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Nature Reviews Immunology, ISSN 1474-1733, 2019, Volume 19, Issue 6, pp. 369 - 382
Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This... 
Molecular targeted therapy | Care and treatment | Immune response | Immunotherapy | Macrophages | Health aspects | Methods | Tumors | Medical research | Regulators | Clinical trials | Homeostasis | Lymphocytes T | Immunity | Metastases | Angiogenesis | Lymphocytes | Fibrosis | Hypoxia | Combinatorial analysis | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. SY06-03 - SY06-03
Journal Article
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 621 - 623
T cell checkpoint blockades can produce durable clinical responses, but only some patients and cancer types respond. In this issue of , show B7S1-B7S1R... 
IMMUNOLOGY | CANCER | B7-H4 | FAMILY | Signal Transduction | Humans | Neoplasms | Skin Diseases | Myeloid Cells | T cells | Medical colleges | Antigens | Transcription factors | CD8 antigen | Cytotoxicity | T cell receptors | Lymphocytes T | Kinases | Patients | Immunity | Studies | Genotype & phenotype | Immune checkpoint | Lymphocytes | Epigenetics | Tumor necrosis factor-TNF | Cancer | Tumors
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 08/2019, Volume 9, Issue 8, pp. 1001 - 1002
Cancer-associated fibroblasts (CAF) have been implicated in diverse and sometimes divergent tumor modulatory processes that can be explained only by the... 
ONCOLOGY
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 07/2019, Volume 11, Issue 499, p. eaau9240
Although checkpoint immunotherapies have revolutionized the treatment of cancer, not all tumor types have seen substantial benefit. Pancreatic ductal... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION | RESPONSES | DENDRITIC CELLS | INTEGRIN | INFLAMMATION | TUMOR-INFILTRATING MACROPHAGES | MAC-1 | IMPROVES | BLOCKADE | EXPRESSION | CELL BIOLOGY
Journal Article
Oncogenesis, ISSN 2157-9024, 03/2018, Volume 7, Issue 3, pp. 32 - 13
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 5, pp. 651 - 662
Journal Article
Cancer Research, ISSN 0008-5472, 07/2014, Volume 74, Issue 18, pp. 5057 - 5069
Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor... 
ACTIVATION | INHIBITION | MICROENVIRONMENT | ONCOLOGY | ADENOCARCINOMA | INFLAMMATION | KINASE | CSF | POLARIZATION | IPILIMUMAB | PROGRESSION | Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Immunotherapy - methods | Receptor, Macrophage Colony-Stimulating Factor - immunology | Adenocarcinoma - pathology | Macrophage Colony-Stimulating Factor - biosynthesis | Mannose-Binding Lectins - biosynthesis | Tissue Array Analysis | Humans | Lectins, C-Type - immunology | Tumor Microenvironment | Deoxycytidine - pharmacology | Lectins, C-Type - biosynthesis | Female | Receptors, Cell Surface - biosynthesis | Carcinoma, Pancreatic Ductal - immunology | Macrophages - immunology | Signal Transduction | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Adenocarcinoma - immunology | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - therapy | Random Allocation | Carcinoma, Pancreatic Ductal - pathology | Receptors, Cell Surface - immunology | Macrophage Colony-Stimulating Factor - immunology | Animals | Mannose-Binding Lectins - immunology | Pancreatic Neoplasms - immunology | T-Lymphocytes - immunology | Mice | Deoxycytidine - analogs & derivatives | Cohort Studies | Pancreatic Neoplasms - therapy | macrophage | chemoresistance | pancreatic cancer | cytokines | innate immunity | immune checkpoint
Journal Article
Cancer Research, ISSN 0008-5472, 01/2015, Volume 75, Issue 1 Supplement, pp. A28 - A28
Journal Article
Cancer and Metastasis Reviews, ISSN 0167-7659, 06/2010, Volume 29, Issue 2, pp. 309 - 316
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. e15217 - e15217
Journal Article
Cancer Research, ISSN 0008-5472, 02/2013, Volume 73, Issue 3, pp. 1128 - 1141
Journal Article