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European Biophysics Journal, ISSN 0175-7571, 07/2019, Volume 48, Issue S1, pp. 1 - 264
Journal Article
Journal Article
PLoS Medicine, ISSN 1549-1277, 06/2007, Volume 4, Issue 6, pp. 1071 - 1086
Background Schistosomiasis-infection with helminth parasites in the genus Schistosoma, including S. mansoni-is a widespread, devastating tropical disease... 
MEDICINE, GENERAL & INTERNAL | INHIBITION | TRYPANOTHIONE REDUCTASE | MITOCHONDRIAL | PLASMODIUM-FALCIPARUM | ESCHERICHIA-COLI | OLTIPRAZ | SELENOCYSTEINE | MAMMALIAN SELENOPROTEIN | MAJOR METABOLITE | MANNICH-BASES | Schistosomicides - pharmacology | Multienzyme Complexes - metabolism | Male | Schistosomicides - therapeutic use | RNA Interference | Schistosomiasis mansoni - prevention & control | Drug Design | Female | Auranofin - therapeutic use | Schistosoma mansoni - growth & development | NADH, NADPH Oxidoreductases - metabolism | Auranofin - pharmacology | Recombinant Proteins - metabolism | Schistosoma mansoni - drug effects | NADH, NADPH Oxidoreductases - genetics | Recombinant Proteins - antagonists & inhibitors | Oxidation-Reduction | Schistosoma mansoni - enzymology | Mice, Inbred C57BL | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Multienzyme Complexes - genetics | Multienzyme Complexes - antagonists & inhibitors | Animals | Schistosomiasis mansoni - parasitology | Signal Transduction - drug effects | Mice | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Kinetics | Schistosomiasis | Enzymes | Reducing agents (Chemistry) | Drug targeting | Genetic aspects | Drug therapy | Health aspects | Methods | Infectious Diseases | Biochemistry | Drugs and adverse drug reactions | Microbiology | Medicine in Developing Countries
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 10/2012, Volume 2012, Issue 29, pp. 5774 - 5788
In our ongoing research program into the discovery of new anticancer drugs , we were interested in the preparation of naphthoquinone scaffolds bearing... 
Quinones | Amino acids | Medicinal chemistry | Antitumor agents | Radical reactions | Alkylation | ANTIBIOTICS | ENANTIOSELECTIVE SYNTHESIS | ANALOG | CHEMISTRY, ORGANIC | BETA-DICARBONYL COMPOUNDS | DERIVATIVES | Free radicals (Chemistry)
Journal Article
The FEBS journal, ISSN 1742-464X, 11/2019
The chemokine CCR5 receptor is target of maraviroc, a negative allosteric modulator of CCR5 that blocks the HIV protein gp120 from associating with the... 
Life Sciences | Biochemistry, Molecular Biology | Biophysics
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 05/2017, Volume 139, Issue 17, pp. 6128 - 6137
Artificial synthetic molecules able to adopt well-defined stable secondary structures comparable to those found in nature (“foldamers”) have considerable... 
CORE | DESIGN | HIGH-THROUGHPUT | SEQUENCE | HIGH-RESOLUTION STRUCTURE | OLIGOUREAS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | HYDRATION | TOOL | Water | Usage | Crystals | Molecular dynamics | Nuclear magnetic resonance spectroscopy | Chemical properties | Research | Structure
Journal Article
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 11/2017, Volume 28, Issue 11, pp. 2887 - 2894
The fast, efficient, and functional group tolerant last-step radiolabeling of bioconjugates is crucial for positron emission tomography (PET) applications. In... 
RADIOPHARMACEUTICALS | PALLADIUM-CATALYZED CARBONYLATION | MONOXIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SILACARBOXYLIC ACIDS | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | PET TRACERS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | ESTROGEN-RECEPTOR
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2014, Volume 24, Issue 11, pp. 2512 - 2516
Journal Article
Synlett, ISSN 0936-5214, 07/2012, Volume 23, Issue 11, pp. 1621 - 1624
Abstract We discovered that anilines were suitable for the direct C–H arylation of benzoquinone in the presence of tert -butyl nitrite. This new reaction... 
letter | aniline | radical | aryl diazonium salt | direct C-H arylation | quinone | CHEMISTRY, ORGANIC | KINAMYCINS | DECARBOXYLATION | AROMATIC-COMPOUNDS | ARYLBORONIC ACIDS | DISCOVERY | CHEMISTRY | ARYL-SUBSTITUTED 1,4-BENZOQUINONE | HETEROAROMATIC BASES | RADICAL REACTIONS
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 05/2010, Volume 47, Issue 3, pp. 719 - 723
The synthesis of a series of bis‐8‐hydroxyquinoline‐ and bis‐8‐hydroxyquinaldine‐substituted N‐benzyl or thiophenyl amines and their corresponding... 
CHEMISTRY, ORGANIC | CELLS | GLIOBLASTOMA | MECHANISM | STRATEGY
Journal Article
Translational Oncology, ISSN 1936-5233, 2011, Volume 4, Issue 3, pp. 126 - IN7
Abstract Gliomas account for 5% to 7% of all solid cancers in adults and up to 30% of solid cancers in children; glioblastomas are the most malignant type of... 
Oncology | MIGRATION | APOPTOSIS | ONCOLOGY | SODIUM-PUMP | IN-VIVO | RESISTANCE | SENSITIVITY | TEMOZOLOMIDE INCREASES | MECHANISMS | GLIOBLASTOMA CELLS | SPECIAL EMPHASIS
Journal Article
Journal of Organometallic Chemistry, ISSN 0022-328X, 2004, Volume 689, Issue 25, pp. 4678 - 4682
Starting from triazacyclononane, easily accessible ferrocenic quinoline derivatives were synthesized. Their antiplasmodial properties were investigated against... 
Plasmodium falciparum | Bioorganometallics | Malaria | Ferroquine | Triazacyclononane | TACN 1,4,7-triazacyclononane | TEA, triethylamine | ANTIPLASMODIAL ACTIVITY | BISQUINOLINES | ferroquine | PERMEABILITY | AMINO | bioorganometallics | CHEMISTRY, ORGANIC | CHLOROQUINE ANALOGS | malaria | MALARIA PARASITES | SOLUBILITY |