoyo, Cathrine and Gruzieva, Olena and Söderhäll, Cilla and Salas, Lucas A and Baïz, Nour and Zhang, Hongmei and Lepeule, Johanna and Ruiz, Carlos and Ligthart, Symen and Wang, Tianyuan and Taylor, Jack A and Duijts, Liesbeth and Sharp, Gemma C and Jankipersadsing, Soesma A and Nilsen, Roy M and Vaez, Ahmad and Fallin, M. Daniele and Hu, Donglei and Litonjua, Augusto A and Fuemmeler, Bernard F and Huen, Karen and Kere, Juha and Kull, Inger and Munthe-Kaas, Monica Cheng and Gehring, Ulrike and Bustamante, Mariona and Saurel-Coubizolles, Marie José and Quraishi, Bilal M and Ren, Jie and Tost, Jörg and Gonzalez, Juan R and Peters, Marjolein J and Håberg, Siri E and van Meurs, Joyce B and Gaunt, Tom R and Kerkhof, Marjan and Corpeleijn, Eva and Feinberg, Andrew P and Eng, Celeste and Baccarelli, Andrea A and Benjamin Neelon, Sara E and Bradman, Asa and Merid, Simon Kebede and Bergström, Anna and Herceg, Zdenko and Hernandez-Vargas, Hector and Brunekreef, Bert and Pinart, Mariona and Heude, Barbara and Ewart, Susan and Yao, Jin and Lemonnier, Nathanaël and Franco, Oscar H and Wu, Michael C and Hofman, Albert and McArdle, Wendy and Van der Vlies, Pieter and Falahi, Fahimeh and Gillman, Matthew W and Barcellos, Lisa F and Kumar, Ashish and Wickman, Magnus and Guerra, Stefano and Charles, Marie-Aline and Holloway, John and Auffray, Charles and Tiemeier, Henning W and Smith, George Davey and Postma, Dirkje and Hivert, Marie-France and Eskenazi, Brenda and Vrijheid, Martine and Arshad, Hasan and Antó, Josep M and Dehghan, Abbas and Karmaus, Wilfried and Annesi-Maesano, Isabella and Sunyer, Jordi and Ghantous, Akram and Pershagen, Göran and Holland, Nina and Murphy, Susan K and DeMeo, Dawn L and Burchard, Esteban G and Ladd-Acosta, Christine and Snieder, Harold and Nystad, Wenche and ...
The American Journal of Human Genetics, ISSN 0002-9297, 04/2016, Volume 98, Issue 4, pp. 680 - 696
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy... 
BREAST-CANCER | IN-UTERO | CIGARETTE-SMOKING | LYMPH-NODE METASTASIS | PRENATAL EXPOSURE | TOBACCO-SMOKING | GENETICS & HEREDITY | LUNG-FUNCTION DECLINE | NEUROPILIN-2 EXPRESSION | AUTISM SPECTRUM DISORDERS | POSTSYNAPTIC DENSITY | Smoking - adverse effects | European Continental Ancestry Group - genetics | Genetic Association Studies | Epigenesis, Genetic | Humans | Child, Preschool | Infant | Chromosome Mapping | Cleft Palate - genetics | Asthma - genetics | Pregnancy | Cleft Lip - genetics | DNA Methylation | Cleft Palate - etiology | Female | Asthma - etiology | Child | Infant, Newborn | Cleft Lip - etiology | Genome-wide association studies | Genetic aspects | Nucleotide sequencing | Methylation | Health aspects | Methods | DNA sequencing | Smoking | Newborn babies | DNA methylation | Genomes | Mothers | Meta-analysis
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6. Full Text Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function
by Qiu, Weiliang and Baccarelli, Andrea and Carey, Vincent J and Boutaoui, Nadia and Bacherman, Helene and Klanderman, Barbara and Rennard, Stephen and Agusti, Alvar and Anderson, Wayne and Lomas, David A and DeMeo, Dawn L
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2012, Volume 185, Issue 4, pp. 373 - 381
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with local (lung) and systemic (blood) inflammation and manifestations. DNA methylation... 
DNA methylation | Epigenetics | Chronic obstructive pulmonary disease | Smoking | HYPERMETHYLATION | ADHESION MOLECULES | CANCER | epigenetics | ABERRANT PROMOTER METHYLATION | MULTIPLE GENES | K-RAS | EPITHELIUM | RESPIRATORY SYSTEM | smoking | CHRONIC SMOKERS | EXPRESSION | chronic obstructive pulmonary disease | CRITICAL CARE MEDICINE | Smoking - adverse effects | Genetic Predisposition to Disease | alpha 1-Antitrypsin - genetics | Oligonucleotide Array Sequence Analysis | Epigenesis, Genetic | Humans | Middle Aged | Linear Models | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Genetic Markers | Forced Expiratory Volume | Vital Capacity | DNA Methylation | Phenotype | CpG Islands - genetics | Female | Cohort Studies | Pulmonary Disease, Chronic Obstructive - genetics
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7. Full Text Gender differences in COPD: are women more susceptible to smoking effects than men?
by Sørheim, Inga-Cecilie and Johannessen, Ane and Gulsvik, Amund and Bakke, Per S and Silverman, Edwin K and DeMeo, Dawn L
Thorax, ISSN 0040-6376, 06/2010, Volume 65, Issue 6, pp. 480 - 485
BackgroundThe number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a... 
OBSTRUCTIVE PULMONARY-DISEASE | METAANALYSIS | COMMUNITY | RESPIRATORY SYSTEM | EMPHYSEMA | RISK | SEX-DIFFERENCES | PREVALENCE | FEMALE SMOKERS | EXPOSURE | HABITS | Smoking - adverse effects | Disease Susceptibility | Age Factors | Humans | Middle Aged | Risk Factors | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - epidemiology | Forced Expiratory Volume | Asthma - complications | Smoking - epidemiology | Norway - epidemiology | Smoking - physiopathology | Sex Factors | Adult | Female | Aged | Asthma - epidemiology | Lung diseases, Obstructive | Demographic aspects | Sex factors in disease | Research | Health aspects | Risk factors | Smoking
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8. Full Text Translating genomics into risk prediction
by Wan, Emily S and DeMeo, Dawn L
Thorax, ISSN 0040-6376, 07/2017, Volume 72, Issue 7, pp. 598 - 599
By modifying the technology employed in genome-wide genetic studies, quantitative assessments of DNA methylation at tens to hundreds of thousands of sites... 
Tobacco and the lung | BIOMARKERS | LUNG-CANCER MORTALITY | CIGARETTE-SMOKING | RESPIRATORY SYSTEM | GENES | DIFFERENTIAL DNA METHYLATION | Risk | Genomics | Humans | Prevention | Lung diseases | Research | Health risk assessment | Biological markers | Cardiovascular diseases | Methods | Risk factors | DNA methylation | Tobacco smoke | Mortality
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9. Full Text Optimism and cause-specific mortality: A prospective cohort study
by Kim, Eric S and Hagan, Kaitlin A and Grodstein, Francine and DeMeo, Dawn L and De Vivo, Immaculata and Kubzansky, Laura D
American Journal of Epidemiology, ISSN 0002-9262, 2017, Volume 185, Issue 1, pp. 21 - 29
Growing evidence has linked positive psychological attributes like optimism to a lower risk of poor health outcomes, especially cardiovascular disease. It has... 
Health psychology | Psychological well-being | Optimism | Resilience | DEPRESSION | optimism | OLDER-ADULTS | psychological well-being | health psychology | ACUTE CORONARY SYNDROME | PESSIMISM | CARDIOVASCULAR HEALTH | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DISEASE | MEN | DISPOSITIONAL OPTIMISM | PHYSICAL-ACTIVITY | resilience | ASSOCIATION | United States - epidemiology | Women's Health | Humans | Middle Aged | Proportional Hazards Models | Death Certificates | Health Behavior | Cause of Death | Socioeconomic Factors | Optimism - psychology | Depression - psychology | Female | Aged | Resilience, Psychological | Longitudinal Studies | Original Contributions
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10. Full Text Clinical and Radiologic Disease in Smokers With Normal Spirometry
by Regan, Elizabeth A and Lynch, David A and Curran-Everett, Douglas and Curtis, Jeffrey L and Austin, John H. M and Grenier, Philippe A and Kauczor, Hans-Ulrich and Bailey, William C and DeMeo, Dawn L and Casaburi, Richard H and Friedman, Paul and Van Beek, Edwin J. R and Hokanson, John E and Bowler, Russell P and Beaty, Terri H and Washko, George R and Han, MeiLan K and Kim, Victor and Kim, Song Soo and Yagihashi, Kunihiro and Washington, Lacey and McEvoy, Charlene E and Tanner, Clint and Mannino, David M and Make, Barry J and Silverman, Edwin K and Crapo, James D and Genetic Epidemiology COPD Copdgene and Genetic Epidemiology of COPD (COPDGene) Investigators
JAMA Internal Medicine, ISSN 2168-6106, 09/2015, Volume 175, Issue 9, pp. 1539 - 1549
IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without... 
MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKING | NORTHERN SWEDEN | EMPHYSEMA | LUNG-FUNCTION | NATURAL-HISTORY | AIRWAYS | COMPUTED-TOMOGRAPHY | AIR-FLOW OBSTRUCTION | COPD | Smoking - adverse effects | Spirometry | United States - epidemiology | Cross-Sectional Studies | Nutrition Surveys | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - epidemiology | Case-Control Studies | Exercise Tolerance | Quality of Life | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Aged | Radiography, Thoracic | CT imaging | Lung diseases, Obstructive | Care and treatment | Usage | Smokers | Health aspects
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11. Full Text Variants in FAM13A are associated with chronic obstructive pulmonary disease
by Cho, Michael H and Kong, Xiangyang and Regan, Elizabeth A and Lomas, David A and Klanderman, Barbara J and Sparrow, David and Hokanson, John E and Ziniti, John P and Hunninghake, Gary M and Make, Barry J and Crapo, James D and Lange, Christoph and Murphy, James R and Anderson, Wayne H and Beaty, Terri H and Tal-Singer, Ruth and Sylvia, Jody S and Hersh, Craig P and Boutaoui, Nadia and Bakke, Per and Gulsvik, Amund and Pillai, Sreekumar G and Litonjua, Augusto A and Silverman, Edwin K and Won, Sungho and DeMeo, Dawn L
Nature Genetics, ISSN 1061-4036, 03/2010, Volume 42, Issue 3, pp. 200 - 202
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380... 
GENE-EXPRESSION | GENETICS & HEREDITY | Smoking - adverse effects | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Smoking - genetics | Pulmonary Disease, Chronic Obstructive - etiology | Case-Control Studies | Chromosomes, Human, Pair 4 | Linkage Disequilibrium | Multicenter Studies as Topic | Family | Polymorphism, Single Nucleotide | Receptors, G-Protein-Coupled - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Receptors, G-Protein-Coupled - physiology | Lung diseases, Obstructive | Genetic aspects | Genetic variation | Health aspects | Risk factors | Studies | Signal transduction | Mortality | Genetics | Population | Regression analysis | Gene expression | Methods | Smoking
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12. Full Text Epigenetic Signatures of Cigarette Smoking
by Joehanes, Roby and Just, A.C and Marioni, Riccardo and Pilling, Luke and Reynolds, Lindsay and Mandaviya, P.R and Guan, Weihua and Xu, T and Elks, Cathy and Aslibekyan, S and Moreno-Macías, Hortensia and Smith, Jennifer A and Brody, Jennifer and Dhingra, R and Yousefi, Paul and Pankow, James and Kunze, S and Shah, S.H and McRae, Allan F and Lohman, Kurt and Sha, J and Absher, Devin and Ferrucci, Luigi and Zhao, W and Demerath, Ellen and Bressler, Jan and Grove, Megan and Huan, Tianxiao and Liu, Chunyu and Mendelson, M.M and Yao, Chen and Kiel, Douglas P and Peters, Annette and Wang-Sattler, Rui and Visscher, Peter and Wray, Naomi and Starr, John and Ding, J and Roiguez, C.J and Wareham, Nick and Irvin, M.R and Zhi, D and Barrdahl, Myrto and Vineis, Paolo and Ambatipudi, S and Uitterlinden, Ané and Hofman, Albert and Schwartz, J and Colicino, E and Hou, L and Vokonas, P.S and Hernandez, Dena and Singleton, Anew and Bandinelli, Stefania and Turner, Stephen and Ware, Erin B and Smith, A.K and Klengel, Torsten and Binder, Elisabeth B and Psaty, Bruce and Taylor, Kent and Gharib, Sina and Swenson, B.R and Liang, L and Demeo, Dawn L and O'Connor, George and Herceg, Zdenko and Ressler, K.J and Conneely, Karen N and Sotoodehnia, Nona and Kardia, S.L.R and Melzer, David and Baccarelli, Anea A and Meurs, Joyce and Romieu, Isabelle and Arnett, Donna and Ong, K.K and Liu, Yongmei and Waldenberger, Melanie and Deary, Ian J and Fornage, Myriam and Levy, Daniel and London, Stephanie J
Circulation: Cardiovascular Genetics, ISSN 1942-325X, 10/2016, Volume 9, Issue 5, pp. 436 - 447
textabstractBackground-DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to... 
meta-analysis | biomarkers | methylation | genome-wide association study | smoking | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CANCER | DISCOVERY | DIFFERENTIAL DNA METHYLATION | F2RL3 METHYLATION | HUMAN GENOME | GENETICS & HEREDITY | NUTRITION | EXPRESSION | EPIGENOME-WIDE ASSOCIATION | Smoking - adverse effects | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Epigenesis, Genetic | Humans | Middle Aged | Transcriptome | Gene Expression Profiling - methods | Genotype | Male | Smoking - genetics | Genetic Markers | Smoking Prevention | Case-Control Studies | Smoking - ethnology | DNA Methylation | Phenotype | Time Factors | CpG Islands | Female | Aged | Leukocytes - chemistry | Smoking Cessation | Genome Wide Association Study | biomarker | epigenetics
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13. Full Text MMP12, Lung Function, and COPD in High-Risk Populations
by Hunninghake, Gary M and Cho, Michael H and Tesfaigzi, Yohannes and Soto-Quiros, Manuel E and Avila, Lydiana and Lasky-Su, Jessica and Stidley, Chris and Melén, Erik and Söderhäll, Cilla and Hallberg, Jenny and Kull, Inger and Kere, Juha and Svartengren, Magnus and Pershagen, Göran and Wickman, Magnus and Lange, Christoph and Demeo, Dawn L and Hersh, Craig P and Klanderman, Barbara J and Raby, Benjamin A and Sparrow, David and Shapiro, Steven D and Silverman, Edwin K and Litonjua, Augusto A and Weiss, Scott T and Celedón, Juan C
The New England Journal of Medicine, ISSN 0028-4793, 12/2009, Volume 361, Issue 27, pp. 2599 - 2608
A variant of MMP12, encoding a matrix metallopeptidase, is associated with increased lung function in children with asthma and in adult smokers. It is also... 
MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | POLYMORPHISMS | GENE | SMOKERS | EMPHYSEMA | GROWTH | ASSOCIATION | CHILDHOOD ASTHMA | AIR-FLOW OBSTRUCTION | DECLINE | Forced Expiratory Volume - genetics | Promoter Regions, Genetic | Genetic Predisposition to Disease | Asthma - physiopathology | Humans | Middle Aged | Male | Matrix Metalloproteinase 12 - genetics | Smoking - genetics | Pulmonary Disease, Chronic Obstructive - physiopathology | Genetic Markers | Asthma - genetics | Smoking - physiopathology | Alleles | Adult | Female | Aged | Polymorphism, Single Nucleotide | Child | Cohort Studies | Pulmonary Disease, Chronic Obstructive - genetics | Medical research | Disease management | Emphysema | Risk factors
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