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Journal of Comparative Neurology, ISSN 0021-9967, 08/2018, Volume 526, Issue 12, pp. 1978 - 1990
α‐Synuclein (α‐syn) is an abundant presynaptic protein that is the primary constituent of inclusions that define Lewy body diseases (LBDs). In these... 
NACP | Lewy neurites | Lewy bodies | SNCA | Antigens | Phosphorylation | Immunoglobulins | Animal models | Serine | Fibrils | Neuropil | Synuclein | Proteins | Lysates | Autopsy | Rodents | Monoclonal antibodies | RRID P20 NS092530 | RRID R33 NS09764 | RRID R01 NS064934
Journal Article
Journal Article
Acta neuropathologica communications, ISSN 2051-5960, 11/2017, Volume 5, Issue 1, pp. 85 - 16
Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of... 
Neuroinflammation | Inclusion propagation | Leukocytes | Neurodegeneration | Microglia | SNCA | ACTIVATION | LEWY BODY | SUBSTANTIA-NIGRA | RECEPTOR 4 | NEUROSCIENCES | DEGENERATION | DOPAMINERGIC NEURODEGENERATION | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | PARKINSONS-DISEASE
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2017, Volume 105, pp. 84 - 98
Abstract Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can... 
Neurology | Aggregation | Parkinson disease | Prion | NACP | SNCA | NANOMECHANICS | PATHOLOGY | RECEPTOR 4 | NEUROSCIENCES | DEGENERATION | SEEDS | NEURONS | LEWY BODIES | PROPAGATION | PARKINSONS-DISEASE | prion | aggregation
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 09/2017, Volume 105, p. 84
Proteinaceous inclusions in neurons, composed primarily of [alpha]-synuclein, define the pathology in several neurodegenerative disorders. Neurons can... 
Nervous system diseases | Mice | Parkinson's disease | Neurons
Journal Article
FEMS Microbiology Letters, ISSN 0378-1097, 07/2017, Volume 364, Issue 14
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2011, Volume 26, Issue 3, pp. 507 - 521
Journal Article
Biology Open, ISSN 2046-6390, 2018, Volume 7, Issue 11, p. bio033852
Mitochondrial DNA mutations accumulate with age and may play a role in stem cell aging as suggested by the premature aging phenotype of mitochondrial DNA... 
Aging | Mitochondria | Pyruvate addiction | Rapamycin | AMP kinase | MTOR | mTOR
Journal Article
NeuroMolecular Medicine, ISSN 1535-1084, 9/2017, Volume 19, Issue 2, pp. 322 - 344
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra... 
Neurology | Neurosciences | Metabolic therapy | Biomedicine | Mitochondrial | Proteomics | Internal Medicine | Citric acid cycle | Amino acids | Iron | Parkinson’s disease | Alpha-synuclein | SPARE RESPIRATORY CAPACITY | OXIDATIVE STRESS | Parkinson's disease | LIPID-PEROXIDATION | NEUROBLASTOMA-CELLS | SUBSTANTIA-NIGRA | NEUROSCIENCES | COMPLEX-I | MONOAMINE-OXIDASE-B | HUMAN-BRAIN | MITOCHONDRIAL DYSFUNCTION | PARKINSONS-DISEASE | Recombinant Proteins - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Mitochondria - metabolism | Amino Acids - pharmacology | Ferrous Compounds - pharmacology | Oxygen Consumption - drug effects | Adenosine Triphosphate - metabolism | Culture Media - pharmacology | Cell Line, Tumor | Neurons - metabolism | alpha-Synuclein - genetics | Drug Evaluation, Preclinical | Neurons - drug effects | Paraquat - pharmacology | alpha-Synuclein - metabolism | Energy Metabolism - drug effects | Neuroblastoma - pathology | Medical colleges | Nervous system diseases | Neurons | Dietary supplements | Proline | Sulfates | Citric acid | Proteins | Production management | Iron compounds | Metabolites | Analysis | Physiological aspects | Glutamine | Adaptations | Tricarboxylic acid cycle | Iron sulfates | Brain | Energy metabolism | Neuroblastoma | Synuclein | Neuroblastoma cells | Electron transport chain | Mitochondria | Movement disorders | Dopamine receptors | Oxygen | Dopamine | Ferrous sulfate | Neurodegenerative diseases | Oxygen consumption | Abundance | Metabolism | L-Proline | Intermediates | Valine | Paraquat | L-Serine | L-Valine | Electron transport
Journal Article
JOURNAL OF COMPARATIVE NEUROLOGY, ISSN 0021-9967, 08/2018, Volume 526, Issue 12, pp. 1978 - 1990
alpha-Synuclein (-syn) is an abundant presynaptic protein that is the primary constituent of inclusions that define Lewy body diseases (LBDs). In these... 
THIOFLAVIN-T | DEMENTIA | NACP | SERINE 129 | NEURODEGENERATION | PATHOLOGY | NEUROSCIENCES | Lewy bodies | FIBRILS | ZOOLOGY | PHOSPHORYLATED ALPHA-SYNUCLEIN | Lewy neurites | PROGRESSION | SNCA | PARKINSONS-DISEASE | Proteins | Monoclonal antibodies | Analysis
Journal Article
01/2015, ISBN 9781339007687
Mitochondrial dysfunction plays a pivotal role in the development of aging phenotypes and aging-associated neurodegenerative disorders, such as Alzheimer’s... 
Neurosciences | Cellular biology | Molecular biology
Dissertation
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 09/2017, Volume 8, pp. 508 - 519
No treatments exist to slow or halt Parkinson’s disease (PD) progression; however, inhibition of leucine-rich repeat kinase 2 (LRRK2) activity represents one... 
Parkinson's disease | preformed fibrils | LRRK2 | α-synuclein | antisense oligonucleotides | Tyrosine | Phenotypes | Kidneys | Disease | Neurodegenerative diseases | Neurons | Hydroxylase | Fibrils | Antisense oligonucleotides | FDA approval | Leucine | Tyrosine 3-monooxygenase | Wire | Synuclein | Kinases | Proteins | Mutation | LRRK2 protein | Movement disorders
Journal Article
Neuropharmacology, ISSN 0028-3908, 12/2012, Volume 63, Issue 8, pp. 1368 - 1379
Caffeine and melatonin have been shown to protect the Swedish mutant amyloid precursor protein (APP ) transgenic mouse model of Alzheimer's disease from... 
Melatonin | Mitochondrial | Mice | Alzheimer's disease | Melatonin receptor | Caffeine | Phosphodiesterase | BETA-AMYLOID PEPTIDES | FIREFLY LUCIFERASE | COGNITIVE IMPAIRMENT | AXONAL-TRANSPORT | DISEASE IMPLICATIONS | TRANSGENIC MODEL | NEUROSCIENCES | DECREASED MT1 | ADENOSINE RECEPTORS | SUPRACHIASMATIC NUCLEUS | MOUSE MODEL | PHARMACOLOGY & PHARMACY | Central Nervous System Stimulants - pharmacology | Reactive Oxygen Species - metabolism | Mitochondrial Diseases - metabolism | Melatonin - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Alzheimer Disease - pathology | Transfection | Adenosine Triphosphate - metabolism | Amyloid beta-Protein Precursor - metabolism | Caffeine - pharmacology | Neurons - drug effects | Cyclic AMP - metabolism | Mitochondrial Diseases - drug therapy | Phosphoric Diester Hydrolases - metabolism | Enzyme-Linked Immunosorbent Assay | Cells, Cultured | Phosphodiesterase Inhibitors - pharmacology | Mice, Transgenic | Antioxidants - pharmacology | Mitochondria - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Oxygen Consumption - drug effects | In Vitro Techniques | Melatonin - pharmacology | Analysis | Amyloid beta-protein | Mitochondrial DNA | Universities and colleges | Cells | Indexing in process
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 09/2017, Volume 8, pp. 508 - 519
No treatments exist to slow or halt Parkinson's disease (PD) progression; however, inhibition of leucine-rich repeat kinase 2 (LRRK2) activity represents one... 
Parkinson's disease | preformed fibrils | LRRK2 | α-synuclein | antisense oligonucleotides | MEDICINE, RESEARCH & EXPERIMENTAL | INTERPLAY | FIBRILS | GENETICS |