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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 4045 - 4050
Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells... 
Glaucoma | Axons | Optic nerve | Eyes | Cell death | Neurons | Small interfering RNA | Mice | Physical trauma | Ganglia | Neuroprotection | Drug discovery | MAP3K12 | ELECTROPORATION | INHIBITOR SELECTIVITY | MULTIDISCIPLINARY SCIENCES | AXONAL REGENERATION | INJURY | DEGENERATION | drug discovery | PATHWAY | neuroprotection | IN-VIVO | NEURONS | MOUSE RETINA | GLAUCOMA | Glaucoma - etiology | Up-Regulation | Rats, Wistar | Humans | Cell Survival - genetics | Male | Retinal Ganglion Cells - pathology | Optic Nerve Diseases - pathology | Cell Death - genetics | RNA Interference | Optic Nerve Injuries - pathology | MAP Kinase Kinase Kinases - antagonists & inhibitors | Cell Survival - physiology | Disease Models, Animal | Optic Nerve Injuries - drug therapy | Cell Survival - drug effects | Retinal Ganglion Cells - enzymology | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Down-Regulation | Cells, Cultured | Rats | Glaucoma - drug therapy | Piperazines - pharmacology | Optic Nerve Injuries - enzymology | Animals | Cell Death - physiology | MAP Kinase Kinase Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Optic Nerve Diseases - etiology | Retinal Ganglion Cells - drug effects | Genomics | Physiological aspects | Retina | Genetic aspects | Research | Health aspects | Genetic screening | Methods | Mitogen-activated protein kinases | Signal transduction | Rodents | Kinases | Cells | Apoptosis | Index Medicus | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2013, Volume 110, Issue 36, pp. E3425 - E3434
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0141137 - e0141137
Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in... 
ACE-INHIBITORS | OPEN-ANGLE GLAUCOMA | AORTIC-ANEURYSM | PIGMENT EPITHELIUM | TYPE-2 RECEPTOR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | INTRAOCULAR-PRESSURE | ANGIOTENSIN-CONVERTING ENZYME | BLOOD-PRESSURE | ENDOTHELIAL GROWTH-FACTOR | Retina - drug effects | Sclera - drug effects | Intraocular Pressure - drug effects | Humans | Glaucoma - drug therapy | Retinal Ganglion Cells - pathology | Animals | Sclera - pathology | Glaucoma - pathology | Mice | Optic Disk - drug effects | Losartan - administration & dosage | Neuroprotective Agents - administration & dosage | Retina - pathology | Optic Disk - pathology | Retinal Ganglion Cells - drug effects | Disease Models, Animal | Glaucoma | Physiological aspects | Care and treatment | Research | Ganglion | Angiotensin | Immunohistochemistry | Neuroprotection | Water treatment | Cell culture | Drinking water | Phosphorylation | Reverse transcription | Retina | Angiotensin receptors | Blood | Receptors | Regression models | Tubulin | Rodents | Eye (anatomy) | Blood pressure | Inhibition | Ganglion cells | Vascular endothelial growth factor | Hypertension | Cell survival | Optic nerve | Extracellular signal-regulated kinase | Creep (materials) | Crush tests | Polymerase chain reaction | Thickness | Retinal ganglion cells | Cell death | Axonal transport | Intraocular pressure | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 06/2017, Volume 94, Issue 6, pp. 1142 - 1154.e6
Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To... 
LZK (leucine zipper kinase) | Neuroprotection | RGC (retinal ganglion cell) | RNAi screen | glaucoma | cell death signaling | DLK (dual leucine zipper kinase) | RETINAL GANGLION-CELLS | CAENORHABDITIS-ELEGANS | INHIBITOR SELECTIVITY | PROTEIN-KINASE | GENE-EXPRESSION | INDUCED DEATH | BBC3 PUMA | MOUSE RETINA | C-JUN | NEUROSCIENCES | AXONAL INJURY | Cell Survival - drug effects | Neurites | Immunoprecipitation | MAP Kinase Kinase Kinases - genetics | Neurons | Human Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | MAP Kinase Kinase Kinases - metabolism | Retinal Ganglion Cells - metabolism | Piperazines - pharmacology | Mice, Knockout | Retinal Ganglion Cells - pathology | Optic Nerve Injuries - genetics | Animals | Flow Cytometry | Retina - cytology | Cell Death | Optic Nerve Injuries - pathology | Mice | Protein Kinase Inhibitors - pharmacology | Real-Time Polymerase Chain Reaction | Retinal Ganglion Cells - drug effects | Disease Models, Animal | Medical colleges | Nervous system diseases | Neurosciences | RNA | Genomics | Amino acids | DNA binding proteins | Genetic screening | Cell death | Analysis | Stem cells | Cellular signal transduction | Research institutes | Ophthalmology | Glaucoma | Drug approval | Prevention | Transcription factors | Disease | Retina | Genomes | Leucine | Kinases | Proteins | Signal transduction | Cell activation | Activating transcription factor 2 | Libraries | Ganglion cells | Optic nerve | Neurodegenerative diseases | siRNA | Gene expression | Ribonucleic acid--RNA | Medical screening | Screens | Leucine zipper proteins | Neurological diseases | Retinal ganglion cells | Apoptosis | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 04/2015, Volume 133, Issue 2, pp. 233 - 241
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 36, pp. 14519 - 14519
Journal Article