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1. FDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer
by Lovinfosse, Pierre and Polus, Marc and Van Daele, Daniel and Martinive, Philippe and Daenen, Frédéric and Hatt, Mathieu and Visvikis, Dimitris and Koopmansch, Benjamin and Lambert, Frédéric and Coimbra, Carla and Seidel, Laurence and Albert, Adelin and Delvenne, Philippe and Hustinx, Roland
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 03/2018, Volume 45, Issue 3, pp. 365 - 375
Purpose The aim of this study was to investigate the prognostic value of baseline F-18-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC).... 
Tumor heterogeneity | Rectal cancer | F-FDG PET/CT | Textural analysis | Radiomics | NEOADJUVANT CHEMORADIATION THERAPY | TEXTURAL FEATURES | UPTAKE HETEROGENEITY | F-18-FDG PET/CT | PREOPERATIVE CHEMORADIOTHERAPY | PATHOLOGICAL COMPLETE RESPONSE | RADIATION-THERAPY | CELL LUNG-CANCER | F-18-FDG PET | COLORECTAL-CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Prognosis | Humans | Middle Aged | Male | Chemoradiotherapy | Rectal Neoplasms - radiotherapy | Positron Emission Tomography Computed Tomography | Rectal Neoplasms - diagnostic imaging | Disease-Free Survival | Image Processing, Computer-Assisted | Aged, 80 and over | Adult | Female | Fluorodeoxyglucose F18 | Neoadjuvant Therapy | Aged | Retrospective Studies | Rectal Neoplasms - drug therapy | Regional analysis | Colorectal cancer | Regression analysis | Metabolism | Patients | Survival | Texture | K-Ras protein | Quality | Surgery | Rectum | Glycolysis | Homogeneity | Remission | Fatalities | Coarseness | Mutation | Positron emission tomography | Cancer
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2. Full Text Soluble factors regulated by epithelial–mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment
by Suarez‐Carmona, Meggy and Bourcy, Morgane and Lesage, Julien and Leroi, Natacha and Syne, Laïdya and Blacher, Silvia and Hubert, Pascale and Erpicum, Charlotte and Foidart, Jean‐Michel and Delvenne, Philippe and Birembaut, Philippe and Noël, Agnès and Polette, Myriam and Gilles, Christine
The Journal of Pathology, ISSN 0022-3417, 08/2015, Volume 236, Issue 4, pp. 491 - 504
Epithelial–mesenchymal transition ( EMT ) programmes provide cancer cells with invasive and survival capacities that might favour metastatic dissemination.... 
epithelial–mesenchymal transition | cancer | myeloid cells | angiogenesis | epithelial-mesenchymal transition | TGF-BETA | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | PATHOLOGY | INTERLEUKIN-8 | INVASION | ONCOLOGY | CANCER METASTASIS | GROWTH | STEM-CELL | EXPRESSION | CARCINOMA | SNAIL | Angiogenic Proteins - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Tumor Microenvironment | Transfection | RNA Interference | Epithelial-Mesenchymal Transition | Triple Negative Breast Neoplasms - pathology | Female | Cytokines - genetics | Cytokines - metabolism | Paracrine Communication | Signal Transduction | Mice, Inbred C57BL | Rats | Triple Negative Breast Neoplasms - blood supply | Mice, SCID | Chemotaxis | Phenotype | Animals | Triple Negative Breast Neoplasms - genetics | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Myeloid Cells - metabolism | Myeloid Cells - pathology | Angiogenic Proteins - metabolism | Culture Media, Conditioned - metabolism | Index Medicus
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3. Full Text Surveillance of effects of HPV vaccination in Belgium
by Arbyn, Marc and Broeck, Davy Vanden and Benoy, Ina and Bogers, Johannes and Depuydt, Christophe and Praet, Marleen and Sutter, Philippe De and Hoorens, Anne and Hauben, Esther and Poppe, Willy and Ranst, Marc Van and Delvenne, Philippe and Gofflot, Stephanie and Pétein, Michel and Engelen, Frans and Vanneste, Alain and Beeck, Lode Op De and Damme, Pierre Van and Temmerman, Marleen and Weyers, Steven
Cancer Epidemiology, ISSN 1877-7821, 2016, Volume 41, pp. 152 - 158
Highlights • Enrolling continuous series of cytological specimens enriched with pathological samples from women attending cervical cancer screening provides,... 
Hematology, Oncology and Palliative Medicine | Internal Medicine | Screening | Human papillomavirus | Surveillance | HPV vaccination | Cervical cancer | HPV | EFFICACY | CERVICAL-CANCER | PREVALENCE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ONCOLOGY | PAPILLOMAVIRUS | INFECTION | YOUNG-WOMEN | Belgium - epidemiology | Humans | Middle Aged | Papillomavirus Infections - epidemiology | Uterine Cervical Neoplasms - epidemiology | Vaccination | Uterine Cervical Neoplasms - pathology | Young Adult | Human papillomavirus 16 - isolation & purification | Human papillomavirus 18 - isolation & purification | Biopsy | Papillomavirus Infections - prevention & control | Adolescent | Adult | Female | Papillomavirus Infections - virology | Papillomavirus Vaccines - administration & dosage | Immunization | Laboratories | Colleges & universities | Vaccines | Medical screening | Index Medicus
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4. Full Text Children with autism understand indirect speech acts: Evidence from a semi-structured act-out task
by Kissine, Mikhail and Cano-Chervel, Julie and Carlier, Sophie and De Brabanter, Philippe and Ducenne, Lesley and Pairon, Marie-Charlotte and Deconinck, Nicolas and Delvenne, Véronique and Leybaert, Jacqueline
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142191 - e0142191
Children with Autism Spectrum Disorder are often said to present a global pragmatic impairment. However, there is some observational evidence that... 
LANGUAGE | PRAGMATIC IMPAIRMENTS | COMPREHENSION | FALSE BELIEF | ATTRIBUTION | MIND | MULTIDISCIPLINARY SCIENCES | EXPLORATION | ADULTS | ACTION ANTICIPATION | INDIRECT REQUESTS | Language | Humans | Child, Preschool | Female | Male | Speech | Comprehension | Child | Speech Perception | Autistic Disorder - psychology | Case-Control Studies | Communication | Management | Social aspects | Autistic children | Interpersonal communication | Autism | Potatoes | Cognition & reasoning | Theory | Semantics | Children | Children & youth | Index Medicus
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5. Full Text [18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
by Withofs, Nadia and Martinive, Philippe and Vanderick, Jean and Bletard, Noëlla and Scagnol, Irène and Mievis, Frédéric and Giacomelli, Fabrice and Coucke, Philippe and Delvenne, Philippe and Cataldo, Didier and Gambhir, Sanjiv S and Hustinx, Roland
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 4/2016, Volume 43, Issue 4, pp. 654 - 662
Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade... 
Angiogenesis | Integrin | Medicine & Public Health | Rectal cancer | Orthopedics | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | RGD | PET | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Carcinoma - diagnostic imaging | Rectal Neoplasms - therapy | Integrin alphaVbeta3 - metabolism | Peptides, Cyclic | Rectal Neoplasms - diagnostic imaging | Multimodal Imaging | Carcinoma - therapy | Female | Aged | Rectal Neoplasms - pathology | Carcinoma - pathology | Radiopharmaceuticals | Index Medicus
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6. Full Text [^sup 18^F]FPRGD^sub 2^ PET/CT imaging of integrin [alpha]^sub v^[beta]^sub 3^ levels in patients with locally advanced rectal carcinoma
by Nadia Withofs and Philippe Martinive and Jean Vanderick and Noëlla Bletard and Irène Scagnol and Frédéric Mievis and Fabrice Giacomelli and Philippe Coucke and Philippe Delvenne and Didier Cataldo and Sanjiv S Gambhir and Roland Hustinx
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 04/2016, Volume 43, Issue 4, p. 654
  Purpose Our primary objective was to determine if [^sup 18^F]FPRGD^sub 2^ PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict... 
Angiogenesis | Medical imaging | Colorectal cancer | Tomography
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7. Full Text [18F]FPRGD.sub.2 PET/CT imaging of integrin [alpha].sub.v[beta].sub.3 levels in patients with locally advanced rectal carcinoma
by Withofs, Nadia and Martinive, Philippe and Vanderick, Jean and Bletard, Noella and Scagnol, Irene and Mievis, Frederic and Giacomelli, Fabrice and Coucke, Philippe and Delvenne, Philippe and Cataldo, Didier and Gambhir, Sanjiv S and Hustinx, Roland
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 04/2016, Volume 43, Issue 4, p. 654
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00259-015-3219-y Our... 
Care and treatment | PET imaging | Colorectal cancer | Integrins
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8. Full Text [ super(18)F]FPRGD sub(2) PET/CT imaging of integrin alpha sub(v) beta sub(3) levels in patients with locally advanced rectal carcinoma
by Withofs, Nadia and Martinive, Philippe and Vanderick, Jean and Bletard, Noeella and Scagnol, Irene and Mievis, Frederic and Giacomelli, Fabrice and Coucke, Philippe and Delvenne, Philippe and Cataldo, Didier and Gambhir, Sanjiv S and Hustinx, Roland
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 04/2016, Volume 43, Issue 4, pp. 654 - 662
Our primary objective was to determine if [ super(18)F]FPRGD sub(2) PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour... 
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9. Full Text Transforming growth factor beta‐induced, an extracellular matrix interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration
by Costanza, Brunella and Rademaker, Gilles and Tiamiou, Assia and De Tullio, Pascal and Leenders, Justine and Blomme, Arnaud and Bellier, Justine and Bianchi, Elettra and Turtoi, Andrei and Delvenne, Philippe and Bellahcène, Akeila and Peulen, Olivier and Castronovo, Vincent
International Journal of Cancer, ISSN 0020-7136, 09/2019, Volume 145, Issue 6, pp. 1570 - 1584
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly malignancy with no efficient therapy available up‐to‐date. Glycolysis is the main provider of... 
TGFBI | integrin | pancreas | extracellular matrix | glycolysis | METASTASIS | INITIATION | ONCOGENIC KRAS | ADENOCARCINOMA | MAINTENANCE | ONCOLOGY | GLUCOSE-METABOLISM | BETA-IG-H3 | FOCAL ADHESION KINASE | INDUCED TGFBI | PROGRESSION | Glucose metabolism | Analysis | Pancreatic cancer | Heat shock proteins | Development and progression | Metastasis | Gene expression | Integrins | Adenocarcinoma | Phenotypes | Invasiveness | Transforming growth factor-b | Malignancy | Kinases | Substrates | Cell adhesion & migration | Proteins | Signal transduction | Chorioallantoic membrane | Stromal cells | Glycolysis | Extracellular matrix | Focal adhesion kinase | Growth factors | Cell migration | Cancer
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10. Full Text Myoferlin plays a key role in VEGFA secretion and impacts tumor‐associated angiogenesis in human pancreas cancer
by Fahmy, Karim and Gonzalez, Arnaud and Arafa, Mohammad and Peixoto, Paul and Bellahcène, Akeila and Turtoi, Andrei and Delvenne, Philippe and Thiry, Marc and Castronovo, Vincent and Peulen, Olivier
International Journal of Cancer, ISSN 0020-7136, 02/2016, Volume 138, Issue 3, pp. 652 - 663
Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a... 
myoferlin | exocytosis | VEGF | angiogenesis | pancreas ductal adenocarcinoma | CELLS | MEMBRANE-REPAIR | DUCTAL ADENOCARCINOMA | PHASE-II | HIGH EXPRESSION | MYOBLAST FUSION | C2 DOMAINS | IN-VITRO | ONCOLOGY | POOR-PROGNOSIS | ENDOTHELIAL GROWTH-FACTOR | Adenocarcinoma - pathology | Cell Proliferation | Carcinoma, Pancreatic Ductal - secretion | Calcium-Binding Proteins - analysis | Humans | Pancreatic Neoplasms - blood supply | Pancreatic Neoplasms - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - analysis | Vascular Endothelial Growth Factor A - analysis | Carcinoma, Pancreatic Ductal - pathology | Neovascularization, Pathologic - etiology | Membrane Proteins - analysis | Adenocarcinoma - blood supply | Vascular Endothelial Growth Factor A - secretion | Membrane Proteins - physiology | Calcium-Binding Proteins - physiology | Muscle Proteins - analysis | Cell Line, Tumor | Adenocarcinoma - secretion | Carcinoma, Pancreatic Ductal - blood supply | Muscle Proteins - physiology | Vascular endothelial growth factor | Pancreatic cancer | Kinases | Medical prognosis | Tumors | Index Medicus
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11. Full Text Women's skin throughout lifetime
by Piérard, Gérald E and Charlier, Corinne and Delvenne, Philippe and Humbert, Philippe and Piérard-Franchimont, Claudine
BioMed Research International, ISSN 2314-6133, 2014, Volume 2014, pp. 328981 - 3
MEDICINE, RESEARCH & EXPERIMENTAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Women | Skin - anatomy & histology | Humans | Skin Diseases | Female | Sex Characteristics | Skin - pathology | Index Medicus
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12. Drug Interactions with Normal and TEN Epidermal Keratinocytes
by Paquet, Philippe and Delvenne, Philippe and Piérard, Gérald E
Current Drug Safety, ISSN 1574-8863, 2012, Volume 7, Issue 5, pp. 352 - 356
Human epidermal keratinocytes (EKs) are metabolically involved in various drug transport mechanisms, as well as in detoxification or activation processes. The... 
Toxic epidermal necrolysis | Drug disposition | Cytochrome p450 | Biotransformation | Drug metabolism | Keratinocyte | Anti-transport mechanism
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13. Full Text Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer
by Maris, Pamela and Blomme, Arnaud and Palacios, Ana Perez and Costanza, Brunella and Bellahcène, Akeila and Bianchi, Elettra and Gofflot, Stephanie and Drion, Pierre and Trombino, Giovanna Elvi and Di Valentin, Emmanuel and Cusumano, Pino G and Maweja, Sylvie and Jerusalem, Guy and Delvenne, Philippe and Lifrange, Eric and Castronovo, Vincent and Turtoi, Andrei
PLoS Medicine, ISSN 1549-1277, 09/2015, Volume 12, Issue 9, pp. e1001871 - e1001871
Breast cancer is a leading malignancy affecting the female population worldwide. Most morbidity is caused by metastases that remain incurable to date. TGF-β1... 
Fibroblasts - secretion | Interleukin-1beta - pharmacology | Prognosis | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Extracellular Matrix Proteins - pharmacology | Fibroblast Growth Factors - pharmacology | Breast Neoplasms - drug therapy | Blotting, Western | Breast Neoplasms - metabolism | Fibroblast Growth Factors - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Heterografts | Survival Analysis | Biomarkers, Tumor - metabolism | Female | Mice | Retrospective Studies | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Extracellular Matrix Proteins - metabolism | Index Medicus
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14. Full Text HMGB1 secretion during cervical carcinogenesis promotes the acquisition of a tolerogenic functionality by plasmacytoid dendritic cells
by Demoulin, Stéphanie and Herfs, Michael and Somja, Joan and Roncarati, Patrick and Delvenne, Philippe and Hubert, Pascale
International Journal of Cancer, ISSN 0020-7136, 07/2015, Volume 137, Issue 2, pp. 345 - 358
Acquisition of an impaired functionality by plasmacytoid dendritic cells (pDCs) contributing to cancer progression has been documented in different types of... 
tolerogenicity | Treg cells | plasmacytoid dendritic cells | cervical cancers | HMGB1 | BREAST-CANCER PROGRESSION | OVARIAN-CANCER | LANGERHANS CELLS | UTERINE CERVIX | INTERFERON-ALPHA | ONCOLOGY | (PRE)NEOPLASTIC LESIONS | REGULATORY T-CELLS | PROTEIN HMGB1 | EXPRESSION | IFN-ALPHA | Forkhead Transcription Factors - immunology | Immunohistochemistry | T-Lymphocytes, Regulatory - metabolism | Cervix Uteri - metabolism | Coculture Techniques | Dendritic Cells - immunology | Humans | Toll-Like Receptor 9 - genetics | HMGB1 Protein - immunology | T-Lymphocytes, Regulatory - immunology | Toll-Like Receptor 9 - immunology | Forkhead Transcription Factors - metabolism | HMGB1 Protein - metabolism | Cervix Uteri - pathology | Female | Dendritic Cells - metabolism | Chemokines - immunology | Interferon-alpha - metabolism | Carcinogenesis - immunology | Intercellular Signaling Peptides and Proteins | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Keratinocytes - immunology | Interferon-alpha - immunology | Carcinogenesis - pathology | Tumor Microenvironment - immunology | Cell Differentiation - immunology | Microscopy, Confocal | Keratinocytes - pathology | Keratinocytes - metabolism | Cervix Uteri - immunology | Cell Line, Tumor | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | Dendritic cells | Development and progression | Dysplasia | Proteins | Tumorigenesis | Cervical cancer | Cells | Index Medicus
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15. Full Text Natural killer cells: Role in local tumor growth and metastasis
by Langers, Inge and Renoux, Virginie M and Thiry, Marc and Delvenne, Philippe and Jacobs, Nathalie
Biologics: Targets and Therapy, ISSN 1177-5475, 2012, Volume 6, Issue default, pp. 73 - 82
Summarises natural killer (NK) cell mechanisms to kill cancer cells, their role in host immune responses against tumour growth or metastasis, and their... 
Cytotoxicity | Tumor | Natural cytotoxicity receptor | Natural killer | Killer cells | Antineoplastic agents | Immunotherapy | Cancer | Physiological aspects | Research | Metastasis | Growth | Tumors | natural cytotoxicity receptor | natural killer | Review | tumor | cytotoxicity
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16. Full Text Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis
by Josse, Claire and Bouznad, Nassim and Geurts, Pierre and Irrthum, Alexandre and Huynh-Thu, Vân Anh and Servais, Laurence and Hego, Alexandre and Delvenne, Philippe and Bours, Vincent and Oury, Cécile
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 02/2014, Volume 306, Issue 3, pp. G229 - G243
Inflammation can contribute to tumor formation; however, markers that predict progression are still lacking. In the present study, the well-established... 
microRNA | Inflammation | Mouse model | Colorectal cancer | Computational analyses | CELLS | PHYSIOLOGY | colorectal cancer | mouse model | CANCER-RELATED INFLAMMATION | DYSPLASIA | EXPRESSION PROFILES | MOUSE COLON TUMORS | RECTAL-CANCER | EXPERIMENTAL COLITIS | inflammation | GROWTH | DYSREGULATION | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | computational analyses | Dextran Sulfate | Colonic Neoplasms - genetics | Colitis - genetics | Mice, Inbred C57BL | Colitis - pathology | Male | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Signal Transduction - genetics | Carcinogenesis - metabolism | Azoxymethane - adverse effects | Colonic Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Animals | Colitis - chemically induced | Colonic Neoplasms - pathology | Colitis - metabolism | Signal Transduction - physiology | Mice | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | MicroRNA | Oncology, Experimental | Physiological aspects | Research | Carcinogenesis | Cancer | Inflammatory bowel disease | Phosphorylation | Cellular biology | MicroRNAs | Gene expression | Tumors | Index Medicus
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17. Full Text A laser microdissection-based workflow for FFPE tissue microproteomics: Important considerations for small sample processing
by Longuespée, Rémi and Alberts, Deborah and Pottier, Charles and Smargiasso, Nicolas and Mazzucchelli, Gabriel and Baiwir, Dominique and Kriegsmann, Mark and Kriegsmann, Jörg and Herfs, Michael and Delvenne, Philippe and De Pauw, Edwin
Methods, ISSN 1046-2023, 07/2016, Volume 104, pp. 154 - 162
Proteomic methods are today widely applied to formalin-fixed paraffin-embedded (FFPE) tissue samples for several applications in research, especially in... 
Biomarkers | Mass spectrometry | Laser microdissection | Formalin fixed paraffin embedded | Proteomics | Cancer | BETA-TUBULIN | IMAGING MASS-SPECTROMETRY | ANTIGEN RETRIEVAL | DIFFERENTIAL-DIAGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | DOWN-REGULATION | NEGATIVE BREAST-CANCER | PROTEOMIC ANALYSIS | PARAFFIN-EMBEDDED TISSUES | FC BINDING-PROTEIN |