Journal of Clinical Oncology, ISSN 0732-183X, 11/2010, Volume 28, Issue 33, pp. 4969 - 4975
Purpose The hu14.18-IL2 fusion protein consists of interleukin-2 molecularly linked to a humanized monoclonal antibody that recognizes the GD2...
COLONY-STIMULATING FACTOR | STAGE-IV NEUROBLASTOMA | REFRACTORY NEUROBLASTOMA | ONCOLOGY | BONE-MARROW-TRANSPLANTATION | CELLULAR CYTOTOXICITY | TARGETED INTERLEUKIN-2 THERAPY | PLUS INTERLEUKIN-2 | HIGH-RISK NEUROBLASTOMA | CANCER GROUP | MONOCLONAL-ANTIBODY CH14.18 | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Interleukin-2 - adverse effects | Humans | Receptors, Interleukin-2 - blood | Antibodies, Monoclonal - adverse effects | Interleukin-2 - therapeutic use | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Infant | Antineoplastic Agents - therapeutic use | Neuroblastoma - mortality | Antibodies, Monoclonal - blood | Interleukin-2 - immunology | Neuroblastoma - drug therapy | Adolescent | Lymphocyte Count | Adult | Child | Antibodies, Monoclonal - immunology | Interleukin-2 - blood | Index Medicus | Pedi10 | Original Reports | To6 | To23
COLONY-STIMULATING FACTOR | STAGE-IV NEUROBLASTOMA | REFRACTORY NEUROBLASTOMA | ONCOLOGY | BONE-MARROW-TRANSPLANTATION | CELLULAR CYTOTOXICITY | TARGETED INTERLEUKIN-2 THERAPY | PLUS INTERLEUKIN-2 | HIGH-RISK NEUROBLASTOMA | CANCER GROUP | MONOCLONAL-ANTIBODY CH14.18 | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Interleukin-2 - adverse effects | Humans | Receptors, Interleukin-2 - blood | Antibodies, Monoclonal - adverse effects | Interleukin-2 - therapeutic use | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Infant | Antineoplastic Agents - therapeutic use | Neuroblastoma - mortality | Antibodies, Monoclonal - blood | Interleukin-2 - immunology | Neuroblastoma - drug therapy | Adolescent | Lymphocyte Count | Adult | Child | Antibodies, Monoclonal - immunology | Interleukin-2 - blood | Index Medicus | Pedi10 | Original Reports | To6 | To23
Journal Article
Future oncology (London, England), 05/2017, Volume 13, Issue 12, p. 1043
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 23, pp. 9554 - 9561
Response to immunocytokine (IC) therapy is dependent on natural killer cells in murine neuroblastoma (NBL) models. Furthermore, killer immunoglobulin-like...
POLYMORPHISMS | ONCOLOGY | RITUXIMAB | HLA GENOTYPES | BONE-MARROW | METASTASES | LYMPHOMA | TARGETED INTERLEUKIN-2 THERAPY | ANTI-GD2 ANTIBODY | CANCER | TRANSPLANTATION | Receptors, KIR - genetics | Humans | Neuroblastoma - genetics | Interleukin-2 - therapeutic use | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Genotype | Infant | Treatment Outcome | HLA Antigens - genetics | Polymorphism, Genetic | Young Adult | Receptors, IgG - genetics | Neuroblastoma - drug therapy | Adolescent | Ligands | HLA-C Antigens - genetics | Killer Cells, Natural - metabolism | Child | HLA-B Antigens - genetics
POLYMORPHISMS | ONCOLOGY | RITUXIMAB | HLA GENOTYPES | BONE-MARROW | METASTASES | LYMPHOMA | TARGETED INTERLEUKIN-2 THERAPY | ANTI-GD2 ANTIBODY | CANCER | TRANSPLANTATION | Receptors, KIR - genetics | Humans | Neuroblastoma - genetics | Interleukin-2 - therapeutic use | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Genotype | Infant | Treatment Outcome | HLA Antigens - genetics | Polymorphism, Genetic | Young Adult | Receptors, IgG - genetics | Neuroblastoma - drug therapy | Adolescent | Ligands | HLA-C Antigens - genetics | Killer Cells, Natural - metabolism | Child | HLA-B Antigens - genetics
Journal Article
Journal of Pediatric Hematology/Oncology, ISSN 1077-4114, 2019, p. 1
Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution...
venoocclusive disease | BMT | antithrombin III | sinusoidal obstruction syndrome | stem cell transplantation
venoocclusive disease | BMT | antithrombin III | sinusoidal obstruction syndrome | stem cell transplantation
Journal Article
5.
Full Text
SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery
Blood, ISSN 0006-4971, 10/2018, Volume 132, Issue 17, pp. 1737 - 1749
The Primary Immune Deficiency Treatment Consortium (PIDTC) performed a retrospective analysis of 662 patients with severe combined immunodeficiency (SCID) who...
CRITERIA | SEVERE COMBINED IMMUNODEFICIENCY | BONE-MARROW-TRANSPLANTATION | DISEASE | HCT | EXPERIENCE | COHORT | STEM-CELL TRANSPLANTATION | HEMATOLOGY | RECONSTITUTION | Plenary Paper | 100
CRITERIA | SEVERE COMBINED IMMUNODEFICIENCY | BONE-MARROW-TRANSPLANTATION | DISEASE | HCT | EXPERIENCE | COHORT | STEM-CELL TRANSPLANTATION | HEMATOLOGY | RECONSTITUTION | Plenary Paper | 100
Journal Article
Pediatric Diabetes, ISSN 1399-543X, 12/2017, Volume 18, Issue 8, pp. 832 - 834
The mainstay of treatment for type 1 diabetes (T1D) is exogenous insulin. Here, we report a case in which exogenous insulin requirements were eliminated after...
aplastic anemia | transplant | type 1 diabetes | autoimmune | BONE-MARROW-TRANSPLANTATION | RISK | REDUCED INTENSITY | MELLITUS | CHILDREN | IMPACT | DISEASES | THERAPY | ENDOCRINOLOGY & METABOLISM | PEDIATRICS | Hematopoietic Stem Cell Transplantation | Male | Diabetes Mellitus, Type 1 - therapy | Humans | Transplantation, Homologous | Adolescent | Transplantation | Type 1 diabetes | Hematopoietic stem cells | Stem cells | Transplants & implants | Diabetes mellitus | Aplastic anemia | Case reports | Diabetes | Insulin | Hemopoiesis | Autoimmune
aplastic anemia | transplant | type 1 diabetes | autoimmune | BONE-MARROW-TRANSPLANTATION | RISK | REDUCED INTENSITY | MELLITUS | CHILDREN | IMPACT | DISEASES | THERAPY | ENDOCRINOLOGY & METABOLISM | PEDIATRICS | Hematopoietic Stem Cell Transplantation | Male | Diabetes Mellitus, Type 1 - therapy | Humans | Transplantation, Homologous | Adolescent | Transplantation | Type 1 diabetes | Hematopoietic stem cells | Stem cells | Transplants & implants | Diabetes mellitus | Aplastic anemia | Case reports | Diabetes | Insulin | Hemopoiesis | Autoimmune
Journal Article
Future Oncology, ISSN 1479-6694, 05/2017, Volume 13, Issue 12, pp. 1043 - 1047
Journal Article
Journal of Pediatric Hematology/Oncology, ISSN 1077-4114, 03/2015, Volume 37, Issue 2, pp. 79 - 93
The past decade has seen several anticancer immunotherapeutic strategies transition from "promising preclinical models" to treatments with proven clinical...
natural killer cells | neoplasms | immunotherapy | child | NATURAL-KILLER-CELLS | ACUTE MYELOGENOUS LEUKEMIA | TUMOR-CELLS | ACUTE MYELOID-LEUKEMIA | ONCOLOGY | COMPLEX CLASS-I | REGULATORY T-CELLS | INTERLEUKIN-2 THERAPY | PEDIATRICS | HIGH-RISK NEUROBLASTOMA | EX-VIVO | HEMATOLOGY | C-RECEPTOR POLYMORPHISMS | Neoplasms - therapy | Prognosis | Neoplasms - immunology | Humans | Immunotherapy | Killer Cells, Natural - immunology | Adult | Child
natural killer cells | neoplasms | immunotherapy | child | NATURAL-KILLER-CELLS | ACUTE MYELOGENOUS LEUKEMIA | TUMOR-CELLS | ACUTE MYELOID-LEUKEMIA | ONCOLOGY | COMPLEX CLASS-I | REGULATORY T-CELLS | INTERLEUKIN-2 THERAPY | PEDIATRICS | HIGH-RISK NEUROBLASTOMA | EX-VIVO | HEMATOLOGY | C-RECEPTOR POLYMORPHISMS | Neoplasms - therapy | Prognosis | Neoplasms - immunology | Humans | Immunotherapy | Killer Cells, Natural - immunology | Adult | Child
Journal Article
Future Oncology, ISSN 1479-6694, 2014, Volume 10, Issue 9, pp. 1659 - 1678
Novel immune-based therapies are becoming available as additions to, and in some cases as alternatives to, the traditional treatment modalities such as...
natural killer cells | vaccines | immunotherapy | Toll-like receptors | childhood cancer | chimeric antigen receptors | cytokines | monoclonal antibodies | RECURRENT SOLID TUMORS | PULSED DENDRITIC CELLS | WT1 PEPTIDE VACCINATION | BEVACIZUMAB PLUS IRINOTECAN | CHILDRENS ONCOLOGY GROUP | TUMOR-NECROSIS-FACTOR | ONCOLOGY | PHASE-I TRIAL | CHIMERIC-ANTIGEN-RECEPTOR | ACUTE LYMPHOBLASTIC-LEUKEMIA | STEM-CELL TRANSPLANTATION | Pediatrics | Neoplasms - therapy | Neoplasms - immunology | Cancer Vaccines | Humans | Immunotherapy | Child
natural killer cells | vaccines | immunotherapy | Toll-like receptors | childhood cancer | chimeric antigen receptors | cytokines | monoclonal antibodies | RECURRENT SOLID TUMORS | PULSED DENDRITIC CELLS | WT1 PEPTIDE VACCINATION | BEVACIZUMAB PLUS IRINOTECAN | CHILDRENS ONCOLOGY GROUP | TUMOR-NECROSIS-FACTOR | ONCOLOGY | PHASE-I TRIAL | CHIMERIC-ANTIGEN-RECEPTOR | ACUTE LYMPHOBLASTIC-LEUKEMIA | STEM-CELL TRANSPLANTATION | Pediatrics | Neoplasms - therapy | Neoplasms - immunology | Cancer Vaccines | Humans | Immunotherapy | Child
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2008, Volume 26, Issue 26, pp. 4326 - 4332
Purpose Identify prognostic factors that influence outcome after unrelated donor bone marrow transplantation in children with acute myeloid leukemia (AML)....
CANCER-GROUP | SURVIVAL | MULTICENTER | THERAPY | ONCOLOGY | AML TRIALS | PEDIATRIC-PATIENTS | VERSUS-HOST-DISEASE | BLOOD | Prognosis | Humans | Risk Factors | Proportional Hazards Models | Child, Preschool | Male | Antineoplastic Agents - therapeutic use | Remission Induction | Leukemia, Myeloid, Acute - mortality | Adolescent | Bone Marrow Transplantation | Female | Tissue Donors | Child | Leukemia, Myeloid, Acute - therapy | Pediatric Oncology
CANCER-GROUP | SURVIVAL | MULTICENTER | THERAPY | ONCOLOGY | AML TRIALS | PEDIATRIC-PATIENTS | VERSUS-HOST-DISEASE | BLOOD | Prognosis | Humans | Risk Factors | Proportional Hazards Models | Child, Preschool | Male | Antineoplastic Agents - therapeutic use | Remission Induction | Leukemia, Myeloid, Acute - mortality | Adolescent | Bone Marrow Transplantation | Female | Tissue Donors | Child | Leukemia, Myeloid, Acute - therapy | Pediatric Oncology
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 12/2010, Volume 55, Issue 7, pp. 1300 - 1305
Background The effectiveness of killer immunoglobulin‐like receptor (KIR) incompatible, alloreactive natural killer (NK) cells has been primarily documented in...
NK cells | KIR | osteosarcoma | immunotherapy | Osteosarcoma | Immunotherapy | ALLOREACTIVITY | RECOGNITION | DOWN-REGULATION | INHIBITORY RECEPTORS | TUMORS | TRANSPLANTATION | MOLECULES | MHC CLASS-I | MELANOMA | ONCOLOGY | PEDIATRICS | HEMATOLOGY | EXPRESSION | Cytotoxicity Tests, Immunologic | Humans | Histocompatibility Antigens Class I - immunology | Bone Neoplasms - immunology | Reverse Transcriptase Polymerase Chain Reaction | Bone Neoplasms - metabolism | Histocompatibility Antigens Class I - metabolism | Osteosarcoma - immunology | Flow Cytometry | Receptors, KIR - metabolism | Cell Line, Tumor | Killer Cells, Natural - immunology | Major Histocompatibility Complex - immunology | Histocompatibility | Receptors, KIR - immunology | Osteosarcoma - metabolism | Cytotoxicity, Immunologic | Cell culture | Flow cytometry | Pediatrics | Effector cells | Data processing | Immunoglobulin-like receptors | Malignancy | Osteosarcoma cells | Cell surface | Major histocompatibility complex | Donors | Killer cell immunoglobulin-like receptors | Peripheral blood mononuclear cells | Natural killer cells | Solid tumors | Cancer | Index Medicus
NK cells | KIR | osteosarcoma | immunotherapy | Osteosarcoma | Immunotherapy | ALLOREACTIVITY | RECOGNITION | DOWN-REGULATION | INHIBITORY RECEPTORS | TUMORS | TRANSPLANTATION | MOLECULES | MHC CLASS-I | MELANOMA | ONCOLOGY | PEDIATRICS | HEMATOLOGY | EXPRESSION | Cytotoxicity Tests, Immunologic | Humans | Histocompatibility Antigens Class I - immunology | Bone Neoplasms - immunology | Reverse Transcriptase Polymerase Chain Reaction | Bone Neoplasms - metabolism | Histocompatibility Antigens Class I - metabolism | Osteosarcoma - immunology | Flow Cytometry | Receptors, KIR - metabolism | Cell Line, Tumor | Killer Cells, Natural - immunology | Major Histocompatibility Complex - immunology | Histocompatibility | Receptors, KIR - immunology | Osteosarcoma - metabolism | Cytotoxicity, Immunologic | Cell culture | Flow cytometry | Pediatrics | Effector cells | Data processing | Immunoglobulin-like receptors | Malignancy | Osteosarcoma cells | Cell surface | Major histocompatibility complex | Donors | Killer cell immunoglobulin-like receptors | Peripheral blood mononuclear cells | Natural killer cells | Solid tumors | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 23, pp. 9554 - 9561
Response to immunocytokine (IC) therapy is dependent on natural killer cells in murine neuroblastoma (NBL) models. Furthermore, killer immunoglobulin-like...
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 11/2010, Volume 28, Issue 33, pp. 4969 - 4975
PURPOSE: The hu14.18-IL2 fusion protein consists of interleukin-2 molecularly linked to a humanized monoclonal antibody that recognizes the GD2...
Journal Article
Journal of Pediatric Hematology/Oncology, ISSN 1077-4114, 06/2007, Volume 29, Issue 6, pp. 409 - 411
Hemangiopericytoma is a rare vascular tumor, of which 5% to 10% occur in the pediatric population. Although usually benign in infants, local recurrence,...
Infant | Chemotherapy | Hemangiopericytoma | Constitutional chromosomal abnormality | MANAGEMENT | ONCOLOGY | hemangiopericytoma | constitutional chromosomal abnormality | MALIGNANT HEMANGIOPERICYTOMA | PEDIATRICS | infant | HEMATOLOGY | chemotherapy | CHILDREN | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Diagnostic Errors | Humans | Karyotyping | Chromosome Aberrations | Male | Treatment Outcome | Hemangiopericytoma - drug therapy
Infant | Chemotherapy | Hemangiopericytoma | Constitutional chromosomal abnormality | MANAGEMENT | ONCOLOGY | hemangiopericytoma | constitutional chromosomal abnormality | MALIGNANT HEMANGIOPERICYTOMA | PEDIATRICS | infant | HEMATOLOGY | chemotherapy | CHILDREN | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Diagnostic Errors | Humans | Karyotyping | Chromosome Aberrations | Male | Treatment Outcome | Hemangiopericytoma - drug therapy
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2019, Volume 143, Issue 1, pp. 405 - 407
To the Editor: There has been increased appreciation in recent years that severe combined immunodeficiency (SCID) is not one disease, but rather a collection...
ALLERGY | IMMUNOLOGY | Neonates | Severe combined immunodeficiency | Transplants & implants | Radiation | Disorders | Clinical trials | Transplantation | Infants | Lymphocytes T | Alkylation | Defects | Consortia | T-cell receptor | Genotype & phenotype | Killer cells | Newborn babies | Lymphocytes | Diagnosis | Natural killer cells | Genotypes | Autografts | Phenotypes | Cell survival | Complications | Immune reconstitution | Medical screening | Patients | Hemopoiesis | Screening | Chemotherapy | Lymphocytes B | Mutation
ALLERGY | IMMUNOLOGY | Neonates | Severe combined immunodeficiency | Transplants & implants | Radiation | Disorders | Clinical trials | Transplantation | Infants | Lymphocytes T | Alkylation | Defects | Consortia | T-cell receptor | Genotype & phenotype | Killer cells | Newborn babies | Lymphocytes | Diagnosis | Natural killer cells | Genotypes | Autografts | Phenotypes | Cell survival | Complications | Immune reconstitution | Medical screening | Patients | Hemopoiesis | Screening | Chemotherapy | Lymphocytes B | Mutation
Journal Article
Blood, ISSN 0006-4971, 12/2017, Volume 130, Issue 25, pp. 2718 - 2727
The Primary Immune Deficiency Treatment Consortium (PIDTC) is enrolling children with severe combined immunodeficiency (SCID) to a prospective natural history...
SEVERE COMBINED IMMUNODEFICIENCY | OMENN-SYNDROME | HEMATOLOGY | DEFICIENCY | DISEASE | CHILDREN | Prospective Studies | Humans | Risk Factors | Severe Combined Immunodeficiency - mortality | Child, Preschool | Severe Combined Immunodeficiency - therapy | Genotype | Infant | Male | Neonatal Screening | Infection - etiology | Severe Combined Immunodeficiency - complications | Graft vs Host Disease - drug therapy | Hematopoietic Stem Cell Transplantation - adverse effects | Survival Analysis | Female | Immune Reconstitution - genetics | Hematopoietic Stem Cell Transplantation - methods | Tissue Donors | Graft vs Host Disease - etiology | Infant, Newborn | 100 | Clinical Trials and Observations
SEVERE COMBINED IMMUNODEFICIENCY | OMENN-SYNDROME | HEMATOLOGY | DEFICIENCY | DISEASE | CHILDREN | Prospective Studies | Humans | Risk Factors | Severe Combined Immunodeficiency - mortality | Child, Preschool | Severe Combined Immunodeficiency - therapy | Genotype | Infant | Male | Neonatal Screening | Infection - etiology | Severe Combined Immunodeficiency - complications | Graft vs Host Disease - drug therapy | Hematopoietic Stem Cell Transplantation - adverse effects | Survival Analysis | Female | Immune Reconstitution - genetics | Hematopoietic Stem Cell Transplantation - methods | Tissue Donors | Graft vs Host Disease - etiology | Infant, Newborn | 100 | Clinical Trials and Observations
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 07/2019, Volume 66, Issue 7, pp. e27736 - n/a
Purpose Neuroblastoma is the most common extracranial solid pediatric malignancy, with poor outcomes in high‐risk disease. Standard treatment approaches employ...
neuroblastoma | radiotherapy | lymph nodes | high risk | RESECTION | CHEMOTHERAPY | CHILDREN | LOW-DOSE RADIOTHERAPY | THERAPY | ONCOLOGY | PEDIATRICS | LOCAL-CONTROL | STEM-CELL TRANSPLANTATION | HEMATOLOGY | Stem cells | Radiation | Medical care | Transplantation | Neuroblastoma | Radiotherapy | Quality management | Lymphatic system | Medical treatment | Regional analysis | Health risks | Risk | Malignancy | Radiation therapy | Survival | Patients | Nodes | Lymph nodes | Rank tests | Surgery | Irradiation | Lymph
neuroblastoma | radiotherapy | lymph nodes | high risk | RESECTION | CHEMOTHERAPY | CHILDREN | LOW-DOSE RADIOTHERAPY | THERAPY | ONCOLOGY | PEDIATRICS | LOCAL-CONTROL | STEM-CELL TRANSPLANTATION | HEMATOLOGY | Stem cells | Radiation | Medical care | Transplantation | Neuroblastoma | Radiotherapy | Quality management | Lymphatic system | Medical treatment | Regional analysis | Health risks | Risk | Malignancy | Radiation therapy | Survival | Patients | Nodes | Lymph nodes | Rank tests | Surgery | Irradiation | Lymph
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 10/2019, Volume 39, Issue 7, pp. 653 - 667
Inflammatory bowel disease (IBD) affects approximately 1/3 of patients with chronic granulomatous disease (CGD). Comprehensive investigation of the effect of...
Medical Microbiology | allogeneic bone marrow transplantation | Biomedicine | Immunology | Allogeneic hematopoietic cell transplantation | chronic granulomatous disease | primary immunodeficiency | Infectious Diseases | Internal Medicine | inflammatory bowel disease | allogeneic hematopoietic stem cell transplantation | X-LINKED CARRIERS | ANAKINRA | IMMUNOLOGY | FEATURES | COMPLICATIONS | EXPERIENCE | STEM-CELL TRANSPLANTATION | BLOCKADE | Inflammatory bowel disease | Graft-versus-host reaction | Inflammatory bowel diseases | Chronic granulomatous disease | Transplants & implants | Intestine | Transplantation | Hemopoiesis
Medical Microbiology | allogeneic bone marrow transplantation | Biomedicine | Immunology | Allogeneic hematopoietic cell transplantation | chronic granulomatous disease | primary immunodeficiency | Infectious Diseases | Internal Medicine | inflammatory bowel disease | allogeneic hematopoietic stem cell transplantation | X-LINKED CARRIERS | ANAKINRA | IMMUNOLOGY | FEATURES | COMPLICATIONS | EXPERIENCE | STEM-CELL TRANSPLANTATION | BLOCKADE | Inflammatory bowel disease | Graft-versus-host reaction | Inflammatory bowel diseases | Chronic granulomatous disease | Transplants & implants | Intestine | Transplantation | Hemopoiesis
Journal Article