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1. Full Text Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study
by Feagan, Brian G, Prof and Sandborn, William J, MD and D'Haens, Geert, Prof and Panés, Julián, Prof and Kaser, Arthur, Prof and Ferrante, Marc, Prof and Louis, Edouard, Prof and Franchimont, Denis, Prof and Dewit, Olivier, Prof and Seidler, Ursula, Prof and Kim, Kyung-Jo, Prof and Neurath, Markus F, Prof and Schreiber, Stefan, Prof and Scholl, Paul, MB BChir and Pamulapati, Chandrasena, PhD and Lalovic, Bojan, PhD and Visvanathan, Sudha, PhD and Padula, Steven J, MD and Herichova, Ivona, PhD and Soaita, Adina, PhD and Hall, David B, PhD and Böcher, Wulf O, Prof
Lancet, The, ISSN 0140-6736, 2017, Volume 389, Issue 10080, pp. 1699 - 1709
Summary Background The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Crohn's disease. We aimed to assess the... 
Internal Medicine | TRIAL | CELLS | MEDICINE, GENERAL & INTERNAL | ANTI-TNF | INFLAMMATORY-BOWEL-DISEASE | EFFICACY | ULCERATIVE-COLITIS | NECROSIS-FACTOR ANTAGONISTS | ANTITUMOR | MAINTENANCE THERAPY | FACTOR-ALPHA | Clinical trials | Monoclonal antibodies | Medicine, Experimental | Medical research | Interleukins | Intravenous administration | Pathogenesis | Mucosa | Interleukin | Interleukin 23 | Antagonists | Intravenous therapy | Randomization | Endoscopes | Motivation | Gastroenterology | Remission | Tumor necrosis factor-TNF | Colon | Safety | Active control | Chronic illnesses | Psoriasis | Cytokines | Ileitis | Nausea | Inflammation | Crohn's disease | Disease control | Patients | Ileum | Crohns disease | Inflammatory bowel disease | Interactive systems | Tumor necrosis factor | Ulcers | TNF inhibitors | Tumors | Index Medicus | Abridged Index Medicus
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2. Full Text Seven temperate terrestrial planets around the nearby ultracool dwarf star TRAPPIST-1
by Gillon, Michaël and Triaud, Amaury H. M. J and Demory, Brice-Olivier and Jehin, Emmanuël and Agol, Eric and Deck, Katherine M and Lederer, Susan M and De Wit, Julien and Burdanov, Artem and Ingalls, James G and Bolmont, Emeline and Leconte, Jeremy and Raymond, Sean N and Selsis, Franck and Turbet, Martin and Barkaoui, Khalid and Burgasser, Adam and Burleigh, Matthew R and Carey, Sean J and Chaushev, Aleksander and Copperwheat, Chris M and Delrez, Laetitia and Fernandes, Catarina S and Holdsworth, Daniel L and Kotze, Enrico J and Van Grootel, Valérie and Almleaky, Yaseen and Benkhaldoun, Zouhair and Magain, Pierre and Queloz, Didier
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 456 - 460
One aim of modern astronomy is to detect temperate, Earth-like exoplanets that are well suited for atmospheric characterization. Recently, three Earth-sized... 
HABITABLE ZONES | MODELS | SUPER-EARTHS | MULTIDISCIPLINARY SCIENCES | MAIN-SEQUENCE STARS | TRANSITING PLANETS | ECCENTRICITY | SYSTEMS | STELLAR | INVERSION | RESONANCES | Exobiology | Temperature | Planets | Water - analysis | Water - chemistry | Stars, Celestial | Extraterrestrial Environment - chemistry | Terrestrial planets | Discovery and exploration | Extrasolar planets | Earth | Space telescopes | Solar systems | Stars & galaxies | Light | Index Medicus | Physics - Earth and Planetary Astrophysics | Earth and Planetary Astrophysics | Sciences of the Universe | Astrophysics
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3. Full Text Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial
by Laharie, David, Prof and Bourreille, Arnaud, MD and Branche, Julien, MD and Allez, Matthieu, Prof and Bouhnik, Yoram, Prof and Filippi, Jerome, MD and Zerbib, Frank, Prof and Savoye, Guillaume, Prof and Nachury, Maria, MD and Moreau, Jacques, MD and Delchier, Jean-Charles, Prof and Cosnes, Jacques, Prof and Ricart, Elena, MD and Dewit, Olivier, Prof and Lopez-Sanroman, Antonio, MD and Dupas, Jean-Louis, Prof and Carbonnel, Franck, Prof and Bommelaer, Gilles, Prof and Coffin, Benoit, Prof and Roblin, Xavier, MD and Van Assche, Gert, Prof and Esteve, Maria, MD and Färkkilä, Martti, Prof and Gisbert, Javier P, MD and Marteau, Philippe, Prof and Nahon, Stephane, MD and de Vos, Martine, Prof and Franchimont, Denis, Prof and Mary, Jean-Yves, PhD and Colombel, Jean-Frederic, Prof and Lémann, Marc, Prof and Grp Etud Therapeutiques des Affect and Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9857, pp. 1909 - 1915
Summary Background Ciclosporin and infliximab are potential rescue treatments to avoid colectomy in patients with acute severe ulcerative colitis refractory to... 
Internal Medicine | COLECTOMY | MEDICINE, GENERAL & INTERNAL | MULTICENTER | THERAPY | EFFICACY | AZATHIOPRINE | CONSENSUS | EXPERIENCE | OUTCOMES | 5-AMINOSALICYLIC ACID | Steroids - administration & dosage | Acute Disease | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Cyclosporine - therapeutic use | Infliximab | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Treatment Failure | Adult | Female | Colitis, Ulcerative - drug therapy | Infusions, Intravenous | Drug Resistance | Complications and side effects | Dosage and administration | Cyclosporine | Research | Drug therapy | Ulcerative colitis | Inflammatory bowel disease | Substance abuse treatment | Heart attacks | Human immunodeficiency virus--HIV | Pharmaceutical industry | Drug resistance | Drug dosages | Steroids | Index Medicus | Abridged Index Medicus | Drugs | International organizations | Side effects | Mortality | Clinical trials | corticoids | Organic chemistry | Chemical Sciences
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4. Full Text Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
by Fisher, Sheila A and Regueiro, Miguel D and Anderson, Carl A and Prescott, Natalie J and Mathew, Christopher G and Rutgeerts, Paul and Parkes, Miles and Steinhart, A Hillary and Drummond, Hazel and Bitton, Alain and Georges, Michel and Gut, Ivo and Jewell, Derek and Barrett, Jeffrey C and Daly, Mark J and Dewit, Olivier and Bumpstead, Suzannah and Hansoul, Sarah and Hugot, Jean-Pierre and Barmada, M Michael and Xavier, Ramnik J and Libioulle, Cécile and Tremelling, Mark and Laukens, Debby and Datta, Lisa Wu and Kistner, Emily O and Onnie, Clive M and Griffiths, Anne M and Franchimont, Denis and Lathrop, Mark and Nimmo, Elaine and Green, Todd and Mansfield, John and Zelenika, Diana and Deloukas, Panos and Taylor, Kent D and Ahmad, Tariq and de Vos, Martine and Van Gossum, André and Duerr, Richard H and Silverberg, Mark S and Nicolae, Dan L and Rotter, Jerome I and Schumm, L Philip and Cardon, Lon R and Ghori, Jilur and Heath, Simon and Dassopoulos, Themistocles and Vermeire, Severine and Sandor, Cynthia and Satsangi, Jack and Marchini, Jonathan and Gwilliam, Rhian and Louis, Edouard and Rioux, John D and Mni, Myriam and Belaiche, Jacques and Targan, Stephan R and Brant, Steven R and Murtha, Michael T and Cho, Judy H and Wellcome Trust Case Control and NIDDK IBD Genetics Consortium and Belgian-French IBD Consortium and Wellcome Trust Case Control Consortium and the NIDDK IBD Genetics Consortium and the Belgian-French IBD Consortium and the Wellcome Trust Case Control Consortium
Nature Genetics, ISSN 1061-4036, 08/2008, Volume 40, Issue 8, pp. 955 - 962
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data... 
GENETIC-VARIATION | CELLS | VARIANTS | COLITIS | GENETICS & HEREDITY | RISK | LARGE-SCALE | NONSYNONYMOUS SNPS | IL-23 | EXPRESSION | MULTIPLE | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome, Human | Quantitative Trait Loci | Humans | Physiological aspects | Crohn's disease | Genetic aspects | Research | Genetic susceptibility | Risk factors | Inflammatory bowel disease | Studies | Medical research | Genetics | Genomics | Crohns disease | Index Medicus
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5. Full Text Mesalamine Foam Enema Versus Mesalamine Liquid Enema in Active Left-Sided Ulcerative Colitis
by Cortot, Antoine and Maetz, Denis and Degoutte, Eric and Delette, Olivier and Meunier, Pierre and Tan, Gie and Cazals, Jean-Brice and Dewit, Olivier and Hebuterne, Xavier and Beorchia, Sylvain and Grunberg, Bernard and Leprince, Eric and D'Haens, Geert and Forestier, Sylvie and Idier, Isabelle and Lemann, Marc
The American Journal of Gastroenterology, ISSN 0002-9270, 12/2008, Volume 103, Issue 12, pp. 3106 - 3114
AIM: To determine in a noninferiority study whether mesalamine foam is as effective as mesalamine liquid enema for inducing clinical remission in patients with... 
5-ASA COLONIC FOAM | CONTROLLED TRIAL | METAANALYSIS | EFFICACY | PROCTITIS | SAFETY | MESALAZINE 5-AMINOSALICYLIC ACID | PROCTOSIGMOIDITIS | GASTROENTEROLOGY & HEPATOLOGY | RANDOMIZED TRIAL | REMISSION | Single-Blind Method | Colitis, Ulcerative - complications | Humans | Middle Aged | Proctitis - drug therapy | Proctocolitis - drug therapy | Administration, Rectal | Male | Treatment Outcome | Young Adult | Proctitis - etiology | Enema - methods | Adolescent | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Aged, 80 and over | Proctocolitis - etiology | Adult | Female | Aged | Colitis, Ulcerative - drug therapy | Dosage Forms | Mesalamine - administration & dosage | Mesalamine | Antifungal agents | Ulcerative colitis | Index Medicus
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6. Full Text Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn's disease following treatment with certolizumab pegol
by Hébuterne, Xavier and Lémann, Marc and Bouhnik, Yoram and Dewit, Olivier and Dupas, Jean-Louis and Mross, Michael and D'Haens, Geert and Mitchev, Krassimir and Ernault, Étienne and Vermeire, Séverine and Brixi-Benmansour, Hedia and Moreels, Tom G and Mary, Jean-Yves and Marteau, Philippe and Colombel, Jean-Frédéric
Gut, ISSN 0017-5749, 2013, Volume 62, Issue 2, pp. 201 - 208
To evaluate the efficacy of certolizumab pegol (CZP) in improving endoscopic lesions in patients with active ileocolonic Crohn's disease (CD). This phase IIIB... 
TRIAL | INFLAMMATORY-BOWEL-DISEASE | PROSPECTIVE MULTICENTER | TREATMENT STRATEGIES | EPISODIC TREATMENT | INFLIXIMAB | GASTROENTEROLOGY & HEPATOLOGY | MAINTENANCE THERAPY | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Certolizumab Pegol | Follow-Up Studies | Humans | Immunoglobulin Fab Fragments - adverse effects | Endoscopy, Gastrointestinal | Polyethylene Glycols - adverse effects | Male | Treatment Outcome | Immunoglobulin Fab Fragments - therapeutic use | Polyethylene Glycols - therapeutic use | Remission Induction | Intestinal Mucosa - drug effects | Young Adult | Crohn Disease - drug therapy | Injections, Subcutaneous | Crohn Disease - diagnosis | Adult | Female | Intestinal Mucosa - pathology | Physiological aspects | Care and treatment | Crohn's disease | Research | Patient outcomes | Intestinal mucosa | Bowel disease | Ulcers | Gangrene | Tumor necrosis factor-TNF | Family medical history | Endoscopy | Crohns disease | Index Medicus | Abridged Index Medicus | Certolizumab pegol | anti-TNF agent | endoscopic response | Inflammatory Bowel Disease | 1506 | mucosal healing
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7. Full Text Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
by Libioulle, Cécile and Louis, Edouard and Hansoul, Sarah and Sandor, Cynthia and Farnir, Frédéric and Franchimont, Denis and Vermeire, Séverine and Dewit, Olivier and De Vos, Martine and Dixon, Anna and Demarche, Bruno and Gut, Ivo and Heath, Simon and Foglio, Mario and Liang, Liming and Laukens, Debby and Mni, Myriam and Zelenika, Diana and Van Gossum, André and Rutgeerts, Paul and Belaiche, Jacques and Lathrop, Mark and Georges, Michel
PLoS Genetics, ISSN 1553-7390, 04/2007, Volume 3, Issue 4, pp. 0538 - 0543
To identify novel susceptibility loci for Crohn disease ( CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547... 
ELEMENTS | INFLAMMATORY-BOWEL-DISEASE | NORMALIZATION | VARIANTS | SUSCEPTIBILITY | GENETICS & HEREDITY | Haplotypes | Crohn Disease - genetics | Genetic Predisposition to Disease | Gene Frequency | Humans | Gene Expression Regulation | Molecular Sequence Data | Chromosome Mapping | Receptors, Prostaglandin E - genetics | Sequence Homology, Nucleic Acid | Case-Control Studies | Chromosomes, Human, Pair 5 | Linkage Disequilibrium | Receptors, Prostaglandin E, EP4 Subtype | Base Sequence | Polymorphism, Single Nucleotide | Cohort Studies | Quantitative trait loci | Genetic susceptibility | Crohn's disease | Genetic aspects | Research | Gene expression | Identification and classification | Index Medicus | Genetics and Genomics | Homo (Human) | Inflammatory bowel disease | Genotype & phenotype | Genomics | Colleges & universities | Genetics | Genomes | Chromosomes | Data bases
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8. Full Text Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
by Lathrop, Mark and O'Morain, Colm and Tysk, Curt and Zelenika, Diana and Hugot, Jean-Pierre and Del-Favero, Jurgen and Vermeire, Severine and Colombel, Jean-Frédéric and Nakamura, Kayo and Dewit, Olivier and Finkel, Yigael and Franchimont, Denis and Laukens, Debby and Lémann, Marc and Mni, Myriam and Momozawa, Yukihide and Louis, Edouard and Goossens, Dirk and Libioulle, Cécile and Cleynen, Isabelle and Reenaers, Catherine and Coppieters, Wouter and Gassull, Miquel A and Amininejad, Leila and Almer, Sven and de Vos, Martine and de Rijk, Peter and Georges, Michel and Rutgeerts, Paul and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Gastroenterologi och hepatologi and Hjärt- och Medicincentrum and Östergötlands Läns Landsting and Hälsouniversitetet and Endokrin- och magtarmmedicinska kliniken US
Nature Genetics, ISSN 1061-4036, 01/2011, Volume 43, Issue 1, pp. 43 - 47
Genome-wide association studies (GWAS) have identified dozens of risk loci for many complex disorders, including Crohn's disease. However, common... 
CONTRIBUTE | RARE VARIANTS | CROHNS-DISEASE | SUSCEPTIBILITY | GENES | GENETICS & HEREDITY | SNPS | COMMON | COMPLEX DISEASES | HERITABILITY | GENOME-WIDE ASSOCIATION | Genetic Variation | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Phenotype | Humans | Inflammatory Bowel Diseases - genetics | Nod2 Signaling Adaptor Protein - genetics | Polymorphism, Single Nucleotide | Receptors, Interleukin - genetics | Sequence Analysis, DNA | Case-Control Studies | Prevention | Inflammatory bowel diseases | Genes | Physiological aspects | Genetic aspects | Research | Single nucleotide polymorphisms | Studies | Confidence intervals | Inflammatory bowel disease | Candidates | Genomics | Genetics | Standard deviation | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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9. Full Text Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study
by Leufkens, Anke M., MD and DeMarco, Daniel C., MD and Rastogi, Amit, MD and Akerman, Paul A., MD and Azzouzi, Kassem, MD and Rothstein, Richard I., MD and Vleggaar, Frank P., MD, PhD and Repici, Alessandro, MD and Rando, Giacomo, MD and Okolo, Patrick I., MD, MPH and Dewit, Olivier, MD and Ignjatovic, Ana, MD and Odstrcil, Elizabeth, MD and East, James, MD and Deprez, Pierre H., MD, PhD and Saunders, Brian P., MD, MB and Kalloo, Anthony N., MD and Creel, Bradley, MD and Singh, Vikas, MD and Lennon, Anne Marie, MD, PhD and Siersema, Peter D., MD, PhD and Third Eye Retroscope Randomized Cl and Third Eye Retroscope Randomized Clinical Evaluation [TERRACE] Study Group
Gastrointestinal Endoscopy, ISSN 0016-5107, 2011, Volume 73, Issue 3, pp. 480 - 489
Background Although colonoscopy is currently the optimal method for detecting colorectal polyps, some are missed. The Third Eye Retroscope provides an... 
Gastroenterology and Hepatology | intent to treat | standard colonoscopy | TER | adenoma detection rate | polyp detection rate | Third Eye colonoscopy | TEC | Third Eye Retroscope | ITT | ADR | PDR | AMERICAN-CANCER-SOCIETY | WIDE-ANGLE | SOCIETY-TASK-FORCE | MISS RATES | TO-BACK COLONOSCOPIES | SCREENING COLONOSCOPY | COLORECTAL-CANCER | HIGH-DEFINITION | POLYP DETECTION | RANDOMIZED CONTROLLED-TRIAL | GASTROENTEROLOGY & HEPATOLOGY | Adenoma - diagnosis | Prospective Studies | Colonoscopy - instrumentation | Colonoscopes | Humans | Middle Aged | Male | Colorectal Neoplasms - diagnosis | Young Adult | Adenocarcinoma - diagnosis | Colonic Polyps - diagnosis | Intention to Treat Analysis | Aged, 80 and over | Adult | Female | Aged | Colonoscopy | Adenoma | Index Medicus
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10. Full Text When a black olive kernel causes SBO: First comparison of CT acquisition
by Yildiz, Halil and Dewit, Olivier and Danse, Etienne
BMJ Case Reports, ISSN 1757-790X, 2017, Volume 2017, p. bcr-2017-220795
CT of the abdomen revealed imaging signs indicating mechanical small bowel obstruction (SBO) related to ileal wall thickening ( figure 1A ) and to the presence... 
radiology | Crohn's disease | Inflammatory bowel disease | Family medical history | Abdomen | Crohns disease
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