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Journal Article
Stem Cell Research, ISSN 1873-5061, 08/2019, Volume 39, p. 101515
Werner syndrome (WS) is a rare human autosomal recessive disorder characterized by early onset of aging-associated diseases, chromosomal instability, and... 
Telomeres | Complications and side effects | Care and treatment | Aging | Karyotypes | Research | Werner syndrome
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2008, Volume 180, Issue 5, pp. 897 - 904
Human embryonic stem cells (hESCs) are potential therapeutic tools and models of human development. With a growing interest in primary cilia in signal... 
Microscopy | Neurons | Report | Cell nucleus | Stem cells | Cell lines | Antibodies | Cultured cells | Embryonic stem cells | Cellular differentiation | Cilia | ACTIVATOR | GLI TRANSCRIPTION FACTORS | NODAL FLOW | DISEASE | MOUSE | MOTOR | RELEASE | INTRAFLAGELLAR TRANSPORT | REPRESSOR FUNCTIONS | EXPRESSION | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Axoneme - metabolism | Humans | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Male | Embryonic Stem Cells - ultrastructure | Axoneme - genetics | Cell Differentiation - genetics | Hedgehog Proteins - genetics | Axoneme - ultrastructure | Kruppel-Like Transcription Factors - metabolism | Cilia - ultrastructure | Female | Patched Receptors | Culture Media, Serum-Free - pharmacology | Nuclear Proteins - genetics | Cell Lineage - genetics | Cell Line | Microscopy, Electron, Transmission | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Cilia - metabolism | Cilia - genetics | Transcription Factors - metabolism | Microscopy, Confocal | Fluorescent Antibody Technique | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Evaluation | Motility | Cilia and ciliary motion | Research | Properties | Human growth | Electron microscopy | Methods | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 51, p. E10972
Progeroid syndromes are rare genetic disorders that phenotypically resemble natural aging. Different causal mutations have been identified, but no molecular... 
Senescence | Identification methods | Gene regulation | Disorders | Rothmund-Thomson syndrome | Progeroid syndromes | Alterations | Progeria | Aging | Bioindicators | Deoxyribonucleic acid--DNA | Therapeutic applications | Abnormalities | Gene expression | Patients | Cells | DNA biosynthesis | Stem cells | Epigenetics | Biomarkers | Replication | Aging (natural) | Mutation | Pluripotency | Tumors
Journal Article
Current Gene Therapy, ISSN 1566-5232, 2013, Volume 13, Issue 2, pp. 93 - 98
Journal Article
Cell Cycle, ISSN 1538-4101, 07/2018, Volume 17, Issue 13, pp. 1667 - 1681
Organismal aging entails a gradual decline of normal physiological functions and a major contributor to this decline is withdrawal of the cell cycle, known as... 
replication stress | aging | replication timing | Cellular senescence | GLOBAL REORGANIZATION | TUMOR SUPPRESSION | HUMAN-CELLS | ONCOGENE-INDUCED SENESCENCE | NUCLEAR LANDSCAPE | CELL BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | GILFORD-PROGERIA-SYNDROME | DERMAL FIBROBLASTS | GROWTH-FACTOR | GENOME ORGANIZATION
Journal Article
Blood Cells, Molecules and Diseases, ISSN 1079-9796, 03/2007, Volume 38, Issue 2, pp. 135 - 136
Journal Article
Current Gene Therapy, ISSN 1566-5232, 04/2013, Volume 13, Issue 2, pp. 93 - 98
Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research... 
Journal Article
Current gene therapy, 04/2013, Volume 13, Issue 2, p. 93
Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research... 
DNA - genetics | Genomic Instability | Animals | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Humans | Cell Differentiation | Induced Pluripotent Stem Cells - immunology | Mice | Cell Culture Techniques | Embryonic Stem Cells - immunology | Induced Pluripotent Stem Cells - cytology
Journal Article
Current Protocols in Cell Biology, ISSN 1934-2500, 2014, Volume 2014, pp. 22.18.1 - 22.18.13
Understanding the regulatory principles ensuring complete DNA replication in each cell division is critical for deciphering the mechanisms that maintain... 
Origins | DNA replication | Replication timing | Bioinformatics | Next-generation sequencing (NGS) | Chromosomes - metabolism | Eukaryotic Cells - metabolism | DNA Replication - physiology | Chromosomes - genetics | Chromosome Mapping - methods | Replication Origin - physiology
Journal Article
Current Protocols in Cell Biology, ISSN 1934-2500, 2014, Volume 2014, pp. 22.20.1 - 22.20.17
Recent advances in genome-sequencing technology have led to the complete mapping of DNA replication initiation sites in the human genome. This thorough origin... 
DNA replication | Replication origins | Next-generation sequencing (NGS) | DNA Replication | Animals | Replication Origin | Chromosome Mapping - methods | Chromosomes, Human - genetics | Humans
Journal Article
Genome Research, ISSN 1088-9051, 01/2011, Volume 21, Issue 9, pp. 1438 - 1449
In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive.... 
Journal Article
Genome Research, ISSN 1088-9051, 07/2011, Volume 21, Issue 9, pp. 1438 - 1449
In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive.... 
Life Sciences | Cellular Biology | Quantitative Methods | Bioinformatics | Computer Science
Journal Article
01/2009, ISBN 1109125348
The development of lentiviral vectors greatly improved the prospects of gene therapy. Several groups have used such vectors to cure hemoglobinopathies in mouse... 
Cellular biology
Dissertation
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