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1. Full Text Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome
by Cogram, P and Deacon, RMJ and Warner-Schmidt, JL and von Schimmelmann, MJ and Abrahams, BS and During, MJ
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, ISSN 1662-5153, 06/2019, Volume 13, p. 141
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity,... 
TARGET | hyperactivity | FMRP | OV101 | aggression | PREVALENCE | NEUROSCIENCES | stereotypy | anxiety | GABA(A) RECEPTOR | GENE | GABA | BEHAVIORAL SCIENCES | MICE | THIP | TONIC INHIBITION | EXPRESSION | BRAIN | SUBUNIT | Autism | Models | Fragile X syndrome | Analysis | Potentiation | Self-injury | Amygdala | γ-Aminobutyric acid A receptors | Intellectual disabilities | Aggression | Hyperactivity | Mental retardation | Proteins | Consortia | γ-Aminobutyric acid | Hypotheses | Fragile X mental retardation protein | Sleep | Anxieties | Rodents | Anxiety | Behavior | γ-Aminobutyric acid receptors | FMR1 protein
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2. Full Text Editorial: Human and animal models for translational research on neurodegeneration: Challenges and opportunities from South America
by Ibáñez, Agustín and Sedeño, Lucas and García, Adolfo M and Deacon, Robert M.J and Cogram, Patricia
Frontiers in Aging Neuroscience, ISSN 1663-4365, 04/2018, Volume 10, p. 95
Even considering these data, SACs possess the highest global prevalence of dementia after North Africa/Middle East in people above the age of 60 (Parra et al.,... 
Human experimentation | South America | Neurosciences | Animals | Neurodegenerative diseases | Clinical protocols | Research | Public health | neurosciences | SIGNATURES | RECOGNITION | VARIANT FRONTOTEMPORAL DEMENTIA | research | GERIATRICS & GERONTOLOGY | neurodegenerative diseases | human experimentation | INTEGRATION | MEMORY BINDING DEFICITS | FAMILIAL ALZHEIMERS-DISEASE | BEHAVIORAL VARIANT | animals | LANGUAGE DEFICITS | clinical protocols | HUNTINGTONS-DISEASE | public health | PARKINSONS-DISEASE | Neuroimaging | Metabolomics | Phenotypes | Animal models | Translation | Memory | Case reports | Epidemiology | Brain research | Neurodegeneration | Neural networks | Collaboration | Proteomics | Epigenetics | Dementia disorders | Biomarkers | Frontotemporal dementia | Alzheimers disease | Niches | Dementia | Animal cognition
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3. Full Text Assessing nest building in mice
by Deacon, Robert M.J
Nature Protocols, ISSN 1754-2189, 08/2006, Volume 1, Issue 3, pp. 1117 - 1119
For small rodents, nests are important in heat conservation as well as reproduction and shelter. Nesting is easily measured in the home cages of mice,... 
MATERNAL-BEHAVIOR | MUS-MUSCULUS | LESIONS | ENHANCEMENT | MOUSE | BIOCHEMICAL RESEARCH METHODS | Animals, Laboratory - physiology | Animals | Behavioral Symptoms - diagnosis | Housing, Animal | Nesting Behavior - physiology | Mice | Psychomotor Performance - physiology
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4. Full Text Digging and marble burying in mice: Simple methods for in vivo identification of biological impacts
by Deacon, Robert M.J
Nature Protocols, ISSN 1754-2189, 06/2006, Volume 1, Issue 1, pp. 122 - 124
Mice exhibit various species-typical behaviors such as digging and burrowing. They dig in the ground to find food, to hoard food, to create a refuge from... 
ANXIETY | BEHAVIOR | BIOCHEMICAL RESEARCH METHODS | RATS | MODEL | ANTAGONISTS | UPTAKE INHIBITORS | Behavior, Animal | Mice | Animals | Behavioral Research - methods | Housing, Animal
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5. Full Text Measuring motor coordination in mice
by Deacon, Robert M J
Journal of visualized experiments : JoVE, ISSN 1940-087X, 2013, Issue 75, p. e2609
Mice are increasingly being used in behavioral neuroscience, largely replacing rats as the behaviorist's animal of choice. Before aspects of behavior such as... 
parallel bars | Psychology | MULTIDISCIPLINARY SCIENCES | Neurobiology | Anatomy | horizontal bar | static rods | coordination | Neuroscience | Physiology | Mice | Behavior | Issue 75 | motor behaviour | animal model | rotarod | Motor Activity - physiology | Biomechanical Phenomena | Rotarod Performance Test | Animals | Sex Factors | Female | Male | Gait - physiology | Mice - physiology
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6. Full Text Novel ketone diet enhances physical and cognitive performance
by Murray, Andrew J and Knight, Nicholas S and Cole, Mark A and Cochlin, Lowri E and Carter, Emma and Tchabanenko, Kirill and Pichulik, Tica and Gulston, Melanie K and Atherton, Helen J and Schroeder, Marie A and Deacon, Robert M. J and Kashiwaya, Yoshihiro and King, M. Todd and Pawlosky, Robert and Rawlins, J. Nicholas P and Tyler, Damian J and Griffin, Julian L and Robertson, Jeremy and Veech, Richard L and Clarke, Kieran
FASEB Journal, ISSN 0892-6638, 12/2016, Volume 30, Issue 12, pp. 4021 - 4032
Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP... 
Energetics | Heart | Muscle | Exercise | Metabolism | ESTER | BETA-HYDROXYBUTYRATE | MITOCHONDRIAL BIOGENESIS | EXERCISE PERFORMANCE | UNCOUPLING PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | exercise | KETOGENIC DIET | heart | CELL BIOLOGY | FAILING HEART | muscle | BIOLOGY | metabolism | ENERGY-METABOLISM | energetics | ALZHEIMERS | KETOSIS | Dietary Fats - metabolism | Rats, Wistar | Cholesterol - blood | Ketones - administration & dosage | Male | Dietary Carbohydrates - metabolism | Feeding Behavior - physiology | Energy Intake - physiology | Insulin - metabolism | Animals | Diet | Triglycerides - blood | Cognition - physiology | Energy Metabolism - physiology | Research
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7. Full Text Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium
by Murray, Carol and Sanderson, David J and Barkus, Chris and Deacon, Robert M.J and Rawlins, J. Nicholas P and Bannerman, David M and Cunningham, Colm
Neurobiology of Aging, ISSN 0197-4580, 2012, Volume 33, Issue 3, pp. 603 - 616.e3
Abstract Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is... 
Neurology | Internal Medicine | Delirium | Infection | Animal model | Synaptic | Predisposition | Priming | Inflammation | Microglia | Dementia | ALZHEIMER-DISEASE | PERIPHERAL INFECTION | RISK-FACTORS | MURINE PRION DISEASE | INNATE IMMUNE-SYSTEM | SICKNESS BEHAVIOR | AGED MICE | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | COGNITIVE TEST | CHRONIC NEURODEGENERATION | ELDERLY-PATIENTS | Delirium - pathology | Inflammation - pathology | Inflammation Mediators - administration & dosage | Memory Disorders - physiopathology | Acute Disease | Dementia - pathology | Lipopolysaccharides - administration & dosage | Mice, Inbred C57BL | Dementia - physiopathology | Memory, Short-Term - physiology | Inflammation - complications | Animals | Female | Mice | Memory Disorders - pathology | Delirium - physiopathology | Disease Models, Animal | Mitogens | Analysis | Short-term memory | Regular Paper
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8. Full Text Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life
by Hassaan, PS and Dief, AE and Zeitoun, TM and Baraka, AM and Deacon, RMJ and Elshorbagy, A
PLOS ONE, ISSN 1932-6203, 08/2019, Volume 14, Issue 8, pp. e0220720 - e0220720
Although monosodium glutamate (MSG)-induced neurotoxicity has been recognized for decades, the potential similarities of the MSG model to Alzheimer's disease... 
HIPPOCAMPUS | NEONATAL EXPOSURE | PHOSPHORYLATION | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SITES | PATHOLOGY | MODEL | NEUROTOXICITY | SPECIES-TYPICAL BEHAVIORS | LESIONS | Monosodium glutamate | Development and progression | Models | Health aspects | Alzheimer's disease | Tau proteins | Risk factors | Immunohistochemistry | Neuropathology | Memory | Cotton | Proteins | Sodium glutamate | Neurotoxicity | Neurodegeneration | Rodents | Physiology | Behavior | Spongiform encephalopathy | Medical research | Activities of daily living | Neurons | Cortex | Neuropil | Burrowing behavior | Quality of life | Medicine | Pathology | Tau protein | Mice | Alzheimers disease | Short term memory | Hippocampus | Dementia | Animal cognition | Index Medicus
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9. Full Text Measuring the strength of mice
by Deacon, Robert M J
Journal of visualized experiments : JoVE, ISSN 1940-087X, 2013, Issue 76
Kondziela(7) devised the inverted screen test and published it in 1964. It is a test of muscle strength using all four limbs. Most normal mice easily score... 
motor | strength | weight lifting | Psychology | MULTIDISCIPLINARY SCIENCES | Neurobiology | Anatomy | Medicine | inverted screen | Neuroscience | Issue 76 | Physiology | Mice | Behavior | animal model | Animals | Mice, Inbred C57BL | Weight Lifting | Female | Male | Muscle, Skeletal - physiology
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10. Full Text Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech Deficits
by Groszer, Matthias and Keays, David A and Deacon, Robert M.J and de Bono, Joseph P and Prasad-Mulcare, Shweta and Gaub, Simone and Baum, Muriel G and French, Catherine A and Nicod, Jérôme and Coventry, Julie A and Enard, Wolfgang and Fray, Martin and Brown, Steve D.M and Nolan, Patrick M and Pääbo, Svante and Channon, Keith M and Costa, Rui M and Eilers, Jens and Ehret, Günter and Rawlins, J. Nicholas P and Fisher, Simon E
Current Biology, ISSN 0960-9822, 03/2008, Volume 18, Issue 5, pp. 354 - 362
The most well-described example of an inherited speech and language disorder is that observed in the multigenerational KE family, caused by a heterozygous... 
SYSNEURO | ABNORMALITIES | INHERITED SPEECH | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LONG-TERM DEPRESSION | FOXP2 GENE | LANGUAGE DISORDER | ULTRASOUNDS | IDENTIFICATION | STRIATUM | BRAIN | Motor Skills - physiology | Humans | Speech Disorders - genetics | Repressor Proteins - genetics | Vocalization, Animal - physiology | Forkhead Transcription Factors - genetics | Mice, Knockout | Learning - physiology | Point Mutation | Neuronal Plasticity - genetics | Animals | Alleles | Heterozygote | Mice | Gene mutations | Physiological aspects | Genetic aspects | Report
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11. Full Text Burrowing in rodents: A sensitive method for detecting behavioral dysfunction
by Deacon, Robert M.J
Nature Protocols, ISSN 1754-2189, 06/2006, Volume 1, Issue 1, pp. 118 - 121
Virtually all rodents display burrowing behavior, yet measurement of this behavior has not yet been standardized or formalized. Previously, parameters such as... 
MICE | BIOCHEMICAL RESEARCH METHODS | Behavior, Animal | Gerbillinae - physiology | Cricetinae | Animals | Rodentia - psychology | Behavioral Research - methods | Housing, Animal | Behavioral Research - instrumentation | Rats | Mice | Gerbillinae - psychology | Rodentia - physiology
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12. Full Text Anxiolytic Effects of Cytotoxic Hippocampal Lesions in Rats
by Deacon, Robert M. J and Bannerman, David M and Rawlins, J. Nicholas P
Behavioral Neuroscience, ISSN 0735-7044, 6/2002, Volume 116, Issue 3, pp. 494 - 497
Rats with cytotoxic lesions of the hippocampus were given 3 anxiety tests: social interaction with a novel rat, the elevated zero-maze (a modification of the... 
Exploratory Behavior - physiology | Animals | Ibotenic Acid - toxicity | Maze Learning - physiology | Anxiety - physiopathology | Rats | Male | Anxiety - chemically induced | Anxiety - prevention & control | Hippocampus - drug effects | Hippocampus - physiology | Interpersonal Relations | Neurology | Anxiety | Research
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13. Full Text T-maze alternation in the rodent
by Deacon, Robert M.J and Rawlins, J. Nicholas P
Nature Protocols, ISSN 1754-2189, 06/2006, Volume 1, Issue 1, pp. 7 - 12
This protocol details a method for using a T-maze to assess the cognitive ability of rodents. The T-maze is an elevated or enclosed apparatus in the form of a... 
ANXIETY | HIPPOCAMPAL-LESIONS | ALZHEIMERS-DISEASE | MOUSE | BIOCHEMICAL RESEARCH METHODS | RATS | MICE | MODEL | BEHAVIORS | Animals | Maze Learning | Rodentia - psychology | Choice Behavior | Cognition | Reward | Intelligence Tests
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14. Full Text Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease
by Cunningham, Colm and Campion, Suzanne and Lunnon, Katie and Murray, Carol L and Woods, Jack F.C and Deacon, Robert M.J and Rawlins, J. Nicholas P and Perry, V. Hugh
Biological Psychiatry, ISSN 0006-3223, 2009, Volume 65, Issue 4, pp. 304 - 312
Background Chronic neurodegeneration results in microglial activation, but the contribution of inflammation to the progress of neurodegeneration remains... 
Psychiatry | systemic | inflammation | neurodegeneration | microglial priming | cytokines | Alzheimer's disease | delirium | PERIPHERAL INFECTION | C57BL/6J MICE | MURINE PRION DISEASE | PSYCHIATRY | ALZHEIMERS-DISEASE | SICKNESS BEHAVIOR | NEUROSCIENCES | ME7 MODEL | MESSENGER-RNA | MOUSE MODEL | ANTIINFLAMMATORY DRUGS | INNATE IMMUNITY | Immunohistochemistry | Inflammation - psychology | Body Temperature - drug effects | Neurodegenerative Diseases - etiology | Neurodegenerative Diseases - psychology | Mice, Inbred C57BL | Infusions, Parenteral | Motor Activity - drug effects | Behavior, Animal - physiology | Maze Learning - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Psychomotor Performance - physiology | Inflammation - complications | Animals | Lipopolysaccharides - pharmacology | Cognition - physiology | Female | Mice | Longitudinal Studies | Neurosciences | Inflammation | Mitogens | Archival Report
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