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1. Full Text Reducing Adverse Effects During Drug Development: The Example of Lesogaberan and Paresthesia
by Rydholm, Hans, MD, PhD and von Corswant, Christian, PhD and Denison, Hans, MD, PhD and Jensen, Jörgen M., PhD and Lehmann, Anders, PhD and Ruth, Magnus, MD, PhD and Söderlind, Erik, PhD and Aurell-Holmberg, Ann, M Med Sci and Institute of Neuroscience and Physiology and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar and Sahlgrenska akademin and Institute of Clinical Sciences, Department of Otorhinolaryngology and Institutionen för neurovetenskap och fysiologi
Clinical therapeutics, ISSN 0149-2918, 2016, Volume 38, Issue 4, pp. 946 - 960
Internal Medicine | Medical Education | γ-aminobutyric acid (GABA)B receptor agonist | paresthesia | adverse effect | lesogaberan | formulation development | gastroesophageal reflux disease | γ-aminobutyric acid (GABA) | receptor agonist | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | GABA-A Receptor Agonists - therapeutic use | GABA-A Receptor Agonists - adverse effects | Propylamines - therapeutic use | Humans | Phosphinic Acids - therapeutic use | Phosphinic Acids - adverse effects | Gastroesophageal Reflux - drug therapy | Paresthesia - chemically induced | Propylamines - adverse effects | Gastroesophageal reflux | GABA | Complications and side effects | Medicine, Experimental | Medical research | Development and progression | Hypothesis testing | Formulations | Signs and symptoms | Fractionation | Esophageal sphincter | Medical treatment | Clinical trials | Pharmacology | Paresthesia | Sphincter | Dosage | Drug development | Patients | Esophagus | Literature reviews | Studies | Side effects | γ-Aminobutyric acid | Hypotheses | Pharmaceutical industry | Drug dosages | Index Medicus | gamma-aminobutyric acid (GABA)(B) receptor agonist | controlled-trial | gastroesophageal-reflux disease | agonist | Klinisk medicin | volunteers | esophageal sphincter relaxations | adverse-effect | symptoms | Clinical Medicine | inhibitor therapy | pump | mechanism
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2. Full Text Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial
by Amarenco, Pierre, Prof and Albers, Gregory W, Prof and Denison, Hans, MD and Easton, J Donald, Prof and Evans, Scott R, Prof and Held, Peter, MD and Hill, Michael D, Prof and Jonasson, Jenny, PhD and Kasner, Scott E, Prof and Ladenvall, Per, MD and Minematsu, Kazuo, Prof and Molina, Carlos A, Prof and Wang, Yongjun, Prof and Wong, K S Lawrence, Prof and Johnston, S Claiborne, Prof and SOCRATES Steering Committee and Investigators and SOCRATES Steering Comm
Lancet neurology, ISSN 1474-4422, 2017, Volume 16, Issue 4, pp. 301 - 310
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Humans | Middle Aged | Proportional Hazards Models | Atherosclerosis - complications | Male | Treatment Outcome | International Cooperation | Stroke - drug therapy | Dose-Response Relationship, Drug | Stroke - etiology | Adenosine - analogs & derivatives | Adenosine - therapeutic use | Fibrinolytic Agents - therapeutic use | Ischemic Attack, Transient - etiology | Adult | Female | Aged | Aspirin - therapeutic use | Ticagrelor | Stroke (Disease) | Prevention | Medical colleges | Aspirin | Neurosciences | Ischemia | Analysis | Cardiac patients | Clinical trials | Disease prevention | Stroke | Heart attacks | Diabetes | Thrombosis | Patients | Clinical outcomes | Index Medicus
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3. Full Text Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack
by Johnston, S. Claiborne and Amarenco, Pierre and Albers, Gregory W and Denison, Hans and Easton, J. Donald and Evans, Scott R and Held, Peter and Jonasson, Jenny and Minematsu, Kazuo and Molina, Carlos A and Wang, Yongjun and Wong, K.S. Lawrence and SOCRATES Steering Comm Investigato and SOCRATES Steering Committee and Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2016, Volume 375, Issue 1, pp. 35 - 43
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Stroke - drug therapy | Purinergic P2Y Receptor Antagonists - adverse effects | Aspirin - adverse effects | Adenosine - adverse effects | Adenosine - analogs & derivatives | Adenosine - therapeutic use | Female | Aged | Aspirin - therapeutic use | Hemorrhage - chemically induced | Platelet Aggregation Inhibitors - therapeutic use | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cerebral ischemia | Care and treatment | Aspirin | Dosage and administration | Ticagrelor | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | Intravenous administration | Transient ischemic attack | Preventive medicine | Hemorrhage | Patients | Thrombolysis | Bleeding | Ischemia | Comparative studies | Drug therapy | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | Medicin och hälsovetenskap
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4. Zahrer Wörterbuch
: Vocabolario Saurano
by Denison, Norman and Grassegger, Hans
2007, GLM, Volume 22, xx, 361
Italian | Dialects | German | German language
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5. Full Text Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial
by Shaheen, Nicholas J and Denison, Hans and Björck, Karin and Karlsson, Maria and Silberg, Debra G
Gut, ISSN 0017-5749, 09/2013, Volume 62, Issue 9, pp. 1248 - 1255
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Double-Blind Method | Esophageal Sphincter, Lower - drug effects | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Treatment Outcome | Dose-Response Relationship, Drug | Esophageal Sphincter, Lower - physiopathology | GABA-A Receptor Agonists - administration & dosage | Propylamines - administration & dosage | Proton Pump Inhibitors - administration & dosage | Adult | Female | Drug Monitoring | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy | Phosphinic Acids - administration & dosage | Gastroesophageal reflux | Protons | Stomach | Acids | Nervous system | Endoscopy | Patients | Index Medicus | Abridged Index Medicus
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6. Full Text Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA
by Johnston, S. Claiborne and Amarenco, Pierre and Denison, Hans and Evans, Scott R and Himmelmann, Anders and James, Stefan and Knutsson, Mikael and Ladenvall, Per and Molina, Carlos A and Wang, Yongjun and THALES Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2020, Volume 383, Issue 3, pp. 207 - 217
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Middle Aged | Stroke - complications | Male | Secondary Prevention | Ischemic Attack, Transient - complications | Ticagrelor - adverse effects | Aspirin - adverse effects | Aged, 80 and over | Female | Aspirin - therapeutic use | Stroke - mortality | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Ticagrelor - therapeutic use | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Disability Evaluation | Stroke - prevention & control | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Kaplan-Meier Estimate | Stroke - drug therapy | Aged | Hemorrhage - chemically induced | Stroke (Disease) | Complications and side effects | Cerebral ischemia | Aspirin | Patient outcomes | Drug therapy, Combination | Drug therapy | Ticagrelor | Testing | Cardiovascular system | Stroke | Intravenous administration | Transient ischemic attack | Clinical trials | Patients | Thrombolysis | Bleeding | Design | Magnetic resonance imaging | Ischemia | Clopidogrel | Death | Blood pressure | Index Medicus | Abridged Index Medicus
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7. Full Text A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial
by Boeckxstaens, Guy E and Beaumont, Hanneke and Hatlebakk, Jan G and Silberg, Debra G and Björck, Karin and Karlsson, Maria and Denison, Hans
Gut, ISSN 0017-5749, 09/2011, Volume 60, Issue 9, pp. 1182 - 1188
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Humans | Middle Aged | Gastrointestinal Agents - administration & dosage | Male | Young Adult | GABA-A Receptor Agonists - administration & dosage | Time Factors | Adult | Female | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy | Phosphinic Acids - administration & dosage | GABA-A Receptor Agonists - therapeutic use | Drug Administration Schedule | Phosphinic Acids - therapeutic use | Treatment Outcome | Proton Pump Inhibitors - therapeutic use | Propylamines - therapeutic use | Propylamines - administration & dosage | Epidemiologic Methods | Adolescent | Gastrointestinal Agents - therapeutic use | Aged | Gastrointestinal Agents - adverse effects | Phosphinic Acids - adverse effects | Propylamines - adverse effects | Drugs | Gastroesophageal reflux | Disease | Patients | Index Medicus | Abridged Index Medicus
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8. Full Text Impact of regurgitation on health-related quality of life in gastro-oesophageal reflux disease before and after short-term potent acid suppression therapy
by Kahrilas, Peter J and Jonsson, Andreas and Denison, Hans and Wernersson, Börje and Hughes, Nesta and Howden, Colin W
Gut, ISSN 0017-5749, 05/2014, Volume 63, Issue 5, pp. 720 - 726
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Drug Administration Schedule | Follow-Up Studies | Humans | Treatment Outcome | Heartburn - drug therapy | Proton Pump Inhibitors - therapeutic use | Esomeprazole - therapeutic use | Randomized Controlled Trials as Topic | Antacids - therapeutic use | Esophagitis, Peptic - drug therapy | Gastroesophageal Reflux - complications | Heartburn - etiology | Quality of Life | Surveys and Questionnaires | Retrospective Studies | Imidazoles - therapeutic use | Gastroesophageal Reflux - drug therapy | Esophagitis, Peptic - complications | Pyridines - therapeutic use | Esophageal diseases | Care and treatment | Research | Quality of life | Gastroesophageal reflux | Stomach | Side effects | Pneumonia | Acids | Questionnaires | Clinical medicine | Antacids | Index Medicus | Abridged Index Medicus
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9. Full Text Effects of Lesogaberan on Reflux and Lower Esophageal Sphincter Function in Patients With Gastroesophageal Reflux Disease
by Boeckxstaens, Guy E and Beaumont, Hanneke and Mertens, Veerle and Denison, Hans and Ruth, Magnus and Adler, John and Silberg, Debra G and Sifrim, Daniel
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 139, Issue 2, pp. 409 - 417
Gastroenterology and Hepatology | Transient Lower Esophageal Sphincter Relaxation | Partial Response | AZD3355 | Reflux Inhibitor | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Esophageal pH Monitoring | GABA Agonists - administration & dosage | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | GABA Agonists - adverse effects | Male | GABA Agonists - therapeutic use | Netherlands | Time Factors | Postprandial Period | Adult | Female | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy | Phosphinic Acids - administration & dosage | Manometry | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Esophageal Sphincter, Upper - drug effects | Phosphinic Acids - therapeutic use | Treatment Outcome | Esophageal Sphincter, Upper - physiopathology | Proton Pump Inhibitors - therapeutic use | Pressure | Cross-Over Studies | Propylamines - therapeutic use | Belgium | Propylamines - administration & dosage | Aged | Phosphinic Acids - adverse effects | Propylamines - adverse effects | Gastroesophageal reflux | GABA | Medical colleges | Care and treatment | Index Medicus | Abridged Index Medicus
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10. Full Text Regurgitation Is Less Responsive to Acid Suppression Than Heartburn in Patients With Gastroesophageal Reflux Disease
by Kahrilas, Peter J and Jonsson, Andreas and Denison, Hans and Wernersson, Börje and Hughes, Nesta and Howden, Colin W
Clinical gastroenterology and hepatology, ISSN 1542-3565, 2012, Volume 10, Issue 6, pp. 612 - 619
Gastroenterology and Hepatology | Drug | PPI | Stomach | Pain | Esophagus | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Laryngopharyngeal Reflux - drug therapy | Pyridines - administration & dosage | Esomeprazole - administration & dosage | Humans | Imidazoles - administration & dosage | Treatment Outcome | Heartburn - drug therapy | Gastroesophageal Reflux - drug therapy | Anti-Ulcer Agents - administration & dosage | Randomized Controlled Trials as Topic | Gastroesophageal reflux | Cytogenetics | Care and treatment | Gastrointestinal agents | Index Medicus
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11. Full Text A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (AZD0865) and Esomeprazole for the Treatment of Patients With Nonerosive Reflux Disease
by Dent, John and Kahrilas, Peter J and Hatlebakk, Jan and Vakil, Nimish and Denison, Hans and Franzen, Stefan and Lundborg, Per
The American journal of gastroenterology, ISSN 0002-9270, 01/2008, Volume 103, Issue 1, pp. 20 - 26
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Digestive system | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Other diseases. Semiology | Esophagus | Esomeprazole - administration & dosage | Follow-Up Studies | Gastroesophageal Reflux - diagnosis | Humans | Middle Aged | Imidazoles - administration & dosage | Male | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Heartburn - etiology | Gastric Acidity Determination | Adult | Female | Surveys and Questionnaires | Retrospective Studies | Gastroesophageal Reflux - drug therapy | Severity of Illness Index | Pyridines - administration & dosage | Double-Blind Method | Administration, Oral | Endoscopy, Gastrointestinal | Esophagus - metabolism | Heartburn - diagnosis | Treatment Outcome | Heartburn - drug therapy | Esophagus - pathology | Gastroesophageal Reflux - complications | Adolescent | Aged | Hydrogen-Ion Concentration | Clinical trials | Proton pump inhibitors | Comparative analysis | Antacids | Index Medicus
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