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1. Zahrer Wörterbuch
: Vocabolario Saurano
by Denison, Norman and Grassegger, Hans
2007, GLM, Volume 22, xx, 361
Dialects | Italian | German | German language
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2. Full Text Reducing Adverse Effects During Drug Development: The Example of Lesogaberan and Paresthesia
by Rydholm, Hans, MD, PhD and von Corswant, Christian, PhD and Denison, Hans, MD, PhD and Jensen, Jörgen M., PhD and Lehmann, Anders, PhD and Ruth, Magnus, MD, PhD and Söderlind, Erik, PhD and Aurell-Holmberg, Ann, M Med Sci and Institute of Neuroscience and Physiology and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institute of Clinical Sciences, Section for Anesthesiology, Biomaterials and Orthopaedics, Department of Otorhinolaryngology and Sahlgrenska akademin and Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för öron-, näs- och halssjukdomar and Institutionen för neurovetenskap och fysiologi
Clinical Therapeutics, ISSN 0149-2918, 2016, Volume 38, Issue 4, pp. 946 - 960
Abstract Purpose Lesogaberan, a γ-aminobutyric acid (GABA)B receptor agonist, was developed for the treatment of gastroesophageal reflux disease in patients... 
Internal Medicine | Medical Education | γ-aminobutyric acid (GABA)B receptor agonist | paresthesia | adverse effect | lesogaberan | formulation development | gastroesophageal reflux disease | γ-aminobutyric acid (GABA) | receptor agonist | GABA-A Receptor Agonists - therapeutic use | GABA-A Receptor Agonists - adverse effects | Propylamines - therapeutic use | Humans | Phosphinic Acids - therapeutic use | Phosphinic Acids - adverse effects | Gastroesophageal Reflux - drug therapy | Paresthesia - chemically induced | Propylamines - adverse effects | Gastroesophageal reflux | GABA | Complications and side effects | Medicine, Experimental | Medical research | Development and progression | Hypothesis testing | Formulations | Signs and symptoms | Fractionation | Esophageal sphincter | Medical treatment | Clinical trials | Pharmacology | Paresthesia | Sphincter | Dosage | Drug development | Patients | Esophagus | Literature reviews | Studies | Side effects | γ-Aminobutyric acid | Hypotheses | Pharmaceutical industry | Drug dosages | gamma-aminobutyric acid (GABA)(B) receptor agonist | controlled-trial | gastroesophageal-reflux disease | agonist | Klinisk medicin | volunteers | esophageal sphincter relaxations | adverse-effect | symptoms | Clinical Medicine | inhibitor therapy | Pharmacology & Pharmacy | pump | mechanism
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3. Full Text Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial
by Amarenco, Pierre, Prof and Albers, Gregory W, Prof and Denison, Hans, MD and Easton, J Donald, Prof and Evans, Scott R, Prof and Held, Peter, MD and Hill, Michael D, Prof and Jonasson, Jenny, PhD and Kasner, Scott E, Prof and Ladenvall, Per, MD and Minematsu, Kazuo, Prof and Molina, Carlos A, Prof and Wang, Yongjun, Prof and Wong, K S Lawrence, Prof and Johnston, S Claiborne, Prof and SOCRATES Steering Comm and SOCRATES Steering Committee and Investigators
Lancet Neurology, The, ISSN 1474-4422, 2017, Volume 16, Issue 4, pp. 301 - 310
Summary Background Ticagrelor is an effective antiplatelet therapy for patients with coronary atherosclerotic disease and might be more effective than aspirin... 
Neurology | CRYPTOGENIC STROKE | EARLY RISK | CLOPIDOGREL | STENOSIS | REDUCTION | SUBTYPES | MINOR STROKE | RECURRENCE | CLINICAL NEUROLOGY | ATORVASTATIN | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Humans | Middle Aged | Proportional Hazards Models | Atherosclerosis - complications | Male | Treatment Outcome | International Cooperation | Stroke - drug therapy | Dose-Response Relationship, Drug | Stroke - etiology | Adenosine - analogs & derivatives | Adenosine - therapeutic use | Fibrinolytic Agents - therapeutic use | Ischemic Attack, Transient - etiology | Adult | Female | Aged | Aspirin - therapeutic use | Ticagrelor | Stroke (Disease) | Prevention | Medical colleges | Aspirin | Neurosciences | Ischemia | Analysis | Cardiac patients | Clinical trials | Disease prevention | Stroke | Heart attacks | Diabetes | Thrombosis | Patients | Clinical outcomes
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4. Full Text Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack
by Johnston, S. Claiborne and Amarenco, Pierre and Albers, Gregory W and Denison, Hans and Easton, J. Donald and Evans, Scott R and Held, Peter and Jonasson, Jenny and Minematsu, Kazuo and Molina, Carlos A and Wang, Yongjun and Wong, K.S. Lawrence and SOCRATES Steering Comm Investigato and SOCRATES Steering Committee and Investigators
The New England Journal of Medicine, ISSN 0028-4793, 07/2016, Volume 375, Issue 1, pp. 35 - 43
In this double-blind, randomized trial involving 13,199 patients with ischemic stroke or transient ischemic attack, ticagrelor was not superior to aspirin in... 
MEDICINE, GENERAL & INTERNAL | EARLY RISK | AZD6140 | CLOPIDOGREL | ANTAGONIST | MINOR STROKE | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Stroke - drug therapy | Purinergic P2Y Receptor Antagonists - adverse effects | Aspirin - adverse effects | Adenosine - adverse effects | Adenosine - analogs & derivatives | Adenosine - therapeutic use | Female | Aged | Aspirin - therapeutic use | Hemorrhage - chemically induced | Platelet Aggregation Inhibitors - therapeutic use | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cerebral ischemia | Care and treatment | Aspirin | Dosage and administration | Ticagrelor | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | Intravenous administration | Transient ischemic attack | Risk groups | Preventive medicine | Hemorrhage | Patients | Thrombolysis | Bleeding | Ischemia | Comparative studies | Drug therapy | Life Sciences | Human health and pathology
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5. Full Text Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial
by Shaheen, Nicholas J and Denison, Hans and Björck, Karin and Karlsson, Maria and Silberg, Debra G
Gut, ISSN 0017-5749, 09/2013, Volume 62, Issue 9, pp. 1248 - 1255
Objective Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting... 
ACID | barretts oesophagus | GABA(B) AGONIST BACLOFEN | barretts metaplasia | ESOPHAGEAL SPHINCTER RELAXATIONS | SYMPTOMS | gastro-oesophageal reflux | gastro-oesophageal reflux disease | PATHOPHYSIOLOGY | proton pump inhibitors | GERD | IMPEDANCE | PUMP INHIBITOR THERAPY | GABA(B) receptor agonists | lesogaberan | GASTROENTEROLOGY & HEPATOLOGY | gastrointestinal endoscopy | barretts carcinoma | Double-Blind Method | Esophageal Sphincter, Lower - drug effects | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Treatment Outcome | Dose-Response Relationship, Drug | Esophageal Sphincter, Lower - physiopathology | GABA-A Receptor Agonists - administration & dosage | Propylamines - administration & dosage | Proton Pump Inhibitors - administration & dosage | Adult | Female | Drug Monitoring | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy | Phosphinic Acids - administration & dosage | Gastroesophageal reflux | Protons | Stomach | Acids | Nervous system | Endoscopy | Patients
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6. Full Text A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial
by Boeckxstaens, Guy E and Beaumont, Hanneke and Hatlebakk, Jan G and Silberg, Debra G and Björck, Karin and Karlsson, Maria and Denison, Hans
Gut, ISSN 0017-5749, 09/2011, Volume 60, Issue 9, pp. 1182 - 1188
ObjectiveTo evaluate the efficacy and tolerability of add-on treatment with lesogaberan (AZD3355), a novel reflux inhibitor, in patients with persistent... 
GASTROESOPHAGEAL-REFLUX | AGONIST BACLOFEN | MANAGEMENT | ACID | DISEASE | ESOPHAGEAL SPHINCTER RELAXATIONS | GASTROENTEROLOGY & HEPATOLOGY | Humans | Middle Aged | Gastrointestinal Agents - administration & dosage | Male | Young Adult | GABA-A Receptor Agonists - administration & dosage | Time Factors | Adult | Female | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy | Phosphinic Acids - administration & dosage | GABA-A Receptor Agonists - therapeutic use | Drug Administration Schedule | Phosphinic Acids - therapeutic use | Treatment Outcome | Proton Pump Inhibitors - therapeutic use | Propylamines - therapeutic use | Propylamines - administration & dosage | Epidemiologic Methods | Adolescent | Gastrointestinal Agents - therapeutic use | Aged | Gastrointestinal Agents - adverse effects | Phosphinic Acids - adverse effects | Propylamines - adverse effects | Drugs | Gastroesophageal reflux | Disease | Patients
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7. Full Text A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (AZD0865) and Esomeprazole for the Treatment of Patients With Nonerosive Reflux Disease
by Dent, John and Kahrilas, Peter J and Hatlebakk, Jan and Vakil, Nimish and Denison, Hans and Franzen, Stefan and Lundborg, Per
The American Journal of Gastroenterology, ISSN 0002-9270, 01/2008, Volume 103, Issue 1, pp. 20 - 26
OBJECTIVES: AZD0865 is a gastric acid-suppressing agent that has a rapid onset of action and long duration of effect. This double-blind, randomized,... 
HEARTBURN | EFFICACY | EROSIVE ESOPHAGITIS | OMEPRAZOLE | SYMPTOMS | AZD0865 | GASTROENTEROLOGY & HEPATOLOGY | Esomeprazole - administration & dosage | Follow-Up Studies | Gastroesophageal Reflux - diagnosis | Humans | Middle Aged | Imidazoles - administration & dosage | Male | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Heartburn - etiology | Gastric Acidity Determination | Adult | Female | Surveys and Questionnaires | Retrospective Studies | Gastroesophageal Reflux - drug therapy | Severity of Illness Index | Pyridines - administration & dosage | Double-Blind Method | Administration, Oral | Endoscopy, Gastrointestinal | Esophagus - metabolism | Heartburn - diagnosis | Treatment Outcome | Heartburn - drug therapy | Esophagus - pathology | Gastroesophageal Reflux - complications | Adolescent | Aged | Hydrogen-Ion Concentration | Clinical trials | Proton pump inhibitors | Comparative analysis | Antacids
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8. Full Text Impact of regurgitation on health-related quality of life in gastro-oesophageal reflux disease before and after short-term potent acid suppression therapy
by Kahrilas, Peter J and Jonsson, Andreas and Denison, Hans and Wernersson, Börje and Hughes, Nesta and Howden, Colin W
Gut, ISSN 0017-5749, 05/2014, Volume 63, Issue 5, pp. 720 - 726
Objective Limited data exist on the impact of regurgitation on health-related quality of life (HRQOL) in gastro-oesophageal reflux disease (GORD). We assessed... 
TRIAL | ESOMEPRAZOLE | DIAGNOSIS | PRIMARY-CARE | HEARTBURN | VALIDATION | PUMP INHIBITOR THERAPY | SYMPTOMS | QUESTIONNAIRE | GASTROENTEROLOGY & HEPATOLOGY | Drug Administration Schedule | Follow-Up Studies | Humans | Treatment Outcome | Heartburn - drug therapy | Proton Pump Inhibitors - therapeutic use | Esomeprazole - therapeutic use | Randomized Controlled Trials as Topic | Antacids - therapeutic use | Esophagitis, Peptic - drug therapy | Gastroesophageal Reflux - complications | Heartburn - etiology | Quality of Life | Surveys and Questionnaires | Retrospective Studies | Imidazoles - therapeutic use | Gastroesophageal Reflux - drug therapy | Esophagitis, Peptic - complications | Pyridines - therapeutic use | Esophageal diseases | Care and treatment | Research | Quality of life | Gastroesophageal reflux | Stomach | Side effects | Pneumonia | Acids | Questionnaires | Clinical medicine | Antacids
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9. Full Text Impact of regurgitation on health-related quality of life in gastro-oesophageal re flux disease before and after short-term potent acid suppression therapy
by Kahrilas, Peter J and Jonsson, Andreas and Denison, Hans and Wernersson, Börje and Hughes, Nesta and Howden, Colin W
Gut, ISSN 0017-5749, 05/2014, Volume 63, Issue 5, pp. 720 - 726
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10. Full Text Disability after minor stroke and TIA: A secondary analysis of the SOCRATES trial
by Cucchiara, Brett and George, Donna Kurowski and Kasner, Scott E and Knutsson, Mikael and Denison, Hans and Ladenvall, Per and Amarenco, Pierre and Johnston, S Claiborne
Neurology, ISSN 0028-3878, 08/2019, Volume 93, Issue 7, pp. e708 - e716
OBJECTIVETo examine factors associated with disability following TIA and minor stroke, including poststroke complications such as stroke recurrence, major... 
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11. Full Text Esophageal mucosal breaks in gastroesophageal reflux disease partially responsive to proton pump inhibitor therapy
by Shaheen, Nicholas J and Denison, Hans and Björck, Karin and Silberg, Debra G
American Journal of Gastroenterology, ISSN 0002-9270, 04/2013, Volume 108, Issue 4, pp. 529 - 534
OBJECTIVES: Approximately 20-30% of patients with gastroesophageal reflux disease (GERD) do not experience complete symptom resolution during proton pump... 
VALIDATION | SYMPTOMS | PRIMARY-CARE | ACID | GASTROENTEROLOGY & HEPATOLOGY | Prevalence | Gastroesophageal Reflux - diagnosis | Esophagitis, Peptic - etiology | Humans | Middle Aged | Phosphinic Acids - therapeutic use | Esophagitis, Peptic - diagnosis | Male | Treatment Outcome | Proton Pump Inhibitors - therapeutic use | Esophagitis, Peptic - drug therapy | Gastroesophageal Reflux - complications | Propylamines - therapeutic use | Adult | Female | Endoscopy | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy
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12. Full Text Effects of Lesogaberan on Reflux and Lower Esophageal Sphincter Function in Patients With Gastroesophageal Reflux Disease
by Boeckxstaens, Guy E and Beaumont, Hanneke and Mertens, Veerle and Denison, Hans and Ruth, Magnus and Adler, John and Silberg, Debra G and Sifrim, Daniel
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 2, pp. 409 - 417
Background & Aims Transient lower esophageal sphincter relaxations (TLESRs) are a major mechanism behind reflux. This study assessed the effects of lesogaberan... 
Gastroenterology and Hepatology | Transient Lower Esophageal Sphincter Relaxation | Partial Response | AZD3355 | Reflux Inhibitor | ACID REFLUX | BACLOFEN | HEARTBURN | DETERMINANTS | PROTON PUMP INHIBITORS | SYMPTOMS | GABA(B) RECEPTOR AGONIST | PERCEPTION | PRIMARY-CARE | RELAXATIONS | GASTROENTEROLOGY & HEPATOLOGY | Esophageal pH Monitoring | GABA Agonists - administration & dosage | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | GABA Agonists - adverse effects | Male | GABA Agonists - therapeutic use | Netherlands | Time Factors | Postprandial Period | Adult | Female | Drug Therapy, Combination | Gastroesophageal Reflux - drug therapy | Phosphinic Acids - administration & dosage | Manometry | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Esophageal Sphincter, Upper - drug effects | Phosphinic Acids - therapeutic use | Treatment Outcome | Esophageal Sphincter, Upper - physiopathology | Proton Pump Inhibitors - therapeutic use | Pressure | Cross-Over Studies | Propylamines - therapeutic use | Belgium | Propylamines - administration & dosage | Aged | Phosphinic Acids - adverse effects | Propylamines - adverse effects | Gastroesophageal reflux | GABA | Medical colleges | Care and treatment
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13. Full Text Symptom profile in partial responders to a proton pump inhibitor compared with treatment-naïve patients with gastroesophageal reflux disease: A post hoc analysis of two study populations
by Vakil, Nimish and Niklasson, Anna and Denison, Hans and Rydén, Anna
BMC Gastroenterology, ISSN 1471-230X, 10/2014, Volume 14, Issue 1, p. 177
Background: Partial response to proton pump inhibitor (PPI) therapy poses a healthcare challenge. This study aimed to compare symptom profiles in partial PPI... 
Abdominal pain | Proton pump inhibitors | Gastric | Constipation | Heartburn | Regurgitation | PERSISTENT | CLASSIFICATION | TRIAL | ARBACLOFEN PLACARBIL | THERAPY | OVERLAP | QUALITY-OF-LIFE | QUESTIONNAIRE | GASTROENTEROLOGY & HEPATOLOGY | FUNCTIONAL HEARTBURN | DYSPEPSIA | Constipation - prevention & control | Proton Pump Inhibitors - adverse effects | Abdominal Pain - prevention & control | Abdominal Pain - etiology | Dyspepsia - etiology | Gastroesophageal Reflux - diagnosis | Dyspepsia - prevention & control | Humans | Middle Aged | Diarrhea - prevention & control | Male | Treatment Outcome | Proton Pump Inhibitors - therapeutic use | Constipation - etiology | Gastroesophageal Reflux - complications | Heartburn - etiology | Adult | Diarrhea - etiology | Female | Aged | Gastroesophageal Reflux - drug therapy | Gastroesophageal reflux | Confidence intervals | Body mass index | Pain | Irritable bowel syndrome | Clinical medicine | Drug therapy | Abdomen
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