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1. Full Text High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
by Wagle, Nikhil and Berger, Michael F and Davis, Matthew J and Blumenstiel, Brendan and De Felice, Matthew and Pochanard, Panisa and Ducar, Matthew and Van Hummelen, Paul and MacConaill, Laura E and Hahn, William C and Meyerson, Matthew and Gabriel, Stacey B and Garraway, Levi A
Cancer discovery, ISSN 2159-8274, 01/2012, Volume 2, Issue 1, pp. 82 - 93
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Line, Tumor | Gene Dosage | Neoplasms - genetics | DNA Mutational Analysis - methods | High-Throughput Nucleotide Sequencing - methods | Humans | Index Medicus
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2. Full Text Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters
by Solis, Ernesto and Suyama, Julie A and Lazenka, Matthew F and Defelice, Louis J and Negus, S. Stevens and Blough, Bruce E and Banks, Matthew L
Scientific reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, pp. 31385 - 31385
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Xenopus | Dopamine Plasma Membrane Transport Proteins - metabolism | Oocytes - metabolism | Down-Regulation | Morpholines - administration & dosage | Nucleus Accumbens - metabolism | Morpholines - pharmacology | Phenmetrazine - pharmacology | Rats | Male | Phenmetrazine - administration & dosage | Morpholines - chemistry | Animals | Oocytes - drug effects | Molecular Structure | Dopamine - metabolism | Phenmetrazine - chemistry | Nucleus accumbens | Amphetamine | Dopamine | Addiction | Rodents | Monoamine transporter | Reinforcement | Dopamine transporter | Cocaine | Oocytes | Index Medicus
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3. Full Text Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
by Flamion, Bruno and Jayadev, Supriya and Webb, Craig P and Beushausen, Sven A and Abadie, Eric and Vidal, Jean-Marc and Blank, Melanie and Waring, Jeff and Davis, Myrtle A and Betton, Graham and Vamvakas, Spiros and Collins, Nathaniel and Dieterle, Frank and Carl, Kevin and Kasper, Peter and Senagore, Anthony and Maciulaitis, Romaldas and Laurie, David and Thompson, Aliza and Papaluca, Marisa and McDuffie, James Eric and Vonderscher, Jacky and Gu, Yi-Zhong and Xu, Nancy and Pasanen, Markku and Blomme, Eric A and Barlow, Valérie G and Taylor, William and Sultana, Stefan and Mattes, William and Prasad, Krishna and Andrews-Cleavenger, Dina and Honor, David and Rossi, Phil and Lee, Jinhe and Obert, Leslie and Troth, Sean and Guffroy, Magalie and Akunda, Jackie and Walker, Elizabeth and Goering, Peter L and Goodsaid, Federico and Robinson-Gravatt, Denise and Sistare, Frank and Sonee, Manisha and Phillips, Jonathan A and Pinches, Mark and Gerhold, David L and Suter, Laura and Lima, Beatriz Silva and Defelice, Albert F and Xiao, Shen and Hausner, Elizabeth A and Baer, William and Schipper, Matthew J and Ennulat, Daniela and Jacobson-Kram, David and Thompson, Karol L and Throckmorton, Douglas and Bounous, Denise and Harpur, Ernie and Snook, Sandra and Holder, Dan and Maurer, Gérard and Ozer, Josef S and Harlow, Patricia
Nature biotechnology, ISSN 1087-0156, 05/2010, Volume 28, Issue 5, pp. 455 - 462
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animals | Kidney - drug effects | Pharmaceutical Preparations - standards | United States | Drug-Related Side Effects and Adverse Reactions | Europe | Humans | Biomarkers, Pharmacological | Kidney - injuries | Drug Approval - legislation & jurisprudence | United States Food and Drug Administration | Care and treatment | Research | Kidney diseases | Diagnosis | Biological markers | Biomarkers | Patient safety | Federal regulation | Pharmaceutical industry | Index Medicus
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4. Full Text High‐End pH‐controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed‐batch cultures
by Gagnon, Matthew and Hiller, Gregory and Luan, Yen‐Tung and Kittredge, Amy and DeFelice, Jordy and Drapeau, Denis
Biotechnology and bioengineering, ISSN 0006-3592, 06/2011, Volume 108, Issue 6, pp. 1328 - 1337
monoclonal antibody production | fed‐batch | glucose limitation | CHO cell culture | lactate | mammalian cell culture | Fed-batch | Lactate | Mammalian cell culture | Monoclonal antibody production | Glucose limitation | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Establishment of new cell lines, improvement of cultural methods, mass cultures | Methods. Procedures. Technologies | Biological and medical sciences | Eukaryotic cell cultures | Animal cells | Cricetinae | Animals | Cricetulus | Lactic Acid - metabolism | Glucose - metabolism | Antibodies, Monoclonal - metabolism | Cell Culture Techniques - methods | CHO Cells | Hydrogen-Ion Concentration | Proteins | Cell culture | Cell growth | Approximation | Rodents | Monoclonal antibodies | Glucose | Bioengineering | Lactates | Reproduction | pH | Nutrients | Density | Culture | Index Medicus
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5. Full Text The Structure of Haplotype Blocks in the Human Genome
by Stacey B. Gabriel and Stephen F. Schaffner and Huy Nguyen and Jamie M. Moore and Jessica Roy and Brendan Blumenstiel and John Higgins and Matthew DeFelice and Amy Lochner and Maura Faggart and Shau Neen Liu-Cordero and Charles Rotimi and Adebowale Adeyemo and Richard Cooper and Ryk Ward and Eric S. Lander and Mark J. Daly and David Altshuler
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2002, Volume 296, Issue 5576, pp. 2225 - 2229
Haplotypes | Human genome | Proportions | Alleles | African Americans | Reports | Genomes | Sampling distributions | Chromosomes | African American studies | Empirical evidence | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Molecular genetics | Genes. Genome | European Continental Ancestry Group - genetics | Europe | Humans | Japan | Africa | Asian Continental Ancestry Group - genetics | Computational Biology | Genotype | Chromosome Mapping | Linkage Disequilibrium | Genetic Variation | Recombination, Genetic | China | Computer Simulation | Models, Genetic | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Genome, Human | Research | Mutation | Disease | Genomics | Genes | Index Medicus
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6. Full Text DGAT1 mutation is linked to a congenital diarrheal disorder
by Haas, Joel T and Winter, Harland S and Lim, Elaine and Kirby, Andrew and Blumenstiel, Brendan and DeFelice, Matthew and Gabriel, Stacey and Branski, David and Grueter, Carrie A and Toporovski, Mauro S and Walther, Tobias C and Daly, Mark J and Farese Jr, Robert V
The Journal of clinical investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4680 - 4684
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Genetic Association Studies | RNA Splice Sites - genetics | Humans | Cells, Cultured | Infant | Male | Diarrhea, Infantile - congenital | Animals | Diacylglycerol O-Acyltransferase - genetics | DNA Mutational Analysis | Pedigree | Fatal Outcome | Female | Mice | Diarrhea, Infantile - genetics | Protein Stability | Diarrhea, Infantile - diagnosis | Infant, Newborn | Care and treatment | Intestines | Gene mutations | Diarrhea | Genetic aspects | Birth defects | Diagnosis | Identification and classification | Index Medicus | Abridged Index Medicus | Diacylglycerol O-acyltransferase | Intestine | Mucosa | Children | Mutation | Birth | Age | DGAT1 gene | Brief Report
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7. Full Text Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer
by Parsons, Heather A and Rhoades, Justin and Reed, Sarah C and Gydush, Gregory and Ram, Priyanka and Exman, Pedro and Xiong, Kan and Lo, Christopher C and Li, Tianyu and Fleharty, Mark and Kirkner, Gregory J and Rotem, Denisse and Cohen, Ofir and Yu, Fangyan and Fitarelli-Kiehl, Mariana and Leong, Ka Wai and Hughes, Melissa E and Rosenberg, Shoshana M and Collins, Laura C and Miller, Kathy D and Blumenstiel, Brendan and Trippa, Lorenzo and Cibulskis, Carrie and Neuberg, Donna S and DeFelice, Matthew and Freeman, Samuel S and Lennon, Niall J and Wagle, Nikhil and Ha, Gavin and Stover, Daniel G and Choudhury, Atish D and Getz, Gad and Winer, Eric P and Meyerson, Matthew and Lin, Nancy U and Krop, Ian and Love, J. Christopher and Makrigiorgos, G. Mike and Partridge, Ann H and Mayer, Erica L and Golub, Todd R and Adalsteinsson, Viktor A
Clinical cancer research, ISSN 1078-0432, 06/2020, Volume 26, Issue 11, pp. 2556 - 2564
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus | breast cancer | minimal residual disease | circulating tumor DNA (ctDNA) | liquid biopsy | molecular profiling
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8. Full Text Hypothalamic mTORC2 is essential for metabolic health and longevity
by Chellappa, Karthikeyani and Brinkman, Jacqueline A and Mukherjee, Sarmistha and Morrison, Mark and Alotaibi, Mohammed I and Carbajal, Kathryn A and Alhadeff, Amber L and Perron, Isaac J and Yao, Rebecca and Purdy, Cole S and DeFelice, Denise M and Wakai, Matthew H and Tomasiewicz, Jay and Lin, Amy and Meyer, Emma and Peng, Yajing and Arriola Apelo, Sebastian I and Puglielli, Luigi and Betley, J. Nicholas and Paschos, Georgios K and Baur, Joseph A and Lamming, Dudley W
Aging cell, ISSN 1474-9718, 10/2019, Volume 18, Issue 5, pp. e13014 - n/a
mTOR | frailty | lifespanobesity | mTORC2 | hypothalamus | obesity | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Physiological aspects | Brain | Medical colleges | Kidney diseases | Protein kinases | Analysis | TOR protein | Adipose tissue | Food sources | Body fat | Homeostasis | Rapamycin | Hypothalamus | Longevity | Metabolism | Kinases | Protein turnover | Life span | Protein kinase | Aging | Fitness | Index Medicus | Original
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9. Full Text Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
by Saxena, Richa and Voight, Benjamin F and Lyssenko, Valeriya and Burtt, Noël P and De Bakker, Paul I. W and Chen, Hong and Roix, Jeffrey J and Kathiresan, Sekar and Hirschhorn, Joel N and Daly, Mark J and Hughes, Thomas E and Groop, Leif and Altshuler, David and Novartis Inst BioMedical Res and Diabet Genetics Initiative Broad In and Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2007, Volume 316, Issue 5829, pp. 1331 - 1336
Biomedical research | Introns | Medical genetics | P values | Genetic loci | Hospital units | Reports | Diabetes | Type 2 diabetes mellitus | Chromosomes | Research universities | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Haplotypes | Insulin-Like Growth Factor Binding Proteins - genetics | Genetic Predisposition to Disease | Meta-Analysis as Topic | Blood Glucose - analysis | Quantitative Trait, Heritable | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Genotype | Male | Chromosome Mapping | Genetic Markers | Case-Control Studies | Chromosomes, Human, Pair 9 - genetics | Adaptor Proteins, Signal Transducing - genetics | Alleles | Insulin Resistance - genetics | Triglycerides - blood | Female | Aged | Polymorphism, Single Nucleotide | Genome, Human | Type 2 diabetes | Genetic aspects | Research | Risk factors | Proteins | Disease prevention | Genomics | Medical treatment | Lipids | Metabolism | Index Medicus | Other Clinical Medicine | Basic Medicine | Hälsovetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Klinisk medicin | Läkemedelskemi | Medicinal Chemistry | Clinical Medicine | Endokrinologi och diabetes | Medicinska och farmaceutiska grundvetenskaper | Annan klinisk medicin | Health Sciences | Endocrinology and Diabetes
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