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Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 02/2012, Volume 16, Issue 2, pp. 237 - 248
•  Introduction •  Tyrosine kinase inhibitors •  Fusion gene structure and expression •  Loss of wild‐type alleles •  Oligomerization triggers TK activation • ... 
receptor tyrosine kinase | chromosomal translocations | kinase inhibitors | BCR‐ABL | Receptor tyrosine kinase | Kinase inhibitors | BCR-ABL | Chromosomal translocations | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PROTEIN | TEL-PDGFR-BETA | CELL BIOLOGY | SH2 DOMAIN | MYELOPROLIFERATIVE DISEASE | JUXTAMEMBRANE DOMAIN | ACUTE LYMPHOBLASTIC-LEUKEMIA | MYELOID-LEUKEMIA | TRANSFORMING PROPERTIES | Signal Transduction | Humans | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Neoplasms - drug therapy | Gene Fusion - genetics | Fusion Proteins, bcr-abl - genetics | Neoplasms - therapy | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Benzamides | Molecular Targeted Therapy - methods | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyrazoles - pharmacology | BCR protein | Phosphorylation | Transcription | Leukemia | Genes | Lysosomes | Clinical trials | Activation | Chaperones | Kinases | Chromosome rearrangements | Inactivation | Recruitment | Degradation | Proteins | Signal transduction | Allosteric properties | Ret protein | Clonal deletion | Janus kinase 2 | Remission | miRNA | Fusion protein | Localization | Fibroblast growth factor receptor 1 | Growth factors | Protein-tyrosine kinase | Tyrosine | Imatinib | Oligomerization | Deactivation | Gene expression | Domains | Signaling | Chromosome translocations | Adenosine kinase | Proteasomes | Syk protein | Solid tumors | Mutation | ATP | Tumors | Cancer | Review
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 01/2015, Volume 19, Issue 1, pp. 239 - 248
Platelet‐derived growth factors (PDGF) bind to two related receptor tyrosine kinases, which are encoded by the PDGFRA and PDGFRB genes. Recently, heterozygous... 
PDGFRB | receptor degradation | imatinib | brain calcification | Fahr disease | STAT3 | Brain calcification | Imatinib | Receptor degradation | MEDICINE, RESEARCH & EXPERIMENTAL | FACTOR BETA-RECEPTOR | ACTIVATION | SLC20A2 | TYROSINE KINASE | TRANSDUCTION | PHOSPHOLIPASE A | ENDOCYTOSIS | BRAIN CALCIFICATIONS | CELL BIOLOGY | GENE | TUMOR-GROWTH | Calcinosis - genetics | Phospholipase C gamma - metabolism | Humans | Mutant Proteins - metabolism | Neurodegenerative Diseases - genetics | Signal Transduction - genetics | Mutation - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Proteolysis - drug effects | Signal Transduction - drug effects | Basal Ganglia Diseases - genetics | HEK293 Cells | Cell Line, Tumor | Proto-Oncogene Proteins c-sis - pharmacology | STAT3 Transcription Factor - metabolism | Amino Acid Substitution | Calcification | Genetic aspects | Platelet-derived growth factor | Phosphotransferases | Phosphorylation | Rodents | Pharmacology | Mutation | Kinases | Neurological disorders | Calcification (ectopic) | Basal ganglia | Transcription | Genes | Smooth muscle | AKT protein | Signal transduction | Cell growth | Blood-brain barrier | Growth factors | Tyrosine | Immunoglobulins | Stat3 protein | Patients | Ganglia | Phospholipase C | Neurological diseases | Phospholipase | Signaling | Mutagenesis | Ligands | Cancer | Polymorphism | Tumors | Original
Journal Article
The FASEB Journal, ISSN 0892-6638, 09/2018, Volume 32, Issue 12, pp. 6681 - 6693
ABSTRACT The gut microbiota regulates key hepatic functions, notably through the production of bacterial metabolites that are transported via the portal... 
gut-liver axis | cholesterol metabolism | LPS | Kupffer cells | PCLS | Gut–liver axis | Cholesterol metabolism | CHOLESTEROL | TRYPTOPHAN-METABOLITES | HIGH-FAT DIET | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | HOST | CELL BIOLOGY | INDOXYL SULFATE | ARYL-HYDROCARBON RECEPTOR | DISEASE | BIOLOGY | EXPRESSION | OXYSTEROLS | Research | gut–liver axis
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 10/2013, Volume 17, Issue 10, pp. 1218 - 1235
Journal Article
Gut, ISSN 0017-5749, 02/2018, Volume 67, Issue 2, pp. 271 - 283
ObjectiveTo investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker of cardiovascular diseases, in an original mouse... 
BILE ACID METABOLISM | INTESTINAL MICROBIOLOGY | PREBIOTIC | CARDIOVASCULAR DISEASE | ENDOCRINE HORMONES | ACID | GLP-1 | DIET | GLUCOSE | AKKERMANSIA-MUCINIPHILA | NITRIC-OXIDE | WEIGHT-LOSS | ATHEROSCLEROSIS | OBESE | GASTROENTEROLOGY & HEPATOLOGY | CARDIOVASCULAR RISK | Mesenteric Arteries - physiology | Bile Acids and Salts - blood | Gene Expression - drug effects | Bacteria - drug effects | Glucagon-Like Peptide 1 - biosynthesis | Endothelium, Vascular - drug effects | Male | Cecum - microbiology | Fructans - pharmacology | Vasodilation | Organic Anion Transporters, Sodium-Dependent - genetics | Fatty Acids, Omega-3 - deficiency | Antimicrobial Cationic Peptides - genetics | Disease Models, Animal | Fatty Acids, Omega-3 - administration & dosage | Aminopeptidases - genetics | Bile Acids and Salts - biosynthesis | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Mice, Knockout, ApoE | Prebiotics | Neurotensin - genetics | Animals | Gastrointestinal Microbiome - drug effects | Symporters - genetics | Carotid Arteries - physiology | Mice | Nitric Oxide Synthase - metabolism | Proglucagon - genetics | Nitric Oxide - metabolism | Dietary Supplements | rRNA 16S | Peptides | Glucagon | Polyunsaturated fatty acids | Liver | Microbiota | Metabolites | Apolipoprotein E | Rodents | Inulin | Physiology | Supplementation | Carotid artery | Glucagon-like peptide 1 | Obesity | Preservation | Dietary supplements | Abundance | Gene expression | Apolipoproteins | Fatty acids | Endothelium | Steatosis | Weight control | Diet | Nitric oxide | Diabetes | Cardiovascular diseases | Metabolic disorders | Veins & arteries | Gut Microbiota | 1506
Journal Article