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Molecular medicine (Cambridge, Mass.), ISSN 1076-1551, 05/2003, Volume 9, Issue 5-8, pp. 154 - 165
Journal Article
Molecular Medicine, ISSN 1076-1551, 05/2003, Volume 9, Issue 5-8, pp. 154 - 165
To assess whether retinoblastoma formation is associated with the expression of high mobility group (HMG) A2 protein, a transcription factor that is highly... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURAL TRANSCRIPTION FACTOR | I-C PROTEIN | MESENCHYMAL TUMORS | NEOPLASTIC TRANSFORMATION | CELL BIOLOGY | THYROID-CELLS | GENOMIC STRUCTURE | DNA | SEQUENCE | MOBILITY GROUP PROTEIN | CDNA CLONING
Journal Article
Investigative Ophthalmology & Visual Science, ISSN 0146-0404, 02/2004, Volume 45, Issue 2, pp. 375 - 384
The Chx10 homeobox gene is expressed in neural progenitor cells during retinal development. The absence of Chx10 causes microphthalmia in humans and in the... 
Homeodomain Proteins - metabolism | Repressor Proteins | Transcription Factors - deficiency | Retina - embryology | RNA, Messenger - metabolism | Rhodopsin - metabolism | DNA-Binding Proteins - metabolism | In Situ Hybridization | Mice, Mutant Strains | Rod Opsins - metabolism | Trans-Activators - genetics | Transcription Factor Brn-3B | Membrane Glycoproteins | Arrestin - metabolism | Fluorescent Antibody Technique, Indirect | Gene Expression Regulation, Developmental - physiology | Peripherins | Transcription Factors - physiology | Paired Box Transcription Factors | Mice, Inbred C57BL | PAX6 Transcription Factor | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Animals | Transcription Factor Brn-3 | Trans-Activators - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 | Mice | Photoreceptor Cells, Vertebrate - metabolism | Homeodomain Proteins - physiology | Eye Proteins | Intermediate Filament Proteins - metabolism | Photoreceptor Cells, Vertebrate - pathology | Retina - pathology | ROD PHOTORECEPTORS | OCULAR RETARDATION | RDS MUTANT MICE | GANGLION-CELLS | PROGENITOR PROLIFERATION | OPHTHALMOLOGY | MOUSE RETINA | HOMEOBOX GENE | TRANSCRIPTION FACTOR | CELL-FATE DETERMINATION | HOMEODOMAIN PROTEIN
Journal Article
Investigative Opthalmology & Visual Science, ISSN 1552-5783, 02/2004, Volume 45, Issue 2, p. 375
Journal Article
2005
ChxlO is a homeobox transcription factor essential for the development of the vertebrate eye. A mutation in the human gene CHX10 causes microphthalmia and a... 
Dissertation
Investigative Opthalmology & Visual Science, ISSN 1552-5783, 01/2006, Volume 47, Issue 1, p. 386
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 2006, Volume 17, Issue 1, pp. 31 - 39
Journal Article
Hematology/Oncology Clinics of North America, ISSN 0889-8588, 06/2009, Volume 23, Issue 3, pp. 529 - 545
The RAS/RAF/MEK/ERK signaling pathway has emerged as a major player in the induction and maintenance of melanoma, particularly the protein kinase BRAF, mutated... 
Targeted therapies | BRAF | Small molecule inhibitors | Melanoma | MAPK signaling | ORAL MEK INHIBITOR | ACQUIRED-RESISTANCE | PHASE-II | MALIGNANT-MELANOMA | ONCOGENE-INDUCED SENESCENCE | REGULATED KINASE KINASE | HOMOLOG B1 BRAF | CELLULAR SENESCENCE | CANCER-THERAPY | ONCOLOGY | AZD6244 ARRY-142886 | HEMATOLOGY | Niacinamide - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - genetics | Drugs, Investigational - pharmacology | Proto-Oncogene Proteins B-raf - physiology | Humans | Neoplasm Proteins - physiology | Drugs, Investigational - therapeutic use | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Melanoma - enzymology | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Benzenesulfonates - therapeutic use | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Extracellular Signal-Regulated MAP Kinases - genetics | Drug Delivery Systems | Benzenesulfonates - pharmacology | Melanoma - genetics | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Pyridines - therapeutic use | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Clinical Trials as Topic | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Mutation | Genes, ras
Journal Article
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 02/2010, Volume 23, Issue 1, pp. 112 - 120
Summary We recently demonstrated that expression of V600EBraf in mature mouse melanocytes induces melanoma. Here, we show that expression of V600EBraf using... 
inducible expression | tyrosi‐nase promoter | V600EBraf | Cre recombinase | melanoblasts | Inducible expression | Tyrosi-nase promoter | Braf | Melanoblasts | Genetic research | Developmental genetics | Research | Oncology, Experimental | Cancer
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 3, pp. 207 - 215
Journal Article
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