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science & technology (176) 176
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1. Full Text Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans
by Xu, Luang and Liu, Xinyu and Sheng, Na and Oo, Kyaw Soe and Liang, Junxin and Chionh, Yok Hian and Xu, Juan and Ye, Fuzhou and Gao, Yong-Gui and Dedon, Peter C and Fu, Xin-Yuan
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 35, pp. 14695 - 14703
Liver - enzymology | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Substrate Specificity | Serine-tRNA Ligase - chemistry | Cytidine - analogs & derivatives | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Serine-tRNA Ligase - metabolism | RNA Interference | Isoenzymes - metabolism | Mice, Mutant Strains | RNA, Transfer, Arg - metabolism | Cell Line | Methyltransferases - chemistry | RNA Processing, Post-Transcriptional | RNA, Transfer, Thr - metabolism | Isoenzymes - genetics | RNA, Transfer - metabolism | Liver - metabolism | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Animals | Methyltransferases - antagonists & inhibitors | Cytidine - metabolism | Mice | RNA, Transfer, Ser - metabolism | Mutation | Methylation | Index Medicus | Editors' Picks | mouse | Mettl2 | transfer RNA (tRNA) | Mettl6 | RNA methyltransferase | mRNA | m3C | human | mice | Mettl8
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2. Full Text The Chemical Toxicology of 2-Deoxyribose Oxidation in DNA
by Dedon, Peter C
Chemical research in toxicology, ISSN 0893-228X, 01/2008, Volume 21, Issue 1, pp. 206 - 219
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Solvents | DNA - chemistry | Animals | Models, Chemical | Oxidation-Reduction | Glutathione - metabolism | Humans | Deoxyribose - chemistry | Glutathione Transferase - metabolism | DNA Damage | RNA - drug effects | DNA - drug effects | Index Medicus
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3. Full Text Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates
by Lonkar, Pallavi and Dedon, Peter C
International journal of cancer, ISSN 0020-7136, 05/2011, Volume 128, Issue 9, pp. 1999 - 2009
nitric oxide | inflammation | DNA damage | macrophage | metabolism | superoxide | biomarker | lipid peroxidation | neutrophil | Biomarker | Nitric oxide | Lipid peroxidation | Inflammation | Superoxide | Neutrophil | Metabolism | Macrophage | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Inflammation - metabolism | Animals | Reactive Oxygen Species - metabolism | Neoplasms - genetics | Reactive Nitrogen Species - adverse effects | Cell Transformation, Neoplastic - genetics | Humans | Risk Factors | DNA Damage - genetics | Inflammation - genetics | Chronic Disease | Urine | Oxidative stress | Excretion | Oxygen | biomarkers | Leukocytes (neutrophilic) | nucleic acids | Macrophages | Nitrogen | Carcinogenesis | Blood | Risk factors | Signal transduction | biotransformation | Apoptosis | Cancer | Index Medicus
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4. Full Text Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses
by Chan, Cheryl and Pham, Phuong and Dedon, Peter C and Dedon, Peter C and Begley, Thomas J and Begley, Thomas J
Genome biology, ISSN 1474-7596, 12/2018, Volume 19, Issue 1, pp. 228 - 228
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Enzymes | Translation | tRNA | Bias | Scheduling | Gene expression | Proteins | E coli | Use statistics | Codon bias | DNA methylation | Hypoxia | Deoxyribonucleic acid--DNA | Viral infections | Transfer RNA | Index Medicus
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5. Full Text Exploring the virulence gene interactome with CRISPR / dC as9 in the human malaria parasite
by Bryant, Jessica M and Baumgarten, Sebastian and Dingli, Florent and Loew, Damarys and Sinha, Ameya and Claës, Aurélie and Preiser, Peter R and Dedon, Peter C and Scherf, Artur
Molecular systems biology, ISSN 1744-4292, 08/2020, Volume 16, Issue 8
Enrichment | Chromatin | Transcription factors | Divergence | Pathogenesis | Genes | Virulence | Erythrocytes | Genomes | Regulatory sequences | Parasites | Proteins | Var gene | Transcription activation | MORC protein | Chromosomes | Deoxyribonucleic acid--DNA | Immune system | Vector-borne diseases | CRISPR | Malaria | Structural proteins | Mass spectroscopy | Proteomics | Epigenetics | Mass spectrometry | Life Sciences | Microbiology and Parasitology | Parasitology
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6. Full Text 7-Deazaguanine modifications protect phage DNA from host restriction systems
by Hutinet, Geoffrey and Kot, Witold and Cui, Liang and Hillebrand, Roman and Balamkundu, Seetharamsingh and Gnanakalai, Shanmugavel and Neelakandan, Ramesh and Carstens, Alexander B and Lui, Chuan Fa and Tremblay, Denise and Jacobs-Sera, Deborah and Sassanfar, Mandana and Lee, Yan-Jiun and Weigele, Peter and Moineau, Sylvain and Hatfull, Graham F and Dedon, Peter C and Hansen, Lars H and de Crecy-Lagard, Valerie
Nature communications, ISSN 2041-1723, 11/2019, Volume 10, Issue 1, pp. 5442 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Guanine - metabolism | Pyrroles - metabolism | DNA Restriction Enzymes - metabolism | Guanine - analogs & derivatives | Bacteriophages - metabolism | Bacteriophages - genetics | DNA - metabolism | Pyrimidinones - metabolism | Archaeal Viruses - genetics | Enzymes | Microorganisms | Phages | Viruses | Genomes | Deoxyribonucleic acid--DNA | Intermediates | Index Medicus
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7. Full Text Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
by dos Santos, Maria C. Ferreira and Anderson, Cole P and Neschen, Susanne and Zumbrennen-Bullough, Kimberly B and Romney, Steven J and Kahle-Stephan, Melanie and Rathkolb, Birgit and Gailus-Durner, Valerie and Fuchs, Helmut and Wolf, Eckhard and Rozman, Jan and de Angelis, Martin Hrabe and Cai, Weiling Maggie and Rajan, Malini and Hu, Jennifer and Dedon, Peter C and Leibold, Elizabeth A
Nature communications, ISSN 2041-1723, 01/2020, Volume 11, Issue 1, pp. 296 - 296
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | tRNA Methyltransferases - metabolism | Glucose Intolerance - genetics | Pancreatic Neoplasms - metabolism | Proinsulin - metabolism | Unfolded Protein Response - genetics | Mice, Inbred C57BL | Homeostasis | Rats | Insulinoma - genetics | Pancreatic Neoplasms - genetics | Proinsulin - genetics | Iron - metabolism | RNA, Transfer, Lys - genetics | Mice, Knockout | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | tRNA Methyltransferases - genetics | Insulinoma - metabolism | Iron Regulatory Protein 2 - genetics | Cell Line, Tumor | Iron-Sulfur Proteins - metabolism | RNA, Transfer, Lys - metabolism | Iron Regulatory Protein 2 - metabolism | Cellular manufacture | Post-transcription | Transferrin | Nutrient deficiency | tRNA Ala | Iron and steel making | Hematology | tRNA | Neurodegenerative diseases | Secretion | Diabetes mellitus | Ferritin | Iron | Biosynthesis | Metabolism | Insulin | Beta cells | Proteins | Lysine | Clusters | Diabetes | Codons | Diabetes mellitus (non-insulin dependent) | Index Medicus
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8. Full Text Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications
by Kimura, Satoshi and Dedon, Peter C and Waldor, Matthew K
Nature chemical biology, ISSN 1552-4450, 09/2020, Volume 16, Issue 9, pp. 964 - 972
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Water-borne diseases | Spectroscopy | RNA modification | RNA editing | tRNA Ala | tRNA | Editing | Reverse transcription | Mass spectroscopy | Surveying | Environmental effects | Environmental conditions | Environmental control | Gene sequencing | E coli | Bacteria | Scientific imaging | Cytosine | Signatures | Mass spectrometry | Transfer RNA | Index Medicus
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