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chemistry, multidisciplinary (8) 8
cycloaddition (7) 7
alkynes (6) 6
copper (6) 6
index medicus (6) 6
chemistry (5) 5
click chemistry (4) 4
copper-free (4) 4
cycloaddition reaction (4) 4
organic chemistry (4) 4
proteins (4) 4
reactivity (4) 4
alkine (3) 3
alkynes - chemistry (3) 3
chemistry, organic (3) 3
derivatives (3) 3
fluorine (3) 3
kinetics (3) 3
living cells (3) 3
mechanism (3) 3
pyrazoles (3) 3
sydnones - chemistry (3) 3
transformation (3) 3
1,3-dipolar cycloadditions (2) 2
[ chim.orga ] chemical sciences/organic chemistry (2) 2
antiinflammatory sydnones (2) 2
biology (2) 2
biomolecules (2) 2
chemical reactions (2) 2
chemical sciences (2) 2
chemical synthesis (2) 2
chemische biologie (2) 2
chemisches reaktionsvermögen (2) 2
click-chemie (2) 2
click-chemistry (2) 2
comminution (2) 2
conjugation (2) 2
copper - chemistry (2) 2
cyclooctynes (2) 2
design modifications (2) 2
drug delivery systems (2) 2
fishing (2) 2
fluorescence (2) 2
fluorination (2) 2
free click chemistry (2) 2
generation (2) 2
kinetik (2) 2
klick-chemie (2) 2
mesoionics (2) 2
molecular structure (2) 2
physiologie (2) 2
physiology (2) 2
promoted sydnone (2) 2
pyrazole (2) 2
pyrazoles - chemical synthesis (2) 2
pyrazoles - chemistry (2) 2
regioselectivity (2) 2
regiospecific synthesis (2) 2
research (2) 2
zerstückelung (2) 2
1,3,5-trisubstituted pyrazoles (1) 1
[ chim.anal ] chemical sciences/analytical chemistry (1) 1
[ chim.cris ] chemical sciences/cristallography (1) 1
[ sdv.bbm.bs ] life sciences [q-bio]/biochemistry, molecular biology/biomolecules [q-bio.bm] (1) 1
affinity (1) 1
amino groups (1) 1
amino-acids (1) 1
analysis (1) 1
analytical chemistry (1) 1
antisense oligonucleotides (1) 1
arctic medicine. tropical medicine (1) 1
arylglycines (1) 1
axenic amastigotes (1) 1
benzotriazoles (1) 1
bewegungsstudie (1) 1
biochemistry, molecular biology (1) 1
biologie (1) 1
biomolekül (1) 1
bioorthogonal reactions (1) 1
bioorthogonale reaktionen (1) 1
bridged bicyclo compounds - chemistry (1) 1
bromination (1) 1
care and treatment (1) 1
catalysis (1) 1
catalyst (1) 1
cells (1) 1
chemical biology (1) 1
chemical proteomics (1) 1
chemical-biology (1) 1
chemistry, physical (1) 1
cleavable linker (1) 1
cleavage (1) 1
cleavage reactions (1) 1
click (1) 1
click-reaction (1) 1
click-reaktion (1) 1
clinical trials (1) 1
complex (1) 1
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convertible nucleoside approach (1) 1
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Helvetica Chimica Acta, ISSN 0018-019X, 12/2019, Volume 102, Issue 12, p. n/a
Structural modification at the 2′‐O‐position of riboses in oligonucleotide therapeutics is of critical importance for their use as drugs. To date, the... 
spermine | oligonucleotides | convertible nucleoside approach | oligonucleotide conjugates | hybridization | MOE oligonucleotides | Drugs | Solid phase synthesis | Oligonucleotides | Clinical trials | Antisense oligonucleotides | Ribonucleic acid--RNA | Metabolism | Solid phase methods | Pyrimidines | Spermine | Affinity | Conjugation | Amino groups | Solid phases
Journal Article
Chemical Communications, ISSN 1359-7345, 10/2017, Volume 53, Issue 84, pp. 11515 - 11527
Sydnones are among the most popular mesoionic compounds studied so far for cycloaddition reactions. However, despite their good chemical stability and... 
PROMOTED SYDNONE | 1,3-DIPOLAR CYCLOADDITIONS | PYRAZOLES | REGIOSPECIFIC SYNTHESIS | MECHANISM | CLICK CHEMISTRY | REACTIVITY | FLUORINE | GENERATION | REGIOSELECTIVITY | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 10/2017, Volume 53, Issue 84, pp. 11515 - 11527
Sydnones are among the most popular mesoionic compounds studied so far for cycloaddition reactions. However, despite their good chemical stability and... 
Alkynes - chemistry | Click Chemistry | Cycloaddition Reaction | Sydnones - chemistry
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2016, Volume 55, Issue 39, pp. 12073 - 12077
We report the synthesis and reactivity of 4‐fluorosydnones, a unique class of mesoionic dipoles displaying exquisite reactivity towards both copper‐catalyzed... 
click chemistry | fluorine-18 | radiolabeling | kinetics | electrophilic fluorination | CELLS | COMPLEX | REDUCTIVE ELIMINATION | CHEMISTRY, MULTIDISCIPLINARY | SYDNONE | CYCLOADDITION | FLUORINE | COPPER-FREE | Copper | Fluorides | Kinetics
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2017, Volume 56, Issue 49, pp. 15612 - 15616
We report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two... 
click chemistry | mesoionic compounds | bioorthogonal reactions | chemical biology | cleavage reactions | LIGATION | DRUG-RELEASE | CLEAVAGE | CHEMISTRY, MULTIDISCIPLINARY | CYCLOADDITION | CONJUGATION | PEPTIDES | CHEMICAL PROTEOMICS | CHEMISTRY | PROTEINS | Proteins | Drug delivery systems | Transformation | Fishing | Design modifications | Alkynes
Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 76, pp. 10758 - 10761
Copper-catalyzed and copper-free sydnone-alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in... 
CHEMISTRY | CYCLOADDITION | CHEMISTRY, MULTIDISCIPLINARY | PROBES | Analytical chemistry | Life Sciences | Organic chemistry | Biomolecules | Biochemistry, Molecular Biology | Chemical Sciences
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2018, Volume 24, Issue 34, pp. 8535 - 8541
Emerging applications in the field of chemical biology are currently limited by the lack of bioorthogonal reactions allowing both removal and linkage of... 
mesoionics | iminosydnones | click | cleavable linker | release reactions | SYDNONE IMINES | MESOIONIC RING | CHEMISTRY, MULTIDISCIPLINARY | CYCLOADDITION | AMINO-ACIDS | DIELS-ALDER REACTION | NITRIC-OXIDE | CHEMISTRY | COPPER-FREE | DERIVATIVES | LIVING CELLS | Organic chemistry | Transformation | Reaction kinetics | Chemical reactions | Biomolecules | Kinetics | Chemical synthesis | Alkynes
Journal Article
Chemical Communications, ISSN 1359-7345, 08/2014, Volume 50, Issue 66, pp. 9376 - 9378
New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne.... 
ANTIINFLAMMATORY SYDNONES | CYCLOOCTYNES | COPPER-FREE | FREE CLICK CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 08/2014, Volume 50, Issue 66, pp. 9376 - 9378
New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne.... 
Bridged Bicyclo Compounds - chemistry | Halogens - chemistry | Proton Magnetic Resonance Spectroscopy | Cycloaddition Reaction
Journal Article
ISSN 1359-7345, 9/2018, Volume 54, Issue 76, pp. 1758 - 1761
Copper-catalyzed and copper-free sydnone-alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in... 
Journal Article
Organic Letters, ISSN 1523-7060, 01/2015, Volume 17, Issue 2, pp. 362 - 365
Copper-catalyzed cycloaddition of alkynes with 4-bromosydnones provides a convenient, mild, and regioselective method for the synthesis of a wide range of... 
ARYLGLYCINES | BROMINATION | FLUORESCENCE | LIGANDS | COMPLEXES | DRUG DESIGN | SYDNONES | CHEMISTRY | CHEMISTRY, ORGANIC | DERIVATIVES | DISCOVERY | Pyrazoles - chemistry | Copper - chemistry | Pyrazoles - chemical synthesis | Stereoisomerism | Sydnones - chemistry | Alkynes - chemistry | Molecular Structure | Catalysis | Cycloaddition Reaction
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2018, Volume 54, Issue 76, pp. 10758 - 10761
Copper-catalyzed and copper-free sydnone–alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in... 
Proteins | Organic chemistry | Cycloaddition | Fluorescence | Labelling | Chemical reactions | Copper | Coumarin | Pyrazole | Alkynes
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 12/2019, Volume 21, Issue 23, pp. 9747 - 9752
Herein we report on the development of an MS tag screening strategy that accelerates the discovery of photocatalytic reactions. By efficiently combining... 
BENZOTRIAZOLES | CHEMISTRY, ORGANIC | CATALYST | SELECTIVITY | HIGH-THROUGHPUT DISCOVERY
Journal Article
ACS Catalysis, ISSN 2155-5435, 12/2018, Volume 8, Issue 12, pp. 11882 - 11888
The chemistry and reactivity of mesoionic compounds represent a chemical space largely unexploited. Using a MS-based screening approach, the reactivity of... 
triazoles | copper | mesoionics | screening | cycloaddition | FLUOROPHORES | MECHANISM | screening triazoles | EFFICIENT SYNTHESIS | CHEMISTRY | CHEMISTRY, PHYSICAL | DERIVATIZATION | Organic chemistry | Cristallography | Chemical Sciences
Journal Article
ISSN 1359-7345, 7/2014, Volume 5, Issue 66, pp. 9376 - 9378
New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne.... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 12/2017, Volume 129, Issue 49, pp. 15818 - 15822
We report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two... 
Spaltungsreaktionen | Bioorthogonale Reaktionen | Chemische Biologie | Mesoionische Verbindungen | Klick-Chemie | Proteins | Drug delivery systems | Transformation | Fishing | Design modifications | Alkynes
Journal Article
Angewandte Chemie, ISSN 0044-8249, 09/2016, Volume 128, Issue 39, pp. 12252 - 12256
We report the synthesis and reactivity of 4‐fluorosydnones, a unique class of mesoionic dipoles displaying exquisite reactivity towards both copper‐catalyzed... 
Reaktionskinetik | Fluor-18 | Radiomarkierung | Elektrophile Fluorierung | Klick-Chemie | Copper | Kinetics | Synthesis (chemistry) | Cycloaddition | Rate constants | Dipoles | Precursors | Terminals | Fluorination | Alkynes
Journal Article
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