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Biochemical journal, ISSN 1470-8728, 06/2007, Volume 405, Issue 1, pp. 11 - 19
During apoptosis, the initiator caspase 9 is activated at the apoptosome after which it activates the executioner caspases 3 and 7 by proteolysis. During this... 
Caspase 3 | Feedback loop | Caspase 9 | Second mitochondrial activator of caspases (Smac) | X-linked inhibitor of apoptosis protein (XIAP) | Apoptosis | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Caspase 9 - genetics | Caspase 9 - metabolism | Humans | Caspase 3 - metabolism | Peptides - genetics | Cysteine Proteinase Inhibitors - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Recombinant Proteins - genetics | Caspase Inhibitors | Thermodynamics | Peptides - metabolism | Mitochondrial Proteins - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Amino Acid Chloromethyl Ketones - metabolism | Aspartic Acid - metabolism | Apoptosis - physiology | Enzyme Activation | Intracellular Signaling Peptides and Proteins - genetics | Index Medicus | second mitochondrial activator of caspases (Smac) | CARD, caspase recruitment domain | ITC, isothermal titration calorimetry | apoptosis | MVPI, Met-Val-Pro-Ile | bEVD-aomk, biotinylhexanoyl-Asp-Glu-Val-acyloxymethane | caspase 3 | Afc, 7-amido-4-fluoromethylcoumarin | DTT, dithiothreitol | IAP, inhibitor of apoptosis protein | feedback loop | caspase 9 | HRP, horseradish peroxidase | Z-VAD-fmk, benzyloxycarbonyl-Val-Ala-Asp-fluoromethane | AVPI, Ala-Val-Pro-Ile | BIR, baculoviral inhibitory repeat | Smac, second mitochondrial activator of caspases | ICAD, inhibitor-of-caspase-activated DNAse | ABP, affinity-based probe | Apaf-1, apoptotic protease activating factor 1 | pNA, p-nitroanilide | cyt c, cytochrome c | XIAP, X-linked IAP | IBM, IAP-binding motif | His6, hexahistidine
Journal Article
Journal Article
Journal Article
The EMBO journal, ISSN 0261-4189, 02/2005, Volume 24, Issue 3, pp. 645 - 655
Journal Article