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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 23, pp. 9566 - 9571
Compaction and looping of the ∼2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V H genes to be brought in proximity with D H -J H... 
Immunoglobulins | Chromatin | B lymphocytes | Genes | Cell lines | Stem cells | Retroviridae | Genetic loci | Cells | Binding sites | ChIP-seq | Insulator | Boundary element | Lymphocytes | V(D)J recombination | lymphocytes | boundary element | CHROMATIN | MULTIDISCIPLINARY SCIENCES | HEAVY-CHAIN GENE | CONFORMATION | REARRANGEMENTS | IMMUNOGLOBULIN LOCI | ORGANIZATION | ELEMENTS | LYMPHOCYTE DEVELOPMENT | SWITCH | insulator | Precursor Cells, B-Lymphoid - metabolism | Phosphoproteins - metabolism | DNA, Antisense - genetics | Chromatin Immunoprecipitation | RNA Interference | Cell Cycle Proteins - genetics | Transcription, Genetic | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Cell Line | Chromosomal Proteins, Non-Histone - metabolism | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Cells, Cultured | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Binding Sites - genetics | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Chromosomal Proteins, Non-Histone - genetics | Mice, Knockout | Animals | CCCTC-Binding Factor | Immunoglobulin Heavy Chains - metabolism | Protein Binding | Enhancer Elements, Genetic - genetics | Mice | Immunoglobulin Heavy Chains - genetics | RNA, Antisense - genetics | Proteins | Signal transduction | Genomics | Viruses | Chromosomes | Biological Sciences
Journal Article
Seminars in Immunology, ISSN 1044-5323, 12/2010, Volume 22, Issue 6, p. 346
V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR).... 
Post-translational modification | Immunoglobulins | Chromatin | Lysine | DNA binding proteins
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2009, Volume 182, Issue 1, pp. 44 - 48
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 11/2008, Volume 138, Issue 11, p. 2098
  One mechanism through which bioactive food components may exert anticancer effects is by reducing the expression of the proinflammatory gene cyclooxygenase-2... 
Proteins | Nutrition | Kinases | Cells | Cancer
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 01/2009, Volume 139, Issue 1, p. 26
  Ligands of the aryl hydrocarbon receptor (AhR) include the environmental xenobiotic 2,3,7,8 tetrachlorodibenzo(p)dioxin (TCDD), polycyclic aryl hydrocarbons,... 
Genes | Dioxins | Cells | Tumors
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 11/2006, Volume 136, Issue 11, p. 2743
  Conjugated linoleic acid (CLA) has been found to exert beneficial effects on lipid profile and repress de novo fatty acid synthesis in mammary gland during... 
Proteins | Nutrition | Diet | Rodents | Gene expression | Fatty acids
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 11/2006, Volume 136, Issue 11, p. 2743
Conjugated linoleic acid (CLA) has been found to exert beneficial effects on lipid profile and repress de novo fatty acid synthesis in mammary gland during... 
Physiological aspects | Mammary glands | Linoleic acids | Research | Cattle | Health aspects
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 9/2013, Volume 191, Issue 5, pp. 2393 - 2402
A diverse antibody repertoire is formed through the rearrangement of V, D, and J segments at the immunoglobulin heavy chain ( Igh ) loci. The C57BL/6 murine... 
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 11/2008, Volume 138, Issue 11, pp. 2098 - 2105
One mechanism through which bioactive food components may exert anticancer effects is by reducing the expression of the proinflammatory gene cyclooxygenase-2... 
Nutrition and Disease
Journal Article
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 1/2009, Volume 182, Issue 1, pp. 44 - 48
Contraction of the large Igh and Ig κ loci brings all V genes, spanning >2.5 Mb in each locus, in proximity to DJ H or Jκ genes. CTCF is a transcription factor... 
Transcription Factors | B cells | Gene regulation | Gene rearrangement
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 1/2009, Volume 139, Issue 1, pp. 26 - 32
Ligands of the aryl hydrocarbon receptor (AhR) include the environmental xenobiotic 2,3,7,8 tetrachlorodibenzo(p)dioxin (TCDD), polycyclic aryl hydrocarbons,... 
Biochemical, Molecular, and Genetic Mechanisms
Journal Article
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