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SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 1 - 11
Given the number of global malaria cases and deaths, the need for a vaccine against Plasmodium falciparum (Pf) remains pressing. Administration of live,... 
PARASITES | IMMUNITY | IMMUNIZATION | TRANSMISSION | LIVER STAGE | PROTECTION | MULTIDISCIPLINARY SCIENCES | MOVEMENT | MALARIA SPOROZOITES | DERMIS | Explants | Motility | Malaria | Image processing | Infectivity | Sporozoites | Skin | Vaccines | Parasites
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 522, Issue 7556, pp. 315 - 320
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 248 - 253
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase,... 
YEAST | TRANSMISSION | POTENT | VIVAX | PHOSPHATIDYLINOSITOL 4-PHOSPHATE | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | KINASE | ZINC-FINGER NUCLEASES | SACCHAROMYCES-CEREVISIAE | Plasmodium - enzymology | Phosphatidylinositol Phosphates - metabolism | Humans | Male | rab GTP-Binding Proteins - genetics | Macaca mulatta | Plasmodium - drug effects | Hepatocytes - parasitology | 1-Phosphatidylinositol 4-Kinase - metabolism | Quinoxalines - pharmacology | Schizonts - cytology | Adenosine Triphosphate - metabolism | Plasmodium - growth & development | Female | Binding Sites | Fatty Acids - metabolism | Cytokinesis - drug effects | Imidazoles - metabolism | Life Cycle Stages - drug effects | Pyrazoles - pharmacology | 1-Phosphatidylinositol 4-Kinase - genetics | rab GTP-Binding Proteins - metabolism | 1-Phosphatidylinositol 4-Kinase - chemistry | Reproducibility of Results | Models, Molecular | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Drug Resistance - drug effects | Imidazoles - pharmacology | Quinoxalines - metabolism | Pyrazoles - metabolism | Schizonts - drug effects | Drug Resistance - genetics | Animals | Models, Biological | Malaria - parasitology | Malaria - drug therapy | Plasmodium - classification | Plasma | Mosquitoes | Malaria | Licenses | Infections | Parasites | Kinases | Drug dosages
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages
Journal Article
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 430 - 9
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 2017, Volume 9, Issue 387, pp. eaad9735 - eaad9735
As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good... 
MEDICINE, RESEARCH & EXPERIMENTAL | SINGLE-DOSE CURE | IN-VITRO | TRANSMISSION | FALCIPARUM | QUANTIFICATION | DRUG DISCOVERY | KINASE INHIBITORS | DNA-SEQUENCING DATA | MALARIA PARASITES | NEXT-GENERATION | CELL BIOLOGY
Journal Article
Plos Medicine, ISSN 1549-1676, 2016, Volume 13, Issue 10, p. e1002138
Journal Article