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PLoS Pathogens, ISSN 1553-7366, 12/2014, Volume 10, Issue 12
  Macrophage activation of NAD(P)H oxidase (NOX2) and reactive oxygen species (ROS) is suggested to kill Trypanosoma cruzi that causes Chagas disease. However,... 
Protozoa | Parasites | Rodents | Immune system
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e28449 - e28449
Trypanosoma cruzi elicits reactive oxygen species (ROS) of inflammatory and mitochondrial origin in infected hosts. In this study, we examined ROS-induced... 
CELLS | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | CARDIOMYOPATHY | MITOCHONDRIAL DYSFUNCTION | MICE | CANDIDATES | PROTEINS | EXPRESSION | TRYPANOSOMA-CRUZI INFECTION | TERT-BUTYL-NITRONE | Chagas Disease - etiology | Chagas Cardiomyopathy - immunology | Chagas Disease - parasitology | Chagas Disease - immunology | Myocardium - immunology | Reactive Oxygen Species - metabolism | Myocytes, Cardiac - immunology | Humans | Chagas Cardiomyopathy - metabolism | Chagas Disease - metabolism | Reactive Oxygen Species - immunology | Myocardium - metabolism | Heart - parasitology | Trypanosoma cruzi - immunology | Oxidation-Reduction | Rats | Antibody Affinity | Antigens - metabolism | Clinical Trials as Topic | Myocytes, Cardiac - parasitology | Rats, Sprague-Dawley | Mice, Inbred C3H | Chagas Cardiomyopathy - etiology | Autoantibodies - immunology | Chagas Cardiomyopathy - pathology | Animals | Myocytes, Cardiac - metabolism | Protein Binding | Antigens - immunology | Mice | Proteins | Viral antibodies | Antigens | Antibodies | Chagas' disease | Comparative analysis | Cardiology | Enzyme-linked immunosorbent assay | Heart | Reactive oxygen species | Hydrogen peroxide | Connectin | Target recognition | 4-Hydroxynonenal | Change detection | Pathogenesis | Bipolar disorder | Parasites | Western blotting | Tropical diseases | Antioxidants | Mitochondria | Rodents | Oxidation | Heart diseases | Recombinant | Adducts | Carbonyls | Vector-borne diseases | Immune response | Preservation | Gel electrophoresis | Contractility | Cardiomyocytes | Inflammation | Patients | Muscle contraction | Coronary artery disease | Malondialdehyde | Immune systems | Immunogenicity | Determinants | Antigenic determinants | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, pp. e0158895 - e0158895
Journal Article
Metabolic Brain Disease, ISSN 0885-7490, 12/2017, Volume 32, Issue 6, pp. 2045 - 2061
Amyloid beta (Aβ) peptide deposition is the primary cause of neurodegeneration in Alzheimer’s disease (AD) pathogenesis. Several reports point towards the role... 
Biochemistry, general | Chlorpyrifos | Neurosciences | Alzheimer’s disease | Amyloid beta protein | APE1 | Metabolic Diseases | Oncology | Monocrotophos | Neurology | Biomedicine | Nrf2 | Curcumin | APURINIC/APYRIMIDINIC ENDONUCLEASE-1 | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | TRANSGENIC MOUSE | MITOCHONDRIA-MEDIATED APOPTOSIS | NEUROBLASTOMA-CELLS | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | IN-VITRO | BASE EXCISION-REPAIR | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | Alzheimer's disease | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Curcumin - pharmacology | Peptide Fragments - pharmacology | Monocrotophos - pharmacology | Organophosphates - pharmacology | Up-Regulation - drug effects | Neuroprotective Agents - pharmacology | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Chlorpyrifos - pharmacology | Neurons - metabolism | Oxidative Stress - drug effects | Neurons - drug effects | Enzymes | Enzyme inhibitors | Nitric oxide | Pesticides | Oxidative stress | DNA polymerase | Pathogenesis | DNA damage | Confocal | DNA repair | Base excision repair | Antioxidants | Proteins | Neurotoxicity | Agrochemicals | Neurodegeneration | Organophosphorus pesticides | Pretreatment | Repair | Deoxyribonucleic acid--DNA | Stresses | Cell survival | Neurodegenerative diseases | Gene expression | Survival | Nitric-oxide synthase | Stress | Polymerase | Poly(ADP-ribose) Polymerase 1 | Cell lines | β-Amyloid | DNA-directed DNA polymerase | Index Medicus
Journal Article
Journal Article
Metabolic Brain Disease, ISSN 0885-7490, 8/2018, Volume 33, Issue 4, pp. 1307 - 1326
Maintaining genomic integrity is essential for cell survival and viability. Reactive oxygen species (ROS) overproduction results in oxidative stress leading to... 
Biochemistry, general | Neurology | Neurosciences | Biomedicine | GBM | APE1 | PKM2 | Metabolic Diseases | ROS | ENPP2 | Oncology | APE1/REF-1 | PROTEIN | CANCER CELLS | LYSOPHOSPHATIDIC ACID LPA | NEUROSCIENCES | LYSOPHOSPHOLIPASE-D | PYRUVATE-KINASE | DNA | GROWTH | ENDOCRINOLOGY & METABOLISM | AUTOTAXIN | APURINIC/APYRIMIDINIC ENDONUCLEASE ACTIVITY | Phosphoric Diester Hydrolases - metabolism | Humans | Oxidative Stress - physiology | Rats | Animals | Carrier Proteins - metabolism | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | Neoplasm Invasiveness - pathology | Thyroid Hormones - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Signal Transduction - physiology | Membrane Proteins - metabolism | Oxidases | Oxidative stress | Research | Glioblastoma multiforme | Oncology, Experimental | Cancer | Cell proliferation | Glucose oxidase | Hydrogen peroxide | Downstream effects | Crosstalk | Oxidizing agents | Glioblastoma | Cytotoxicity | Base excision repair | Western blotting | Genomic instability | Metastases | Proteins | Oxidants | Conditioning | Lesions | Localization | Deoxyribonucleic acid--DNA | Stresses | Enzymes | Stability | Cell survival | Pyruvate kinase | Secretion | Therapeutic applications | Invasiveness | Poly(ADP-ribose) polymerase | Gene expression | Survival | Lysophosphatidic acid | Glycolysis | Glioblastoma cells | Endonuclease | Immunofluorescence | Viability | Cell migration | Index Medicus
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 06/2015, Volume 93, Issue 6, p. 938
  Accumulating evidence points to roles for oxidative stress, amyloid beta (A[beta]), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease... 
Nucleases | Neuroblastoma
Journal Article
PLoS Pathogens, 12/2014, Volume 10, Issue 12
  Macrophage activation of NAD(P)H oxidase (NOX2) and reactive oxygen species (ROS) is suggested to kill Trypanosoma cruzi that causes Chagas disease. However,... 
Protozoa | Rodents | Parasites | Immune system
Journal Article